Minnesota Twins vs. Philadelphia Phillies Picks and Prediction for Saturday, September 27, 2025

By: Patty Reyes Published 09/27/2025, 03:17 AM ET
Minnesota Twins vs. Philadelphia Phillies Picks and Prediction for Saturday, September 27, 2025
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The Minnesota Twins (69-91, 73-80-7 O/U) will be taking on the Philadelphia Phillies (95-65, 71-79-10 O/U) on Saturday evening in the middle game of a three-game interleague series for our Twins vs. Phillies prediction. The Phillies won the opening game on Friday, 3-1. Rookie right-hander Mick Abel (2-4, 7.36 ERA) is going to be pitching in this game for the Twins while the Phillies are sending southpaw Ranger Suarez (12-7, 3.12 ERA) to the hill. Today’s edge: MLB predictions for Minnesota Twins vs. Philadelphia Phillies built on form and matchups.

Twins Looking Towards 2026

The Minnesota Twins are looking to continue figuring out things for the future as they are in the fourth spot in the American League Central, as they have a 69-90 record up to this point. The offense is doing a respectable job as they are tied with the San Diego Padres for 17th in baseball with a .239/.311/.397 team slash line while averaging 4.2 runs per game.

The Minnesota Twins are coming off Friday’s 3-1 road loss against the Philadelphia Phillies and it doesn’t help going 0-for-4 with runners in scoring position. Joe Ryan pitched well in the loss as he gave up two runs in five innings.

Designated hitter Trevor Larnach (17 HR, .722 OPS) has been hitting at a good level and continuing to impress in a lost season. Rookie right-hander Mick Abel (2-4, 7.36 ERA) is going to be on the mound and is coming off a no-decision against the Cleveland Guardians, where he allowed two runs on one hit with three walks and six strikeouts in four innings out of the bullpen.

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Injury Report for Minnesota

  • Second baseman Luke Keaschall: Thumb (OUT)
  • Pitcher Pablo Lopez: Forearm (OUT)
  • Right fielder Matt Wallner: Oblique (OUT)
  • Pitcher Justin Topa: Oblique (OUT)
  • Left fielder Alan Roden: Thumb (OUT)
  • Pitcher Anthony Misiewicz: Shoulder (OUT)
  • Pitcher David Festa: Shoulder (OUT)

Phillies Looking to Enter Postseason Hot

The Philadelphia Phillies are looking to enter the postseason on a hot stretch as they are first in the NL East with a 94-65 record up to this point. The Phillies are hitting at an incredible level as they are third in MLB with a .763 team OPS while averaging 4.85 runs per game.

The Philadelphia Phillies are coming off a 3-1 home win over the Minnesota Twins on Friday and it helps having Edmundo Sosa hit a home run. Aaron Nola dominated on the mound as he had allowed one run in eight innings of work in a win.

First baseman Bryce Harper (27 HR, .850 OPS) has been a significant threat at the plate and should be able to end the season on the right foot. Left-hander Ranger Suarez (12-7, 3.12 ERA) will be taking the mound and is coming off a loss against the Arizona Diamondbacks, where he threw 4.0 innings and gave up six runs on eight hits with one walk and a pair of strikeouts.

Injury Report for Philadelphia

  • Left fielder Max Kepler: Illness (Questionable)
  • Pitcher Jose Alvarado: Forearm (OUT)
  • Shortstop Trea Turner: Hamstring (OUT)
  • Pitcher Daniel Robert: Forearm (OUT)
  • Pitcher Zack Wheeler: Blood Clot (OUT)
  • Pitcher Jordan Romano: Finger (OUT)

Minnesota Twins vs. Philadelphia Phillies Pick

Spread Pick for Twins vs. Phillies

  • Philadelphia Phillies ML (4 units)

The Philadelphia Phillies are clearly the better team and should remain hot as the regular season winds down against one of the worst teams since the All-Star break. These pitchers lately are showing a major difference as Mick Abel is 1-2 with a 9.31 ERA and a 1.76 WHIP in 9.2 innings (three starts), while Ranger Suarez is 2-1 with a 3.68 ERA and a .268 batting average against in 22.0 innings (four starts) lately. All in all, go with the Philadelphia Phillies to secure the win here.

Over/Under Pick for Twins vs. Phillies

  • Over (4 units)

These bullpens have been unable to get much of anything going throughout the season, as the Twins are 26th in baseball with a 4.63 reliever ERA, while the Phillies are not too much better at 20th place with a 4.29 bullpen ERA so far. During September, these lineups have been producing at a great level as Minnesota is tied with the Washington Nationals for 16th with a .705 team OPS while Philadelphia is best in the majors with a .844 team OPS. Take the over as it hit in two of their previous three games so we will be taking the over to hit in this game as well.

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