Philadelphia Phillies vs. Los Angeles Dodgers Picks and Predictions, Tuesday September 16, 2025
At this time of year, every matchup means more to the standings, and on Tuesday we'll see another blockbuster showdown between two World Series favorites in the NL with our Philadelphia Phillies vs. Los Angeles Dodgers prediction.
The Philadelphia Phillies (90-61) are deep, balanced and full of superstars on both sides of the ball, and after building recent momentum, they're heading into the MLB Playoffs as one of the top favorites in the National League.
On Tuesday, they continue their series with the Los Angeles Dodgers (84-66), a team that hasn't been as dominant as expected in recent times, and as a result, they're still in a major fight for the NL West crown in 2025. Read on to see our Philadelphia Phillies vs. Los Angeles Dodgers prediction.
Expected pitching matchup: LHP Cristopher Sanchez vs. RHP Shohei Ohtani.
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Is this the Phillies year to go all the way?
The Philadelphia Phillies have been one of baseball's most consistent teams in 2025, and with a 12-game lead in the National League East, they're ready to prepare themselves for a potentially deep run in the postseason. This season, the Phillies are one of only a few teams that rank in the top 10 in baseball in runs scored and team ERA, and as they sit at .500 on the road, this is a team that's making a case to be a serious contender in 2025.
Taking the mound for Philadelphia in this blockbuster showdown will be star lefty Cristopher Sanchez, who is working on a career-best 2.57 ERA this season, with an impressive 192 strikeouts in 182.1 innings of work, putting him firmly in Cy Young conversations. Last time out for the Phillies was a dramatic win over these Dodgers, with five players driving in a run on the night as the team rode six stellar innings from Ranger Suarez to the 6-5 10th inning victory.
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Can the Dodgers go back-to-back in 2025?
The Los Angeles Dodgers have been on a mission to dominate the National League in recent years, and to this point they've done exactly that, as they've gone 48-27 at home this season to give them a slight edge in the NL West standings. Unsurprisingly, the Dodgers' success in 2025 has come on the back of Shohei Ohtani, who has posted an amazing 49 home runs and 93 RBI on the season, and with the likes of Freddie Freeman and other stars leading the way, this team could be unstoppable down the stretch.
In this one, Los Angeles will turn to their lineup's biggest threat in Ohtani, who has posted a 3.75 ERA in 12 appearances in his first pitching season for the Dodgers, with 49 strikeouts posted in 36.0 innings as he ramps up ahead of the MLB Playoffs. Last time out for the Dodgers was a tough loss to these Phillies, with three RBI to Mookie Betts not enough to get the job done as Jack Dreyer gave up two earned runs in his 1.0 inning of work, leading to the 6-5 extra-inning defeat.
Philadelphia Phillies vs. Los Angeles Dodgers pick
Spread Pick for Phillies vs. Dodgers
- Philadelphia (4 units)
This rivalry is one of the most star-studded in baseball, but after the Philadelphia Phillies' game one win in this series, they've now completely got the upper hand, going 8-2 in their last 10 head-to-head showdowns with the Los Angeles Dodgers.
In four games played in 2025, the Phillies have gone 3-1 to this point, with the total score tied at 17-17 in that time, but with another Cy Young candidate on the mound for Philadelphia, expect their dominance to continue with another win here.
Over/Under pick for Philadelphia Phillies vs. Los Angeles Dodgers
- Over 8.5 (5 units)
While the Phillies rank top-10 in baseball in team ERA, the success of both these teams relies on their offense, with the over being 6-4 in their last 10 head-to-head encounters, with a total of 26 runs scored in their last two games this season.
For the Phillies, the over sits at 7-2-1 in their last 10 overall games, with exactly six runs per game scored during that stretch, and for the Dodgers, the over comes in at 5-5 in that span, with five or more runs allowed in three of their last four overall games.
Keep it simple, take the over.
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