New York Yankees vs. Baltimore Orioles Picks and Prediction for Sunday, September 21, 2025
Our Yankees vs. Orioles prediction sees the New York Yankees (86-68) getting ready to take on the Baltimore Orioles (73-81) in American League East action at Oriole Park at Camden Yards on Sunday afternoon in the final game of a four-game series. This article is being written ahead of Saturday’s game. Rookie right-hander Cam Schlittler gets the start for the Yankees while righty Kyle Bradish pitches for the Orioles. Cover the diamond — MLB picks for New York Yankees vs. Baltimore Orioles in a fast read.
Yankees Looking to Get Closer to Magic Number
The New York Yankees are looking to bounce back after their 4-2 road loss on Friday against the Baltimore Orioles in their last game. The lineup was able to go just 4-for-30 with three walks and 11 strikeouts as Jazz Chisholm hit a home run. The Yankees were 0-for-3 with runners in scoring position and stranded five men on base. Will Warren pitched well despite recording the loss as he gave up three runs (one earned) in 5.1 innings.
Rookie right-hander Cam Schlittler is taking the mound for the New York Yankees and has only made 12 starts this season since being called up. He is 3-3 with a 3.41 ERA and a 1.35 WHIP in 60.2 innings of work. He has been able to keep the ball in the park as he has allowed seven home runs so far. Schlittler is making his first career appearance against the Orioles in this game.
Injury Report for New York
- Pitcher Brent Headrick: Forearm (OUT)
- Pitcher Jonathan Loaisiga: Back (OUT)
- Pitcher Clarke Schmidt: Forearm (OUT)
- Third baseman Oswald Cabrera: Ankle (OUT)
- Pitcher Jake Cousins: Elbow (OUT)
- Pitcher Gerrit Cole: Elbow (OUT)
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Orioles Looking to End the Year Strong
The Baltimore Orioles are coming off a 4-2 home win on Friday over the New York Yankees last time out. The team was holding their own offensively as they were able to go 7-for-31 with three walks and six strikeouts as a whole, with Ryan Mountcastle hitting a homer. Baltimore was 0-for-4 with runners in scoring position and left seven men on base. Trevor Rogers dominated as he pitched six shutout innings in a win.
The Orioles are going to be sending right-hander Kyle Bradish to the mound, and he is currently 1-1 with a 2.45 ERA and a 1.09 WHIP in 22.0 innings in his four starts thus far. He has been able to limit the amount of hits against him as he has a .205 batting average against. Bradish faced the Yankees once last season and did not factor into the decision as he allowed one run on four hits with one hit by pitch, two walks, and five strikeouts in 4.2 innings.
Injury Report for Baltimore
- Pitcher Albert Suarez: Elbow (OUT)
- Pitcher Shawn Dubin: Elbow (OUT)
- Pitcher Brandon Young: Hamstring (OUT)
- Pitcher Felix Bautista: Shoulder (OUT)
- Catcher Gary Sanchez: Knee (OUT)
- Catcher Adley Rutschman: Oblique (OUT)
- Pitcher Zach Eflin: Back (OUT)
- Pitcher Grayson Rodriguez: Elbow (OUT)
- Pitcher Colin Selby: Hamstring (OUT)
New York Yankees vs. Baltimore Orioles Pick
Spread Pick for Yankees vs. Orioles
- New York Yankees ML (5 units)
Cam Schlittler and Kyle Bradish have not been able to give us too much data to go off of this season as both pitchers have been on the mound for limited time this year. The ability to hit with runners in scoring position shows a gap as the Yankees are tied with the Milwaukee Brewers and Tampa Bay Rays for eighth with a .774 team OPS in those chances, while the Orioles are 21st with a .726 team OPS with runners in scoring position, thus far. The Yankees are 3-1 against the Orioles in their previous four games against each other this season, so go with the New York Yankees to win here.
Over/Under Pick for Yankees vs. Orioles
- Under (5 units)
The road/home splits for these starting pitchers have been limited, but they are excelling. Schlittler is 0-1 with a 2.96 ERA and a .192 batting average against in 27.1 innings (five road starts) so far, while Kyle Bradish is 0-1 with a 2.08 ERA and a 0.77 WHIP in 13.0 innings (two home starts) entering Sunday’s action. Both teams are showing the ability to pitch well since the All-Star break as New York is 18th with a 4.33 team ERA in their 58 games, while Baltimore is 12th with a 4.06 team ERA in 59 games so far. The under hit in seven of the eight games they have played so far this season against each other so take the under to hit as well.
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