San Diego Padres vs. Chicago White Sox Picks and Prediction for Saturday, September 20, 2025
Our Padres vs. White Sox prediction sees the San Diego Padres (83-71) getting ready to take on the Chicago White Sox (58-96) in interleague action at Rate Field on Saturday evening in the second game of a three-game series. The White Sox opened the series with a 4-3 home win on Friday. Veteran right-hander Yu Darvish gets the start for the Padres while rookie righty Yoendrys Gomez pitches for the White Sox. From splits to bullpens, MLB predictions for the San Diego Padres vs. the Chicago White Sox highlight the edge.
Padres Looking to Build Towards Playoffs
The San Diego Padres are looking to bounce back after their 4-3 road loss on Friday against the Chicago White Sox to begin their series. The lineup was able to go 7-for-33 with one walk and eight strikeouts as Ramon Laureano stole a base. The Padres were 2-for-7 with runners in scoring position and stranded four men on base. Dylan Cease lost the game as he gave up four runs in six innings on the bump.
Veteran right-hander Yu Darvish is getting the start for the San Diego Padres and has only made 13 starts this season. He is 4-5 with a 5.63 ERA and a 1.14 WHIP in 62.1 innings of work. He has been struggling to keep the ball in the park as he allowed 12 after giving up 12 in 81.2 innings of work. Darvish faced the White Sox once last season in a no-decision as he gave up two runs on three hits with zero walks and nine strikeouts in 6.1 innings of work.
Injury Report for San Diego
- Pitcher David Morgan: Shoulder (OUT)
- Pitcher Nestor Cortes: Elbow (OUT)
- Pitcher Jason Adam: Quad (OUT)
- Shortstop Xander Bogaerts: Foot (OUT)
- Pitcher Jhony Brito: Forearm (OUT)
- Pitcher Joe Musgrove: Elbow (OUT)
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White Sox Looking to Avoid 100 Losses
The Chicago White Sox are coming off a 4-3 home win on Friday over the San Diego Padres last time out. The team was limited offensively as they were able to go 4-for-26 with three walks and seven strikeouts as a whole with Miguel Vargas hitting a homer. Chicago was 2-for-3 with runners in scoring position and left three men on base. Davis Martin recorded the win as he pitched six innings and gave up three runs.
The White Sox are going to be sending rookie right-hander Yoendrys Gomez to the mound, and he is currently 3-2 with a 4.91 ERA and a 1.42 WHIP in 51.1 innings. He has been able to limit the number of hits against him as he has a .234 batting average against. Gomez faced the Padres once last season as a member of the New York Yankees out of the bullpen with a perfect inning with three strikeouts without factoring into the decision
Injury Report for Chicago
- Pitcher Miguel Perez: Shoulder (OUT)
- Pitcher Bryan Hudson: Back (OUT)
- Center fielder Luis Robert Jr: Hamstring (OUT)
- Pitcher Elvis Peguero: Elbow (OUT)
- Pitcher Owen White: Hip (OUT)
- Pitcher Miguel Castro: Knee (OUT)
- Pitcher Drew Thorpe: Elbow (OUT)
- Pitcher Prelander Berroa: Elbow (OUT)
- Pitcher Ky Bush: Elbow (OUT)
San Diego Padres vs. Chicago White Sox Pick
Spread Pick for Padres vs. White Sox
- San Diego Padres ML (5 units)
The Padres have something to play for while the White Sox do not. Yu Darvish and Yoendrys Gomez have both struggled, so let’s take a deeper dive into these teams than the starting pitchers. These bullpens show a gap as San Diego is best in the majors with a 3.08 reliever ERA, while Chicago is 14th with a 4.04 bullpen ERA so far this season. The batting average of balls in play shows a gap as well as the Padres are 15th with a .292 team BABIP, while the White Sox are 27th with a .280 team BABIP. All in all, go with the San Diego Padres to secure the win.
Over/Under Pick for Padres vs. White Sox
- Over (4 units)
These pitchers have struggled in September thus far as Yu Darvish is 1-1 with a 5.52 ERA and a 1.23 WHIP in 14.2 innings (three starts) while Yoendrys Gomez is 0-0 with a 4.20 ERA and a 1.13 WHIP in 15.0 innings (three starts) right now. Since the All-Star break, these teams are swinging the bats well as the Padres are ninth with a .739 team OPS while the White Sox are 13th with a .732 team OPS so far. Go with the over to hit for this game here.
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