New York Mets vs. Chicago Cubs Picks and Prediction for Wednesday, September 24, 2025
In the middle game of a three-game National League series, the New York Mets are facing off against the Chicago Cubs inside Wrigley Field on Wednesday night in our Mets vs. Cubs prediction. This article is being written before Tuesday’s game. The Mets are second in the NL East with an 80-76 record and are sending rookie right-hander Jonah Tong to the mound. The Cubs are second in the NL Central with an 88-68 record and have veteran left-hander Matthew Boyd getting the ball. From splits to bullpens, MLB predictions for the New York Mets vs. Chicago Cubs highlight the edge.
Mets Spiraling Out of Playoff Picture
The New York Mets are looking to recover after Sunday’s 3-2 home loss against the Washington Nationals in their most recent game. The Mets were able to go 8-for-33 with two walks and seven strikeouts at the plate as Francisco Lindor hit a home run. New York finished 1-for-5 with runners in scoring position while leaving six men on base. Sean Manaea lost the start as he allowed three runs in three innings of work.
Rookie right-hander Jonah Tong is going to be taking the mound for the New York Mets in this game and has been struggling as he is 2-2 with a 5.94 ERA and a 1.44 WHIP in 16.2 innings over four starts. He has been struggling in terms of limiting the amount of hits, as he has allowed a .262 batting average against this year. Tong is facing the Cubs for the first time in his young career, so this will be a good test for him.
Injury Report for New York
- Pitcher Reed Garrett: Elbow (OUT)
- Left fielder Jesse Winker: Back (OUT)
- Center fielder Tyrone Taylor: Hamstring (OUT)
- Pitcher Frankie Montas Jr: Elbow (OUT)
- Pitcher Max Kranick: Elbow (OUT)
- Pitcher Dedniel Nunez: Elbow (OUT)
- Pitcher Tylor Megill: Elbow (OUT)
- Pitcher Griffin Canning: Achilles (OUT)
- Pitcher Danny Young: Elbow (OUT)
- Pitcher AJ Minter: Lat (OUT)
- Pitcher Christian Scott: Elbow (OUT)
- Third baseman Nick Madrigal: Shoulder (OUT)
- Pitcher Drew Smith: Elbow (OUT)
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Cubs Looking to Capture Top NL Wild Card Spot
The Chicago Cubs are looking to shake off their 1-0 road loss against the Cincinnati Reds on Sunday. The lineup was able to go 6-for-33 with three walks and six strikeouts on the day as Dansby Swanson stole a base. The Cubs went 0-for-7 with runners in scoring position and stranded nine men on base. Jameson Taillon recorded the loss despite pitching well, as he gave up one run in seven innings.
The Cubs are sending veteran southpaw Matthew Boyd to pitch, and he is stepping up as in 30 starts, he is 13-8 in 174.1 innings with a 3.20 ERA and a 1.11 WHIP. He has shown a great ability to control his pitches as he has 41 walks to 151 strikeouts. Boyd faced the Mets once earlier this season and did not factor into the decision as he pitched six innings and gave up two runs on six hits with two hit by pitches, zero walks, and eight strikeouts.
Injury Report for Chicago
- Right fielder Owen Caissie: Concussion (OUT)
- Right fielder Kyle Tucker: Calf (OUT)
- Pitcher Daniel Palencia: Shoulder (OUT)
- Pitcher Ryan Braiser: Groin (OUT)
- Catcher Miguel Amaya: Ankle (OUT)
- Pitcher Justin Steele: Elbow (OUT)
New York Mets vs. Chicago Cubs Pick
Spread Pick for Mets vs. Cubs
- Chicago Cubs ML (5 units)
Jonah Tong has struggled throughout his limited action while Matthew Boyd is stepping up and dominating overall. In the previous 30 days, the Mets are 24th in the bigs with a 4.90 team ERA while the Cubs are 15th with a 4.08 team ERA in that span. These bullpens are pitching with a bit of a divide as New York is 14th with a 3.98 reliever ERA while Chicago is 12th with a 3.80 bullpen ERA this season. Go with the Chicago Cubs to win this game at home.
Over/Under Pick for Mets vs. Cubs
- Over (5 units)
In September, these pitchers are struggling as Jonah Tong is 1-2 with a 7.71 ERA and a 1.54 WHIP in 11.2 innings (three starts) while Matthew Boyd is 1-1 with a 6.00 ERA and a .317 batting average against in 15.0 innings (three starts) so far. Both teams are dominating with runners in scoring position at the plate as the Mets are third with a .801 team OPS with runners in scoring position, while the Cubs are eighth with a .773 team OPS in those at-bats. All in all, go with the over as the better bet.
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