Athletics vs. Boston Red Sox Prediction and Picks - September 16, 2025
The Red Sox will host the Athletics in Boston this Tuesday, and we'll preview the lines and odds in our Athletics vs. Red Sox prediction. These teams are jamming out their second series at the end of the 2025 regular season–the Red Sox won two of three road games against the A's only a week ago. Game 1 of the Boston series is set to start at 6:45 PM ET on Tuesday, September 16.
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Can A's Stay Hot?
With 12 games left in the 2025 regular season, the Athletics sit at 70-80, fourth in the AL West, and – while not yet officially eliminated – firmly outside the MLB playoff picture. That hasn't stopped them from winning each of their last four games, including a 5-4 win to close their home series against the Red Sox and a three-game home sweep of the Cincinnati Reds. Can they keep that momentum against a Red Sox team currently playing for playoff seeding in the crowded AL East?
The Athletics' offense ranks 12th in runs (694), fourth in batting average (.255), and fifth in OPS (.759) among MLB teams this season. Their pitching has let them down–they rank 27th in ERA (4.77), 23rd in batting average allowed (.252), and 26th in WHIP (1.36).
Jeffrey Springs will start for the A's on Tuesday. He's 10-11 this season with a 4.28 ERA, 132 strikeouts, and a 1.20 WHIP, but he's also downturned across recent performances. He's been credited with a 0-3 record in his last three starts: a 2-5 loss to the Rangers, a 1-5 loss at St. Louis, and a 0-6 loss to the Red Sox.
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How Will Sox Close AL East Race?
The Boston Red Sox are third in the AL East at 82-68 overall, one game behind the Yankees and six games behind the Blue Jays. All three are far more likely than not to qualify for the postseason at this rate, but a couple of teams – namely the Texas Rangers and Cleveland Guardians – are ready to hurdle the Red Sox in the standings if they limp to the end of the season. Can they win enough games in the meantime to keep the race interesting, and perhaps earn themselves a high place in the bracket?
Boston ranks sixth among MLB teams in runs (736) and batting average (.254) and eighth in OPS (.748). Their pitching has only been a touch worse, ranking fifth in ERA (3.74) and 17th in both batting average allowed (.245) and WHIP (1.29).
Connelly Early will start for the Red Sox on Tuesday. A 23-year-old pitcher in his first season, Early's first and only MLB appearance thus far ended in a 6-0 win over the Athletics on September 9, during which he struck out 11 of the 21 batters he faced in five innings.
Athletics vs Red Sox Pick
Spread Pick for Athletics vs Red Sox
- Red Sox -1.5 (+130) (4 Units)
The Red Sox dominated the A's through two games of their most recent series, and they're starting the same pitcher who started in their 6-0 win over the Athletics on September 9. Even if the game doesn't go nearly as well for Early, the Red Sox have a lot of room to perform worse than they did and still do enough to win. Boston is the better team and has more to play for here – I'd lean toward them on the run line.
Over/Under Pick for Athletics vs Red Sox
- Under 9.0 (-110) (4 Units)
The Team Total Under went 3-0 in the series between these teams a week ago. It's 5-2 in the A's last seven games and 6-2 in the Red Sox' last eight. The A's were blanked in two of three home games against the Red Sox; I wouldn't expect them to have suddenly found another offensive gear.
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