Milwaukee Brewers vs. St. Louis Cardinals Picks and Prediction for Sunday, September 21, 2025
In the final game of a three-game National League Central series, the Milwaukee Brewers are taking on the St. Louis Cardinals at Busch Stadium on Sunday afternoon in our Brewers vs. Cardinals prediction. This article is being written ahead of Saturday’s game. The Brewers are first in the NL Central with a 94-60 record and are sending right-hander Erick Fedde to the mound. The Cardinals are fourth in the NL Central with a 75-79 record and have young southpaw Matthew Liberatore getting the ball. From splits to bullpens, MLB predictions for Milwaukee Brewers vs. St. Louis Cardinals highlight the edge.
Brewers Looking to Get Closer to Clinching Top Seed
The Milwaukee Brewers are looking to bounce back after their 7-1 road loss against the St. Louis Cardinals to start the series on Friday. The lineup was able to go 12-for-39 with one walk and 11 strikeouts on the day as Sal Frelick’s home run was the team’s offense. Milwaukee went 0-for-8 with runners in scoring position and stranded 12 men on base. Jacob Misiorowski struggled in the loss as he pitched 3.2 innings and gave up two runs.
The Brew Crew are sending right-hander Erick Fedde to pitch and he is not doing well as in 30 games (24 starts), he is 4-13 in 134.1 innings with a 5.49 ERA and a 1.56 WHIP. He has been getting hit way too much as he has a .277 batting average against, which is the his worst since 2018. He faced his former teammates from earlier in the season once out of the bullpen as he pitched 1.1 no-hit innings and allowed two walks and zero strikeouts without factoring into the decision.
Injury Report for Milwaukee
- Pitcher Jose Quintana: Calf (OUT)
- Pitcher Shelby Miller: Elbow (OUT)
- Pitcher Trevor Megill: Flexor Strain (OUT)
- Pitcher Logan Henderson: Elbow (OUT)
- Pitcher DL Hall: Oblique (OUT)
- Pitcher Jordan Montgomery: Elbow (OUT)
- Center fielder Garrett Mitchell: Oblique (OUT)
- Pitcher Connor Thomas: Elbow (OUT)
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The St. Louis Cardinals are looking to build off Friday’s 7-1 home win over the Milwaukee Brewers in their most recent game. The Cards were able to go 14-for-34 with four walks and six strikeouts at the plate as the team hit four doubles. St. Louis finished 6-for-18 with runners in scoring position while leaving nine men on base. Sonny Gray looked sharp in the win as he pitched six innings and allowed one run.
Young southpaw Matthew Liberatore is going to be toeing the slab for the St. Louis Cardinals in this game and has been holding his own as he is 7-12 with a 4.40 ERA and a 1.31 WHIP in 146.2 innings over 28 starts. He has not been a pitcher who has relied on strikeouts, as he has 116 strikeouts in 146.2 innings, significantly less than one per inning. Liberatore faced the Brewers once earlier this season
Injury Report for St. Louis
- First baseman Willson Contreras: Shoulder (OUT)
- Shortstop Masyn Winn: Meniscus (OUT)
- Pitcher Zack Thompson: Lat (OUT)
Milwaukee Brewers vs. St. Louis Cardinals Pick
Spread Pick for Brewers vs. Cardinals
- Milwaukee Brewers ML (5 units)
In September, these pitchers are showing a bit of a divide as Erick Fedde is 0-0 with a 0.00 ERA and a .059 batting average against in 5.0 innings (four relief appearances) while Matthew Liberatore is 1-1 with a 4.11 ERA and a 1.24 WHIP in 15.1 innings (three starts) this month. Hitting with runners in scoring position shows a wide difference with these offenses, as the Brewers are tied with the New York Yankees and Tampa Bay Rays for eighth place with a .774 team OPS in those at-bats, while the Cardinals are 24th with a .710 team OPS with runners in scoring position. Milwaukee is 6-3 against St. Louis in their last nine games against one another so take the Milwaukee Brewers to win once again here.
Over/Under Pick for Brewers vs. Cardinals
- Over (5 units)
Since the All-Star break, these pitchers are struggling to put zeroes on the board consistently as Erick Fedde is 1-4 with a 7.32 ERA and a .313 opposing batting average in 35.2 innings (11 games, five starts) while Matthew Liberatore is 1-5 with a 4.66 ERA and a 1.45 WHIP in 46.1 innings (10 starts) since the break. In the last five games, these teams are scoring well as the Brewers are averaging 5.2 runs per game while the Cardinals are scoring 4.2 runs per game in that stretch. All in all, go with the over to hit in this game.
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