Philadelphia Phillies vs. Arizona Diamondbacks Picks and Prediction, Friday, September 19, 2025
An NL matchup goes down on Friday, September 19 at 9:40 p.m. ET as the Philadelphia Phillies are on the road to play the Arizona Diamondbacks, so continue reading for our Phillies vs Diamondbacks prediction. Philadelphia is coming off a series win over the Dodgers, while the Diamondbacks took two-of-three from the Giants.
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Phillies Clinched NL East
Philadelphia is 91-62 and has clinched the NL East and has the second-best record in baseball. The Phillies are coming off a series win over the Dodgers, winning the first two games of the series before losing the final game. Philadelphia is hitting .259, which ranks third, while on the road, they are hitting .240. Against Nelson, Harper hits .375 in eight at-bats with a homer, Stott hits .250 in eight at-bats with a homer, Realmuto and Marsh are hitting .200 in five at-bats, Schwarber hits .143 in seven at-bats, and Castellanos hits .143 in seven at-bats.
The Phillies are set to start right-hander Taijuan Walker, who's 5-8 with a 4.17 ERA in 31 games, including 20 starts. In his last outing, he went five innings, allowing four runs against the Royals. Walker is 0-1 with a 9.00 ERA in his career against Arizona. Philadelphia has a team ERA of 3.86, which ranks 10th.
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Diamondbacks Chasing Final Wild Card Spot
Arizona is 77-76 and coming off a series win over the Giants and is 1.5 games back of the New York Mets for the final Wild Card spot. The Diamondbacks are set to start right-hander Ryne Nelson, who's 7-3 with a 3.34 ERA in 31 games, including 21 starts. In his last outing, he went six scoreless innings against the Twins. He's 0-1 with a 4.15 ERA in his career against Philadelphia. Arizona has a team ERA of 4.44, which ranks 23rd.
The Diamondbacks are hitting .251, which ranks 10th, while at home, they are hitting .256. In the month of September, the team is hitting .256. Against Walker, Moreno is 2-for-2 with a homer, Vargas is 1-for-1, Alexander, Perdomo, and McCarthy are 0-for-2, and Carroll is 0-for-1.
Phillies vs. Diamondbacks Pick
- Diamondbacks ML (4 units)
Philadelphia has clinched the National League East but is still looking to track down the Milwaukee Brewers for the top spot in the league. However, this is a good spot for the Diamondbacks to get the win. Walker has struggled on the mound this season, and Arizona's offense is clicking and should be able to hit Walker around. Nelson, meanwhile, has pitched well enough to limit the Phillies' offense for Arizona to get the win.
Over/Under Pick for Phillies vs. Diamondbacks
- Over (4 units)
With how both offenses are hitting the ball right now, the over is a great spot here. Nelson and Walker, meanwhile, have both had their struggles this season and should be hit hard. This season, Arizona is 73-70-10 in hitting the over. In the three games this season, the games are averaging 11.33 runs per game, so look for those trends to continue and the over to hit here.
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