San Francisco Giants vs. Arizona Diamondbacks Prediction and Picks - September 15, 2025
San Francisco Giants vs. Arizona Diamondbacks Prediction and Picks - September 15, 2025
The Giants are traveling to Chase Field in Phoenix, Arizona for their series against the Diamondbacks; keep reading for our Giants versus Diamondbacks prediction. San Francisco is third in the NL West with a record of 75-74. Arizona is fourth in the NL West with a record of 75-75. The Diamondbacks are 5-5 versus the Giants this season. The first pitch is scheduled for 9:40 p.m. EDT. Need some winners this baseball season? Check out our Free MLB Picks.
Giants Closing In On Wild Card
The Giants are coming off a loss on Sunday versus the Dodgers with a final score of 10-2. This loss would lose the series for the Giants against the Dodgers 1-2. The Giants have a winning percentage of 0.503 and sit below the bottom wild-card spot held by the Mets, which has a winning percentage of 0.513.
San Francisco still has a chance to overtake the Mets for the final wild card spot, but they are going to need some help. On the season, the Giants have been known for their pitching ranking eighth overall in ERA at 3.84 and leading the league in home runs allowed. However, when their team needed their pitching most to push to a wild card spot, the mound was unable to deliver. The Giants have an ERA of 5.06 in their last ten games and have allowed 3.6 walks per game. Unless the Giants can straighten out their mound and return to their season form, they will likely fall short of the postseason.
Right-handed pitcher Kai-Wei Teng will be starting for the Giants on Monday.
Kai-Wei Teng:
- is 2-4 with an ERA of 7.54 and 28 strikeouts in 6 appearances this season.
- has given up 5 runs on 4 hits with 3 walks in 1 inning versus the Diamondbacks in his career.
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Arizona Finding Wins
The Diamondbacks picked up a win on Sunday versus the Twins with a final score of 6-4. This win would seal the series win against the Twins with a 2-1 record. Arizona was far removed from their chances of making the playoffs but there is still a slim chance they can overtake both the Giants and the Mets for the final wild card spot.
Arizona has relied on their hitting this season to grab wins as its pitching has struggled. At the plate, the Diamondbacks are fifth overall in runs and tenth overall in batting average at .250. The key to the Arizona offense has been their ability to drive the ball for extra bases as they rank fourth overall in slugging percentage at .434 and as a result, sit sixth overall in home runs. While their hitting has been reliable their pitching has not as they rank 23rd overall in ERA at 4.47.
Right-handed pitcher Zac Gallen will be starting for the Diamondbacks on Monday.
Zac Gallen:
- has an 11-14 record with an ERA of 4.84 and 157 strikeouts in 30 appearances this season.
- has a 7-6 record with an ERA of 3.94 and 114 strikeouts in 18 appearances versus the Giants in his career.
San Francisco Giants vs. Arizona Diamondbacks Prediction and Picks
Money Line Pick for San Francisco Giants vs. Arizona Diamondbacks
- Diamondbacks (-142) (4 units)
The Diamondbacks have a record of 8-4 as favorites in their last 12 games against the Giants at home. The Giants have a 3-7 record as underdogs against the NL West on the road this season. San Francisco is having a lot of issues at the mound as of late and I do not see them improving in this matchup. The Diamondbacks have already made short work of Kai-Wei Teng in their last meetup against him where he allowed five runs. I expect the Diamondbacks to grab a much needed win in their race for the wild card.
Over/Under Pick for San Francisco Giants vs. Arizona Diamondbacks
- Over 9.5 (+100) (4 units)
The Diamondbacks have an over/under record of 6-3 in their last nine games. The Giants have an over/under record of 11-5-1 in their last 17 games. San Francisco knows that their pitching has struggled in recent games and that if they wish to find a win in this series they will have to match the Diamondbacks run for run. This is going to be a close game decided by who has the more dominant offense rather than reliable pitching.
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