Philadelphia Phillies vs. Arizona Diamondbacks Picks and Predictions, Sunday September 21, 2025
Baseball's post-season race is entering its final weeks, and with so much on the line, both of these teams will be giving their all in our Philadelphia Phillies vs. Arizona Diamondbacks prediction.
The Philadelphia Phillies (92-63) are a team destined for big things in 2025, and with a post-season spot already locked up, they'll be looking to make some major statements against National League rivals in the coming weeks.
On Sunday they finish a series with the Arizona Diamondbacks (78-77), a team that have kept their slim post-season hopes alive, but with some tough competition upcoming, they need to be near perfect down the stretch. Read on to see our Philadelphia Phillies vs. Arizona Diamondbacks prediction.
Expected pitching matchup: LHP Ranger Suarez vs. LHP Eduardo Rodriguez.
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Can the Phillies roll into the post-season with momentum?
The Philadelphia Phillies have been the National League's most consistent team for most of the 2025 campaign, and with a 41-39 record away from home, they've built an untouchable 12 game lead atop the National League East. They've done so behind the bat of Kyle Schwarber, who has tallied an MVP caliber 53 bombs and 129 RBI on the season, and with the stars around him stepping up, this is a team to be feared heading into the MLB Playoffs.
Taking the bump for Philadelphia in this one will be veteran lefty Ranger Suarez, who has excelled to a 2.84 ERA over 24 starts this season, with the 30-year old veteran striking out 145 hitters across 149.0 innings of work in 2025. Last time out for the Phillies was a tough loss to these Diamondbacks, with two hits to Bohm and Schwarber not enough to get the job done as Aaron Nola gave up four runs over 5.1 innings, falling 4-3 on the day.
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Can the Diamondbacks pull off a miracle run?
The Arizona Diamondbacks have been out of the race this season, but they've continued to battle hard, and now with the team sitting one game over .500, they're just two games back of the Mets in the NL Wild Card race. Once more, this team has been defined by their lineups performance, with the team ranking fourth in the league in total runs scored, and with the pitching finding its way as of late, they've got a realistic shot at a post-season run.
In this series finale, Arizona turn to veteran lefty Eduardo Rodriguez, who has struggled to a 5.12 ERA this season, with the 32-year old giving up a massive 166 hits over 142.1 innings of work this season as he looks to keep the D-Backs hopes alive. Last time out for Arizona was a much needed win over the Phillies, with three hits to Jake McCarthy leading the way as Zac Gallen tossed 7.0 stellar innings of three-run ball as this team stayed alive with a 4-3 victory.
Philadelphia Phillies vs. Arizona Diamondbacks picks
Money line pick for Phillies vs. Diamondbacks
- Philadelphia -125 (4 units)
While the Diamondbacks tied up the series with a win on Saturday, it's safe to say that Philadelphia turns to one of baseball's best starters in this one in Ranger Suarez, and with Eduardo Rodriguez posting a 5.12 ERA this season, that's an advantage for the Phillies.
On top of that, the Phillies are up 3-2 in five matchups between these teams in 2025, and with the team being one of the most balanced in baseball, expect them to finish off the series victory with a big win in this one.
Over/Under pick for Phillies vs. Diamondbacks
- Over 8.5 (4 units)
On paper, the strength of both these teams is their offense, and while the over is just 5-5 in their last 10 head-to-head encounters, given what both of these squads thrive on, expect plenty of runs in this one.
For the Phillies, the over is 8-2 in their last 10 overall games, with an average of five runs per game in their last five played on the road, and for the Diamondbacks, the over comes in at 5-5 in their past 10, with 8.5 or more total runs scored in seven games in that time.
Keep it simple, take the over.
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