New York Yankees vs Houston Astros Picks and Prediction for Wednesday, September 3, 2025

By: Robert Antuann Published 09/03/2025, 11:00 AM ET
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Our Yankees vs. Astros prediction sees the New York Yankees (76-61) getting ready to take on the Houston Astros (76-62) in American League action at Daikin Park on Wednesday evening in the middle game of a three-game series. This article is being written ahead of Tuesday’s opening game. Young right-hander Will Warren gets the start for the Yankees while righty Jason Alexander pitches for the Astros. Hit a Grand Slam when utilizing our MLB Picks!

Yankees Looking to Step Up on Tough Stretch of Action

The New York Yankees are coming off a 3-2 road loss on Sunday against the Chicago White Sox last time out. The team was able to go 6-for-33 with six walks and 10 strikeouts on the day as Aaron Judge homered while Trent Grisham stole a base. New York was 1-for-5 with runners in scoring position and left 10 men on base. Luis Gil pitched 5.1 innings and gave up a pair of runs without factoring into the decision.

The Yankees are going to be sending young righty Will Warren to the mound and he is currently 8-6 with a 4.30 ERA and a 1.40 WHIP in 136.0 innings. He has done well throughout the season in terms of limiting the amount of hits, as hitters have a .248 batting average against him. Warren has not faced the Astros in his young career, so this will be an intriguing test for him.

Injury Report for New York

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  • Pitcher Brent Headrick: Forearm (OUT)
  • Left fielder Austin Slater: Hamstring (OUT)
  • Pitcher Jonathan Loaisiga: Back (OUT)
  • Pitcher Clarke Schmidt: Forearm (OUT)
  • Third baseman Oswaldo Cabrera: Ankle (OUT)
  • Pitcher Jake Cousins: Elbow (OUT)
  • Pitcher Gerrit Cole: Elbow (OUT)

Astros Attacking to Win the AL West

The Houston Astros are looking to build off their 8-3 home win on Monday against the Los Angeles Angels to end their series. The lineup was able to go 12-for-35 with five walks and nine strikeouts as Ramon Urias and Jose Altuve each homered while Jeremy Pena, Cam Smith (x2), Christian Walker, and Jacob Melton all stole a base in the game. The team was 6-for-15 with runners in scoring position and stranded eight on base. Luis Garcia secured the victory as he allowed three runs in six innings of work.

Right-hander Jason Alexander will be getting the start for the Houston Astros and is holding his own as he is 4-1 with a save, 4.61 ERA, and a 1.37 WHIP in 54.2 innings (13 games, eight starts) so far. He needs to improve at keeping the ball in the park a bit more as he allowed nine after giving up 12 in 71.2 innings last year. Alexander faced the Yankees once this season in a victory as he pitched six shutout innings and allowed one hit with three walks and three strikeouts in a victory.

Injury Report for Houston

  • Catcher Victor Caratini: Concussion (OUT)
  • Pitcher John Rooney: Concussion/Nasal (OUT)
  • Pitcher Bennett Sousa: Elbow (OUT)
  • Pitcher Brandon Walter: Elbow (OUT)
  • Pitcher Josh Hader: Shoulder (OUT)
  • Third baseman Isaac Paredes: Hamstring (OUT)
  • Second baseman Brendan Rodgers: Oblique (OUT)
  • Center fielder Jake Meyers: Calf (OUT)
  • Right fielder Zach Dezenzo: Hand (OUT)
  • Right fielder Pedro Leon: Knee (OUT)
  • Pitcher Ronel Blanco: Elbow (OUT)
  • Pitcher Hayden Wesneski: Elbow (OUT)

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New York Yankees ML (4 units)

When diving into the previous seven starts for these pitchers, there is a slight difference as Will Warren is 2-1 with a 2.68 ERA and a 1.30 WHIP in 37.0 innings, while Jason Alexander is 3-1 with a 3.18 ERA and a 1.21 WHIP in 39.2 innings during that span. There is a gap between these teams when looking at these offenses with runners in scoring position, as New York is 10th with a .767 team OPS with runners in scoring position, while Houston is tied with the St. Louis Cardinals for 20th with a .720 team OPS in those opportunities. All in all, go with the New York Yankees to record the victory on the road.

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Under (4 units)

When looking into the previous seven days, these are two of the best pitching teams as New York is second in the majors with a 1.76 team ERA, while Houston is fourth with a 2.17 team ERA during that stretch. These bullpens should be able to do well as the Yankees are 21st with a 4.24 reliever ERA while the Astros are ninth with a 3.72 bullpen ERA up to this point. The under is 2-1-1 in their previous four games, so take the under as the better bet to make here.

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