San Diego Padres vs San Francisco Giants Picks and Prediction for Sunday September 13 2026

The San Diego Padres visit the San Francisco Giants at Oracle Park in San Francisco, California, on Sunday, September 13, 2026. First pitch is scheduled for 7:20 PM ET with coverage on Peacock. San Diego enters at 79-68 overall and 33-39 on the road, while San Francisco is 62-86 overall and 36-37 at home. The Padres won the series opener 7-5 and enter Sunday on a five-game winning streak, while the Giants have dropped back below .500 at home. At the time of this writing the odds were not released. Be sure to check out our free MLB picks for more MLB predictions throughout the season.

Starting Pitchers

San Diego is scheduled to start Nick Pivetta, who enters at 2-2 with a 3.43 ERA and 0.95 WHIP through 21 innings. He has allowed 14 hits and no home runs while recording 26 strikeouts against six walks. San Francisco counters with Logan Webb, who is 8-8 with a 4.10 ERA and 1.15 WHIP across 155.2 innings. He has surrendered 139 hits and 12 home runs while striking out 127 and walking 40. San Diego owns the stronger statistical profile from its scheduled starter, particularly in ERA, WHIP, strikeout rate and home-run prevention, although the sample size is considerably smaller.

San Diego Enters With the Better Momentum

San Diego enters Sunday at 79-68 overall and 33-39 away from home. The Padres have won five straight games, including a 7-5 victory over San Francisco in the series opener. Their other recent wins came by scores of 9-2, 5-4, 3-2 and 4-3. The current streak has included both comfortable wins and close games, giving San Diego plenty of confidence entering another divisional matchup.

The Padres are batting .238 with 626 runs, 1,154 hits and 161 home runs. They own a .315 on-base percentage and .389 slugging percentage. San Diego's pitching staff has produced a 3.89 ERA and 1.28 WHIP while opponents are batting .239. The Padres have recorded 1,200 strikeouts against 499 walks and are 34-22 in day games.

San Diego's biggest strength is its pitching. The Padres have the better team ERA, lower WHIP and significantly better opponent batting average. Their offense has been less impressive in terms of batting average and slugging percentage, but recent run production has improved considerably. With five straight wins and the stronger overall run-prevention numbers, San Diego enters Sunday with a more balanced profile.

San Francisco Has More Offensive Production

San Francisco enters Sunday at 62-86 overall and 36-37 at home. The Giants are 3-2 over their last five games, with victories by scores of 7-6, 2-1 and 5-4 in 11 innings. Their two losses came by scores of 7-5 and 4-2. San Francisco has been competitive recently, but the Giants now face a San Diego team carrying considerably more momentum.

The Giants are batting .247 with 622 runs, 1,240 hits and 167 home runs. They own a .309 on-base percentage and .407 slugging percentage. San Francisco's pitching staff carries a 4.36 ERA and 1.36 WHIP while opponents are batting .248. The Giants have recorded 1,107 strikeouts against 551 walks and are 23-34 in day games.

San Francisco's advantage comes from its offensive profile. The Giants lead San Diego in batting average, hits, home runs and slugging percentage. The concern is pitching, where San Francisco trails in ERA, WHIP and opponent batting average. The Giants have enough offense to make this interesting, but they will likely need a much cleaner pitching performance than they received in the series opener.

San Diego Padres vs San Francisco Giants Picks and Prediction

Pick: San Diego Padres Moneyline

The San Diego Padres Moneyline is the preferred side. San Diego enters on a five-game winning streak, owns the much better season record and already took the series opener 7-5. The Padres also carry the stronger team pitching numbers, with a 3.89 ERA and 1.28 WHIP compared with San Francisco's 4.36 ERA and 1.36 WHIP. San Diego's scheduled starter has also posted the better ERA and WHIP. With the current form and pitching advantage pointing in the same direction, the visitors are the more trustworthy side.

Pick: Under 8.5

Take the Under if the total is set at 8.5 or higher. San Diego owns one of the stronger pitching profiles in this matchup and has held opponents to a .239 batting average, while its scheduled starter enters with a 3.43 ERA and 0.95 WHIP. San Francisco has been involved in several close games recently, including finishes of 2-1 and 4-2. The Giants do have the stronger offensive averages, but the pitching matchup creates enough resistance to support the Under at 8.5 or higher.

Final Picks: San Diego Padres Moneyline and Under 8.5

This preview was completed on Saturday. Starting pitchers, betting lines and other game information are subject to change before the game begins.