San Diego Padres vs. Arizona Diamondbacks Picks and Prediction for Thursday, August 6, 2026

The San Diego Padres visit the Arizona Diamondbacks on Thursday at 9:40 PM ET at Chase Field in Phoenix, Arizona. San Diego is 59-55 and sits third in the NL West, 10 games behind the Los Angeles Dodgers. The Padres have won four of their last five games after earning a 9-4 victory on Tuesday to even this series. Arizona is 60-54 and sits second in the NL West, nine games behind Los Angeles. The Diamondbacks have split their last four games and will look to win the series on their home field. Build a bigger bankroll with our free MLB picks.

San Diego Padres Looking to Keep Their Strong Stretch Going

San Diego is batting .236 while scoring 482 runs with 888 hits, 121 home runs, a .312 on-base percentage, and a .384 slugging percentage. Manny Machado leads the Padres with 23 home runs and 69 RBIs, while Fernando Tatis Jr. is batting .280 with 123 hits and 26 stolen bases. Ty France has added 16 home runs while batting .289, Jackson Merrill has contributed 16 home runs and 54 RBIs, and Gavin Sheets has supplied 14 home runs. San Diego has scored 27 runs during its last five games and continues to receive balanced production throughout the lineup.

The Padres have posted a 4.15 ERA and a 1.32 WHIP while limiting opponents to a .247 batting average. San Diego has recorded 922 strikeouts and has received dependable work from both the rotation and bullpen during its recent stretch of success. The pitching staff will look to build on Tuesday's performance after limiting Arizona to four runs.

Injuries: Xander Bogaerts (Day-To-Day), David Morgan (15-Day IL), Samad Taylor (10-Day IL), Lucas Giolito (15-Day IL), Nick Pivetta (60-Day IL).

Arizona Diamondbacks Looking to Respond at Home

Arizona is batting .241 while scoring 517 runs with 922 hits, 110 home runs, a .314 on-base percentage, and a .392 slugging percentage. Ketel Marte leads the Diamondbacks with a .247 batting average, 19 home runs, and 62 RBIs, while Corbin Carroll has contributed 16 home runs and 15 stolen bases. Nolan Arenado has added 16 home runs and 53 RBIs, Gabriel Moreno is batting .298, and Geraldo Perdomo owns a .361 on-base percentage. Arizona will look for a stronger offensive showing after Tuesday's loss.

The Diamondbacks own a 4.20 ERA and a 1.30 WHIP while allowing opponents to bat .254. Arizona's pitching staff has recorded 765 strikeouts and has generally kept the club competitive throughout the season. The Diamondbacks will need a better overall effort after allowing nine runs in the second game of the series.

Injuries: Gabriel Moreno (Paternity), Jordan Lawlar (10-Day IL), Michael Soroka (15-Day IL), Drey Jameson (15-Day IL), Lourdes Gurriel Jr. (10-Day IL).

Pitching Matchup

San Diego Padres – Walker Buehler

Buehler is 6-5 with a 5.18 ERA and a 1.45 WHIP across 104.1 innings. He has allowed 107 hits while striking out 92 batters, walking 44, and surrendering 14 home runs. The veteran right-hander continues to search for more consistent results.

Arizona Diamondbacks – Kohl Drake

Drake is 0-0 with a 4.85 ERA and a 1.46 WHIP over 13.0 innings. The left-hander has allowed 14 hits while striking out 12 batters and walking five. Drake will look to build on his early major league experience.

San Diego Padres vs. Arizona Diamondbacks Game Pick

• San Diego Padres

San Diego enters this matchup with the momentum after winning four of its last five games and producing nine runs in Tuesday's victory. The Padres have received steady offensive production throughout the lineup during this stretch, while Arizona's pitching staff struggled in the previous game. Although neither starter has posted dominant numbers, San Diego has played the more consistent baseball over the past week. Back the Padres to continue their strong run and earn another road victory.

San Diego Padres vs. Arizona Diamondbacks Over/Under Pick

• Over

Both starting pitchers enter with ERAs above 4.80, and Tuesday's matchup produced 13 total runs. San Diego has scored 27 runs over its last five games, while Arizona has enough offensive depth with Ketel Marte, Corbin Carroll, and Nolan Arenado to respond at home. With neither starter showing consistent command this season and both lineups capable of producing extra-base hits, the over is the stronger play.