Milwaukee Brewers vs. St. Louis Cardinals Picks and Prediction for Saturday, September 20, 2025
In the middle game of a three-game National League Central series, the Milwaukee Brewers are taking on the St. Louis Cardinals inside Busch Stadium on Saturday evening in our Brewers vs. Cardinals prediction. This article is being written before Friday’s game. The Brewers are first in the NL Central with a 94-59 record and are sending rookie right-hander Chad Patrick to the mound. The Cardinals are fourth in the NL Central with a 74-79 record and have veteran righty Miles Mikolas getting the ball. Dial in your read with MLB picks for the Milwaukee Brewers vs. the St. Louis Cardinals before first pitch.
Brewers Looking to Lock Top Seed
The Milwaukee Brewers are looking to build momentum towards the playoffs after their 5-2 home win over the Los Angeles Angels on Thursday. The lineup was able to go 9-for-31 with five walks and a pair of strikeouts on the day. The Brewers went 4-for-9 with runners in scoring position and stranded eight men on base. Quinn Priester continues to pitch well as he did not factor into the decision, but threw 5.2 innings and allowed two runs.
The Brewers are sending rookie right-hander Chad Patrick to pitch and he is stepping up as in 24 games (21 starts), he is 3-8 in 111.1 innings with a 3.64 ERA and a 1.28 WHIP. He has been excellent in terms of his command as he has 37 walks to 116 strikeouts. Patrick faced the Cardinals twice this season (one start) and is 0-1 in 5.1 innings and gave up two runs on five hits with two walks and three strikeouts.
Injury Report for Milwaukee
- Pitcher Jose Quintana: Calf (OUT)
- Pitcher Shelby Miller: Elbow (OUT)
- Pitcher Trevor Megill: Flexor Strain (OUT)
- Pitcher Logan Henderson: Elbow (OUT)
- Pitcher DL Hall: Oblique (OUT)
- Pitcher Jordan Montgomery: Elbow (OUT)
- Center fielder Garrett Mitchell: Oblique (OUT)
- Pitcher Connor Thomas: Elbow (OUT)
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Cardinals Looking to Get to .500
The St. Louis Cardinals are looking to finish the season well after Wednesday’s 6-2 home loss against the Cincinnati Reds in their most recent game. The Cards were able to go 5-for-31 with four walks and 11 strikeouts at the plate as Alec Burleson hit a home run while Victor Scott II stole a base. St. Louis finished 0-for-8 with runners in scoring position while leaving six men on base. Andre Pallante struggled in the loss as he gave up four runs in five innings of work.
Veteran right-hander Miles Mikolas is going to be taking the mound for the St. Louis Cardinals in this game and has struggled as he is 8-10 with a 4.80 ERA and a 1.31 WHIP in 146.1 innings over 29 starts. He has not done too well in limiting homers, as he has given up 26 so far after 26 in 171.2 innings last season. Mikolas faced the Brew Crew twice this season and is 1-1 in 11.0 innings and allowed four runs on 11 hits with one walk and 12 strikeouts.
Injury Report for St. Louis
- First baseman Willson Contreras: Shoulder (OUT)
- Shortstop Masyn Winn: Meniscus (OUT)
- Pitcher Zack Thompson: Lat (OUT)
Milwaukee Brewers vs. St. Louis Cardinals Pick
Spread Pick for Brewers vs. Cardinals
- Milwaukee Brewers ML (5 units)
Looking at the last 15 games for these pitchers, there is a significant difference as Chad Patrick is 1-5 with a 3.91 ERA and a 1.30 WHIP in 69.0 innings (13 starts) while Miles Mikolas is 4-6 with a 5.23 ERA and a 1.32 WHIP in 74.0 innings (15 starts) in that span. The road/home splits for these offenses are on completely different levels, as the Brewers are averaging 5.49 runs in their 75 road games, while the Cardinals are scoring 4.26 runs in their 78 home games thus far. The Brew Crew is 6-2 in their previous eight games against the Cardinals so take them to win once again here.
Over/Under Pick for Brewers vs. Cardinals
- Over (4 units)
Since the All-Star break, these pitchers are struggling a bit as Chad Patrick is 0-1 with a 4.32 ERA and a 1.20 WHIP in 16.2 innings (five games, three starts) while Miles Mikolas is 3-4 with a 4.56 ERA and a .277 batting average against in 53.1 innings (11 starts) up to this point. In the previous seven days, these teams have been hitting well as Milwaukee is eighth with a .790 team OPS, while St. Louis is 16th with a .740 team OPS right now. All in all, go with the over as the best bet.
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