New York Yankees vs. Minnesota Twins Picks and Prediction for Wednesday, September 17, 2025

By: Robert Antuann Published 09/17/2025, 05:22 AM ET
New York Yankees at Minnesota Twins Picks
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Our Yankees vs. Twins prediction sees the New York Yankees (83-67) getting ready to take on the Minnesota Twins (66-84) in American League action at Target Field on Wednesday evening in the final game of a three-game series. This article is being written ahead of Tuesday’s game. Right-hander Luis Gil gets the start for the Yankees while young righty Tah Bradley pitches for the Twins. From splits to bullpens, MLB predictions for New York Yankees at Minnesota Twins highlight the edge.

Yankees Looking to Keep Top AL Wild Card Spot

The New York Yankees are looking to recover from their 7-0 road loss on Monday against the Minnesota Twins to begin their series. The lineup was able to go just 2-for-28 with five walks and 14 strikeouts as Ryan McMahon stole a base. The Yankees were 0-for-3 with runners in scoring position and stranded six men on base. Carlos Rodon pitched well in a losing effort as he allowed a pair of runs in six innings.

Young right-hander Luis Gil is getting the start for the New York Yankees and has only made eight starts this season. He is 4-1 with a 2.83 ERA and a 1.40 WHIP in 41.1 innings of work. He has been struggling with his command as he has 27 walks to 34 strikeouts entering this start. Gil faced the Twins once last season in a victory as he pitched six shutout innings and gave up one hit with three walks and six strikeouts.

Injury Report for New York

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  • Pitcher Brent Headrick: Forearm (OUT)
  • Pitcher Jonathan Loaisiga: Back (OUT)
  • Pitcher Clarke Schmidt: Forearm (OUT)
  • Third baseman Oswaldo Cabrera: Ankle (OUT)
  • Pitcher Jake Cousins: Elbow (OUT)
  • Pitcher Gerrit Cole: Elbow (OUT)

Twins Looking to Play Spoiler

The Minnesota Twins are coming off a 7-0 home win on Monday over the New York Yankees last time out. The team stepped up offensively as they were able to go 9-for-30 with three walks and five strikeouts as a whole with Brooks Lee hitting a homer while Austin Martin (x2) and Matt Wallner each stole a base. Minnesota was 4-for-9 with runners in scoring position and left three men on base. Simeon Woods Richardson pitched well in the victory as he threw six shutout innings.

The Twins are going to be sending young right-hander Taj Bradley to the mound, and he is currently 6-7 with a 4.88 ERA and a 1.30 WHIP in 132.2 innings. He has been struggling to limit the amount of hits against him as he has a .242 batting average against. Bradley faced the Yankees twice this season as a member of the Tampa Bay Rays as he is 1-1 in 10.2 innings and gave up eight runs on 13 hits with seven walks and four strikeouts.

Injury Report for Minnesota

  • Pitcher Justin Topa: Oblique (OUT)
  • Catcher Rya Jeffers: Head (OUT)
  • Left fielder Alan Roden: Thumb (OUT)
  • Catcher Christian Vasquez: Shoulder (OUT)
  • Pitcher Anthony Misiewicz: Shoulder (OUT)
  • Pitcher David Festa: Shoulder (OUT)

New York Yankees vs. Minnesota Twins Pick

Spread Pick for Yankees vs. Twins

  • New York Yankees ML (5 units)

These starting pitchers as of late, show a significant difference as Luis Gil is 4-0 with a 1.89 ERA and a 1.29 WHIP in 38.0 innings in his last seven starts, while Taj Bradley is 0-1 with a 6.33 ERA and a 1.36 WHIP in 21.1 innings during his four starts with the Minnesota Twins. Hitting with runners in scoring position shows a massive gap as the Yankees are tied with the Athletics for 12th with a .764 team OPS in those chances, while the Twins are 29th with a .677 team OPS with runners in scoring position thus far. The Yankees are 8-2 in their previous 10 game,s so go with the New York Yankees to secure the victory.

Over/Under Pick for New York Yankees vs. Minnesota Twins

  • Over (4 units)

Both offenses have been scoring well over the last week of action as New York is averaging 4.57 runs in their previous seven games, while Minnesota is scoring 4.33 runs in their last six games played. These bullpens are struggling throughout the season are not doing too well as the Yankees are 23rd in the majors with a 4.56 reliever ERA while the Twins are 26th with a 4.70 bullpen ERA up to this point. All in all, go with the over as the better bet here.

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