San Diego Padres vs Colorado Rockies Picks and Prediction for Friday, September 5, 2025

By: Robert Antuann Published 09/04/2025, 11:55 PM ET
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Our Padres vs. Rockies prediction sees the San Diego Padres (76-64) getting ready to take on the Colorado Rockies (39-101) in National League West action at Coors Field on Friday night in the opening game of a three-game series. Both teams were off on Thursday so they are going to be rested for this game. Right-hander Nick Pivetta gets the start for the Padres while lefty Kyle Freeland pitches for the Rockies. Cover the diamond — MLB picks for San Diego Padres vs Colorado Rockies you can scan fast.

Padres Looking to Compete for Division Lead

The San Diego Padres are coming off a 7-5 home loss on Wednesday against the Baltimore Orioles last time out. The team was able to go 10-for-35 with three walks and 10 strikeouts on the day as Manny Machado and Fernando Tatis Jr homered. San Diego was 2-for-5 with runners in scoring position and left six men on base. Nestor Cortes pitched 2.1 innings and gave up six runs in a losing effort.

The Padres are going to be sending righty Nick Pivetta to the mound and he is currently 13-4 with a 2.84 ERA and a 0.94 WHIP in 158.1 innings. He has done well throughout the season in terms of limiting the amount of hits as hitters have a .188 batting average against him. Pivetta faced the Rockies twice already this season as he is 1-1 in 11.0 innings and allowed six runs on 10 hits with two walks and 17 strikeouts.

Injury Report for San Diego

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  • Pitcher Jason Adam: Quad (OUT)
  • Shortstop Xander Bogaerts: Foot (OUT)
  • Pitcher Michael King: Knee (OUT)
  • Pitcher Jhony Brito: Forearm (OUT)
  • Pitcher Joe Musgrove: Elbow (OUT)

Rockies Still Cold

The Colorado Rockies are looking to bounce back from their 10-8 home loss on Wednesday against the San Francisco Giants to end their series. The lineup was able to go 11-for-36 with two walks and 11 strikeouts as Jordan Beck stole a base in the game. The team was 6-for-13 with runners in scoring position and stranded five on base. German Marquez did not factor into the decision as he pitched five innings and gave up four runs.

Left-hander Kyle Freeland will be getting the start for the Colorado Rockies and is struggling as he is 3-14 with a 5.41 ERA and a 1.52 WHIP in 131.1 innings so far. He needs to improve at keeping hitters off base as he has a .309 batting average against. Freeland faced the Padres once this season in a loss as he pitched five innings and gave up five runs on eight hits with two walks and two strikeouts.

Injury Report for Colorado

  • Pitcher Dugan Darnell: Hip (OUT)
  • Second baseman Thairo Estrada: Hamstring (OUT)
  • Pitcher Seth Halvorsen: Elbow (OUT)
  • Pitcher Zach Agnos: Hand (OUT)
  • Designated hitter Kris Bryant: Lumbar (OUT)
  • Pitcher Jeff Criswell: Elbow (OUT)

Padres vs. Rockies Pick

Spread Pick for Padres vs. Rockies

  • San Diego Padres ML (5 units)

The previous seven starts for these pitchers show a gap as Nick Pivetta is 3-2 with a 2.93 ERA and a 0.79 WHIP in 43.0 innings, while Kyle Freeland is 1-4 with a 6.00 ERA and a 1.53 WHIP in 30.0 innings. These bullpens a on two completely different levels as San Diego is best in baseball with a 3.07 reliever ERA while Colorado is 29th with a 5.30 bullpen ERA right now. The Padres have won five of the six games against the Rockies this season, so take the San Diego Padres to win this game.

Over/Under Pick for Padres vs. Rockies

  • Under (4 units)

These teams are not doing well with runners in scoring position as San Diego is tied with the Kansas City Royals for 25th with a .689 team OPS with runners in scoring position while Colorado is tied with the Pittsburgh Pirates for 28th with a .681 team OPS in those chances. In the previous 30 days, these teams are not scoring too well as the Padres are scoring 4.58 runs in their last 26 games while the Rockies are averaging 3.96 runs in their previous 27 games. All in all, go with the under as the better bet.

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