Minnesota Twins vs Houston Astros Picks and Prediction for Monday June 29 2026

By: Kim Smith Published 06/29/2026, 12:40 AM ET
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The Minnesota Twins travel to Daikin Park in Houston, Texas, to take on the Houston Astros on Monday, June 29, 2026. First pitch is scheduled for 8:10 PM ET, and the game will be televised on MLB.TV. At the time of this writing the odds were not released. Be sure to check out our free MLB picks before placing any wagers.

Starting Pitchers Get the Call

Zebby Matthews is expected to start for Minnesota. He enters the game with a 3-5 record, a 4.56 ERA, a 1.20 WHIP, 49.1 innings pitched, 48 hits allowed, 39 strikeouts, 11 walks, and 10 home runs allowed. Houston will counter with Peter Lambert, who carries a 6-4 record, a 3.28 ERA, a 1.17 WHIP, 68.2 innings pitched, 52 hits allowed, 64 strikeouts, 28 walks, and 7 home runs allowed. Based strictly on the provided numbers, Lambert holds the edge in wins, ERA, WHIP, innings pitched, and home runs allowed, while Matthews has issued fewer walks.

Minnesota Hopes to Regain Its Footing

The Twins enter this matchup with a 39-45 overall record and an 18-22 road record. Minnesota recently lost to Colorado, previously defeated Colorado in extra innings, and before that dropped three consecutive games to Los Angeles. The Twins have gone 1-4 over their last five games and will be looking to build on their most recent home series before heading into this contest.

Minnesota is batting .247 with 409 runs, 703 hits, 102 home runs, a .322 on-base percentage, and a .411 slugging percentage. The pitching staff has compiled a 4.89 ERA, a 1.41 WHIP, 308 walks, 678 strikeouts, and a .257 opponent batting average. The Twins are 16-21 in day games.

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The strength of Minnesota’s club has been its offense. The Twins own advantages over Houston in batting average, runs scored, hits, on-base percentage, and slugging percentage. Their 102 home runs also demonstrate solid power throughout the lineup based on the season totals provided.

Houston Returns Home After a Strong Road Trip

The Astros come into Monday night with a 41-44 overall record and a 20-21 home record. Houston recently defeated Detroit twice while dropping another game in that series, and before that earned two victories over Toronto. The Astros have won four of their last five games, giving them momentum entering this home matchup.

Houston is batting .243 with 380 runs, 694 hits, 109 home runs, a .316 on-base percentage, and a .409 slugging percentage. The Astros have produced a 4.77 ERA and a 1.39 WHIP while limiting opponents to a .242 batting average. They have also recorded 367 walks and 732 strikeouts. Houston owns a 17-16 record in day games.

Houston’s biggest advantage is its power and strikeout production. The Astros have hit 109 home runs, which is more than Minnesota, and they have also recorded 732 strikeouts while allowing opponents to hit just .242, giving them a slight edge on the pitching side.

Minnesota Twins vs Houston Astros Picks and Prediction

Minnesota Twins vs Houston Astros Pick

Pick: Houston Astros Moneyline

Houston gets my pick in this matchup. The Astros have won four of their last five games and send Peter Lambert to the mound with the stronger statistical profile. While Minnesota has produced better overall offensive numbers throughout the season, Houston owns the edge in home runs, strikeouts, opponent batting average, and the starting-pitching matchup. Those advantages make the Astros my choice at home.

Minnesota Twins vs Houston Astros Total Pick

Pick: Over 8.5

I would take the over if the total is set at 8.5. Minnesota has scored 409 runs and Houston has produced 380 while both clubs have surpassed 100 home runs. Neither team owns a staff ERA below 4.75, and both offenses have shown enough season-long production to make this look like a matchup capable of generating several runs.

Final Score Prediction: Houston Astros 6 – Minnesota Twins 4

This prediction was written before the completion of game play on Sunday.

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