San Francisco Giants vs. Los Angeles Dodgers Prediction and Picks - September 18, 2025
The Los Angeles Dodgers will host the San Francisco Giants at Dodger Stadium, and we have you ready to go with the Giants vs Dodgers prediction.
Opening Pitch is slated for 10:10 PM Eastern, and the Dodgers have won four of the last five between these two. Read on for the Giants vs Dodgers prediction and more free MLB picks.
This game was written before the completion of Wednesday's action.
Giants Drop 4th Straight
San Francisco saw its troubles continue as it lost its second straight game to the Diamondbacks. The Giants finished with five runs on eight hits, with two players logging multiple hits at the plate. Wilmer Flores led the way with two hits and a home run as the team struck out just three times in the contest. Tristan Beck got the start, and over three innings, he struck out one and allowed three runs.
RHP Logan Webb is expected to take the mound for the San Francisco Giants. Webb will be making his 31st start of the season, and he holds a 14-10 record to go with a 3.31 ERA. Webb has struck out 206 batters while issuing just 43 walks. While he has given up his fair share of hits lately, Webb has struck out seven or more in three of his last four starts. Along with that, he has allowed just one home run over that span.
On the road this season, Webb holds the following splits:
- ERA: 3.54
- Opponent Batting Average (OBA): .270
- BB/K Ratio: 0.24
San Francisco enters this contest averaging 5.0 runs per game, which lands them at 7th in the league. The Giants have struggled with consistency at the plate this season and are currently sitting in the bottom 10 in overall batting average. The Giants have been hitting even more weakly on the road, but more than half of their home runs have come away from home. San Francisco has been hitting their strongest in afternoon games this season. On the plus side, home runs have been coming at a much higher rate than the league average. San Francisco's problems begin at the plate, though. They are sitting in the bottom 10 in strikeout rate, but their ability to hit for extra bases has often made their offense lethal.
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Dodgers Look To Avoid Sweep
Los Angeles has been seeing the ball well, but the pitching staff has allowed 15 runs over the last two games. Most recently, the Dodgers finished with six runs on 10 hits, outdueling Philadelphia by two. Three players finished with multiple hits at the plate as Shohei Ohtani, Alex Call, and Enrique Hernandez all added a home run. Ohtani got the start, and over five innings, he struck out five and allowed no earned runs.
RHP Yoshinobu Yamamoto is slated to start the series for the Los Angeles Dodgers. This season, Yamamoto has made 28 starts, posting an 11-8 record with a 2.64 ERA over 162.2 innings pitched. At home, he holds a 3-4 record with a 3.30 ERA across 62.2 innings. Notably, he maintained a 1.05 WHIP in home games. Yamamoto will look to build on his back-to-back 10 K performances.
At home this season, Yamamoto holds the following splits:
- ERA: 3.30
- Opponent Batting Average (OBA): .215
- BB/K Ratio: 0.28
Los Angeles enters this contest averaging 5.56 runs per game, which lands them at 3rd in the league. The Dodgers struggled with consistency early on this season, but they now sit 3rd in overall batting average. What's more, they've been hitting much stronger in front of their home crowd. They sit 2nd in the league in home runs per game, but they've fallen into the bottom half of the league in strikeouts per game. They've still been able to drive runs home at a high rate, and this has made up for much of their plate inconsistencies.
Giants vs. Dodgers Pick
Side Prediction for Giants vs Dodgers
- Dodgers ML (4 Units)
The Dodgers have seen the ball well this month, and their high home run rate is certainly a tailwind as they face a Giants pitching staff that has struggled to limit hits. The Giants are having a rough month at the plate so far in September, and with their offense sitting in the bottom half of the league in strikeout rate, we should expect them to continue struggling against a Dodgers pitching staff that ranks third in hits allowed.
Los Angeles ML
Total Prediction for Giants vs Dodgers
- Over 8.5 (4 Units)
The Dodgers' offense remains one of the more prolific in baseball, and with their high home run rate, it bodes well for their offense to face off with one of the more inconsistent pitching staffs in the league. San Francisco has logged more than half of their home runs on the road this season, and given that the Dodgers are bottom 10 in strikeout rate, they could string together some multi-run innings here.
Over 8.5
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