Baltimore Orioles vs. Chicago White Sox Prediction and Picks - September 16, 2025
The MLB is winding down with an end-of-season matchup between the Baltimore Orioles vs. Chicago White Sox; look inside for our prediction and picks. The Baltimore Orioles (70-80, 34-42 away) will take on the Chicago White Sox (57-94, 32-44 home) in the second game of their series on Tuesday, September 16, 2025, at 6:40 PM ET at Guaranteed Rate Field in Chicago, Illinois. The weather is expected to be pleasant, with a temperature of 76°F at game time. Baltimore will send Dean Kremer (9-10, 4.43 ERA, 1.26 WHIP) to the mound, while Chicago counters with Shane Smith (6-7, 3.78 ERA, 1.18 WHIP). The Orioles won the first game of the series 4-1 on September 15, snapping a three-game losing streak, while the White Sox extended their losing streak to four games.
Need a hot take on the MLB Season? Check out our Free MLB Picks and cash in.
Orioles Snap Losing Streak with Solid Performance
The Orioles bounced back from a tough series against the Toronto Blue Jays with a 4-1 victory over the White Sox in the series opener. Gunnar Henderson led the way offensively, going 2-for-4 with a home run and two RBIs, while Jackson Holliday added a solo homer. Baltimore’s pitching staff was stellar, with Kyle Bradish throwing six innings of one-run ball, striking out seven. The bullpen followed with three scoreless innings to secure the win.
Injuries have plagued the Orioles, with key players like Adley Rutschman (10-day IL) and Jordan Westburg (10-day IL) sidelined. Tyler Wells, however, has been a bright spot in limited action, boasting a 2.31 ERA over 11.2 innings pitched. Offensively, the Orioles have struggled, ranking 23rd in MLB with a .239 team batting average and 21st in runs scored (633). Their pitching staff has a 4.58 ERA (24th in MLB), and they average 1.37 WHIP with 4.04 runs allowed per game. Defensively, they commit 0.6 errors per game, ranking in the middle of the pack.
Sign Up for StatSalt News Alerts, Get Free Picks and Discounts
Subscribe Now
White Sox Continue to Struggle
The White Sox dropped their fourth straight game with the 4-1 loss to Baltimore on September 15. Lenyn Sosa provided the lone bright spot offensively, going 2-for-4 with an RBI double. Chicago’s pitching staff performed admirably, with starter Michael Kopech allowing three runs over six innings, but the offense failed to capitalize on scoring opportunities.
Shane Smith has been a reliable arm for Chicago this season, with a 3.78 ERA over 131 innings pitched. Offensively, Lenyn Sosa leads the team with 20 home runs and 68 RBIs, while maintaining a .263 batting average. As a team, the White Sox rank 25th in batting average (.235) and 26th in runs scored (598). Their pitching staff has been slightly better, with a 4.22 ERA (18th in MLB) and a 1.36 WHIP. Defensively, they average 0.7 errors per game, which is slightly worse than Baltimore.
Orioles vs. White Sox Pick
Spread Pick for Orioles vs. White Sox
- Chicago White Sox -1.5 (5 Units)
The Orioles have struggled against the spread recently, covering only 49.7% of games this season. As an away underdog, they’ve been slightly better, covering 58.7% of the time. Meanwhile, the White Sox have covered 58.7% of their games as a home underdog. Baltimore has also struggled after a loss, covering just 50.6% of the time, while Chicago has been more consistent, covering 55.4% of games after a loss. Additionally, the Orioles have a poor record against the run line in non-division games (42.2%), while the White Sox have been more reliable in similar situations (60.2%). Given these trends, the White Sox appear to have the edge against the run line in this matchup. With Shane Smith on the mound and Baltimore’s recent struggles, Chicago is a confident pick to cover the run line. Go with the Sox!
Over/Under Pick for Orioles vs. White Sox
- Under 8.5 (4 Units)
The Orioles have leaned toward the under this season, with 56.9% of their games finishing below the total. They’ve also gone under in 57.1% of games after a loss. The White Sox, on the other hand, have been more balanced, with 48.6% of their games going over the total. However, they’ve hit the over in 57.1% of games as a home underdog. Recent matchups between these two teams have also trended under, with all three games in their earlier series finishing below the projected total. Considering both teams’ offensive struggles and the quality of the starting pitchers, the under is a strong recommendation for this game. Expect a low-scoring affair, with the total runs likely staying below the posted line. Go UNDER and Good Luck!
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
Bet $5 & Get $200 in Bonus Bets Win or Lose
