New York Mets vs Philadelphia Phillies Picks and Prediction for Wednesday, September 10, 2025
Our Mets vs. Phillies prediction sees the New York Mets (76-68) getting ready to take on the Philadelphia Phillies (84-60) in National League East action at Citizens Bank Park on Wednesday evening in the third game of a four-game series. This article is being written ahead of Tuesday’s game. Right-hander Clay Holmes gets the start for the Mets while southpaw Cristopher Sanchez pitches for the Phillies. From splits to bullpens, MLB predictions for the New York Mets vs the Philadelphia Phillies that cut through the noise.
Mets Looking to Hold Onto NL East Hope
The New York Mets are coming off a 1-0 road loss on Monday against the Philadelphia Phillies last time out. The team struggled offensively as they were able to go 5-for-31 with three walks and 11 strikeouts as on the day. The Mets were hitless in four at-bats with runners in scoring position and left seven men on base. Nolan McLean pitched well in a losing effort as he allowed one run in 5.1 innings of work.
The Mets are going to be sending right-hander Clay Holmes to the mound and he is currently 11-7 with a 3.61 ERA and a 1.33 WHIP in 147.0 innings. He has done well throughout the season in terms of limiting hits as he has a .246 opposing batting average right now. Holmes faced the Phillies twice last season as a member of the New York Yankees as he went 0-0 in 2.0 innings and allowed one run on four hits with one intentional walk and zero strikeouts with a save.
Injury Report for New York
- Center fielder Tyrone Taylor: Hamstring (OUT)
- Pitcher Frankie Montas: Elbow (OUT)
- Left fielder Jesse Winker: Back (OUT)
- Pitcher Max Kranick: Elbow (OUT)
- Pitcher Dedniel Nunez: Elbow (OUT)
- Pitcher Tylor Megill: Elbow (OUT)
- Pitcher Griffin Canning: Achilles (OUT)
- Center fielder Jose Siri: Shin (OUT)
- Pitcher Danny Young: Elbow (OUT)
- Pitcher AJ Minter: Lat (OUT)
- Pitcher Christian Scott: Elbow (OUT)
- Third baseman Nick Madrigal: Shoulder (OUT)
- Pitcher Drew Smith: Elbow (OUT)
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Phillies Looking to Get Closer to Clinching NL East
The Philadelphia Phillies are looking to continue stepping up after their 1-0 home win on Monday against the New York Mets to begin their series. The lineup was able to go 7-for-29 with three walks and eight strikeouts in the game. The team was 1-for-4 with runners in scoring position and stranded seven on base. Aaron Nola pitched well in the win as he pitched six shutout innings of work.
Left-hander Cristopher Sanchez will be getting the start for the Philadelphia Phillies and is stepping up as he is 12-5 with a 2.60 ERA and a 1.12 WHIP in 176.1 innings (28 starts) so far. He has been able to pitch with outstanding command as he has 42 walks to 186 strikeouts up to this point. Sachez is facing the Mets for a third time this season as he is 0-2 in 7.1 innings and allowed eight runs on 12 hits with five walks and six strikeouts.
Injury Report for Philadelphia
- Shortstop Trea Turner: Hamstring (Questionable)
- Pitcher Daniel Robert: Forearm (OUT)
- Pitcher Zack Wheeler: Blood Clot (OUT)
- Pitcher Jordan Romano: Finger (OUT)
New York Mets vs. Philadelphia Phillies Pick
Spread Pick for New York Mets vs. Philadelphia Phillies
- Philadelphia Phillies ML (5 units)
When looking at the previous seven starts for these pitchers, there is a gap. Clay Holmes is 2-2 with a 4.32 ERA and a 1.50 WHIP in 33.1 innings while Cristopher Sanchez is 3-2 with a 2.76 ERA and a 1.18 WHIP in 45.2 innings in that stretch. These offenses over the last week show a bit of a divide as well. New York is averaging 2.4 runs in their last five games, while Philadelphia is scoring 3.83 runs in their previous six games played. All in all, go with the Philadelphia Phillies to secure the win in this game.
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Over/Under Pick for New York Mets vs. Philadelphia Phillies
- Over (4 units)
These teams have been two of the best offensive teams since the All-Star break as New York is third in the majors with a .799 team OPS, while Philadelphia is fifth with a .793 team OPS right now. Both bullpens are giving up runs at a middling level as the Mets are 13th in MLB with a 3.96 bullpen ERA, while the Phillies are 21st with a 4.28 reliever ERA entering this game. Go with the over as the better bet as these teams should score well here.
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