New York Yankees vs Houston Astros Picks and Prediction for Wednesday, September 3, 2025

Our Yankees vs. Astros prediction sees the New York Yankees (76-61) getting ready to take on the Houston Astros (76-62) in American League action at Daikin Park on Wednesday evening in the middle game of a three-game series. This article is being written ahead of Tuesday’s opening game. Young right-hander Will Warren gets the start for the Yankees while righty Jason Alexander pitches for the Astros. Hit a Grand Slam when utilizing our MLB Picks!

Yankees Looking to Step Up on Tough Stretch of Action

The New York Yankees are coming off a 3-2 road loss on Sunday against the Chicago White Sox last time out. The team was able to go 6-for-33 with six walks and 10 strikeouts on the day as Aaron Judge homered while Trent Grisham stole a base. New York was 1-for-5 with runners in scoring position and left 10 men on base. Luis Gil pitched 5.1 innings and gave up a pair of runs without factoring into the decision.

The Yankees are going to be sending young righty Will Warren to the mound and he is currently 8-6 with a 4.30 ERA and a 1.40 WHIP in 136.0 innings. He has done well throughout the season in terms of limiting the amount of hits, as hitters have a .248 batting average against him. Warren has not faced the Astros in his young career, so this will be an intriguing test for him.

Injury Report for New York

• Pitcher Brent Headrick: Forearm (OUT)
• Left fielder Austin Slater: Hamstring (OUT)
• Pitcher Jonathan Loaisiga: Back (OUT)
• Pitcher Clarke Schmidt: Forearm (OUT)
• Third baseman Oswaldo Cabrera: Ankle (OUT)
• Pitcher Jake Cousins: Elbow (OUT)
• Pitcher Gerrit Cole: Elbow (OUT)

Astros Attacking to Win the AL West

The Houston Astros are looking to build off their 8-3 home win on Monday against the Los Angeles Angels to end their series. The lineup was able to go 12-for-35 with five walks and nine strikeouts as Ramon Urias and Jose Altuve each homered while Jeremy Pena, Cam Smith (x2), Christian Walker, and Jacob Melton all stole a base in the game. The team was 6-for-15 with runners in scoring position and stranded eight on base. Luis Garcia secured the victory as he allowed three runs in six innings of work.

Right-hander Jason Alexander will be getting the start for the Houston Astros and is holding his own as he is 4-1 with a save, 4.61 ERA, and a 1.37 WHIP in 54.2 innings (13 games, eight starts) so far. He needs to improve at keeping the ball in the park a bit more as he allowed nine after giving up 12 in 71.2 innings last year. Alexander faced the Yankees once this season in a victory as he pitched six shutout innings and allowed one hit with three walks and three strikeouts in a victory.

Injury Report for Houston

• Catcher Victor Caratini: Concussion (OUT)
• Pitcher John Rooney: Concussion/Nasal (OUT)
• Pitcher Bennett Sousa: Elbow (OUT)
• Pitcher Brandon Walter: Elbow (OUT)
• Pitcher Josh Hader: Shoulder (OUT)
• Third baseman Isaac Paredes: Hamstring (OUT)
• Second baseman Brendan Rodgers: Oblique (OUT)
• Center fielder Jake Meyers: Calf (OUT)
• Right fielder Zach Dezenzo: Hand (OUT)
• Right fielder Pedro Leon: Knee (OUT)
• Pitcher Ronel Blanco: Elbow (OUT)
• Pitcher Hayden Wesneski: Elbow (OUT)

 

New York Yankees ML (4 units)

When diving into the previous seven starts for these pitchers, there is a slight difference as Will Warren is 2-1 with a 2.68 ERA and a 1.30 WHIP in 37.0 innings, while Jason Alexander is 3-1 with a 3.18 ERA and a 1.21 WHIP in 39.2 innings during that span. There is a gap between these teams when looking at these offenses with runners in scoring position, as New York is 10th with a .767 team OPS with runners in scoring position, while Houston is tied with the St. Louis Cardinals for 20th with a .720 team OPS in those opportunities. All in all, go with the New York Yankees to record the victory on the road.

 

Under (4 units)

When looking into the previous seven days, these are two of the best pitching teams as New York is second in the majors with a 1.76 team ERA, while Houston is fourth with a 2.17 team ERA during that stretch. These bullpens should be able to do well as the Yankees are 21st with a 4.24 reliever ERA while the Astros are ninth with a 3.72 bullpen ERA up to this point. The under is 2-1-1 in their previous four games, so take the under as the better bet to make here.