San Francisco Giants vs. St. Louis Cardinals Picks and Prediction, Friday, September 5, 2025
In the first game of an NL series between two teams clinging to faint playoff hopes the St. Louis Cardinals (70-71) host the San Francisco Giants (71-69). The Giants are hot and coming of a series sweep and the Cardinals have won two in a row. In this San Francisco Giants vs. St. Louis Cardinals you can get the full score info, pitching matchup, and other free MLB picks.
The Cardinals come into the series opener as a slight favorite posted at -115 with the Giants at +105 and the total sitting at 8 runs.
Giants Need to Stay Hot
The Giants are hot winners of three in a row and 10 of their last 11 games and they need to stay hot, as they are four games out of the NL Wild Card with 22 games remaining in the regular season. They swept the Colorado Rockies in their last series, winning Game 3 10-8, where Matt Chapman had two HR and six other players had an RBI. San Fran likely needs to get the Wild Card to make the playoffs, as they are seven games out of first place in the NL West.
- Chapman (.234 20 HR 54 RBI) played in the last game while appealing a one-game ban in an incident in the previous game and may miss Game 1.
- On the season, the Giants rank sixth in the Majors in team ERA and 20th in runs scored.
- Rafael Devers (.262 30 HR 97 RBI) had gone yard in three straight games before the last one where he did have an RBI.
- Willy Adamas (.230 26 HR 76 RBI) had an RBI in the last game and in the last six games has four HR and 10 RBI.
- On the season, the Giants are 36-35 on the road.
Carson Seymour (0-2 4.74 ERA 1.50 WHIP) gets the start in Game 1 and in his last start he gave up four runs on five hits in three innings in an 11-1 loss to the Baltimore Orioles. The last start was his first of the season, as he has worked out of the bullpen.
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Cardinals Get Better Pitching
After giving up 18 runs in two losses, the Cardinals have gotten much better pitching in winning their last two games, only giving up one run in each. In their last game, they were at home in a 5-1 win over the Athletics, where Willson Contreras was 3 for 4 with four RBI and Nolan Gorman was 3 for 3 with a solo HR. Time is running out for the Cardinals, as they have 21 games left and are out of the NL Central race and 5.5 games out of the Wild Card.
- Like Chapman, Contreras (.254 20 HR 78 RBI), who leads the team in HR and RBI, may miss Game 1, as he is awaiting word on a six-game suspension, which he has appealed.
- On the season, the Cardinals rank 16th in the Majors in runs scored and 20th in team ERA.
- Alec Burlson (.286 16 HR 60 RBI) leads the club in batting average and is out on the 10-day IL.
- On the season, St. Louis is 39-33 at home.
Michael McGreevy (6-2 4.17 ERA 1.19 WHIP) takes the hill for the series opener and was solid in his last start giving up one run on five hits in six innings in a 4-2 win over the Cincinnati Reds. The Cardinals have won five of his last six starts, including his last three where he gave up a total of seven runs in 18 innings.
Giants vs. Cardinals Pick
Spread Pick for Giants vs. Cardinals
- Cardinals -115 (+4 Units)
The Giants are red hot, as they have won three in a row and 10 of 11 games and the Cardinals have won two in a row and are 6-4 in their last 10 games. Both of these teams are clinging to Wild Card hopes, as the Giants are four games out of the Wild Card and the Cardinals are 5.5 games out. The Giants' only loss in their last 11 games is when Seymore got the start, where he was not sharp. The Cardinals have won McGreevy’s last three starts and he was solid in the last one. In terms of the San Francisco Giants vs. St. Louis Cardinals prediction, McGreevy will have the better outing and will be steady, leading the Cardinals to their third win in a row.
Over/Under Pick for Giants vs. Cardinals
- Under 8 runs (+4 Units)
The Giants have totaled 25 runs in their last three games but it was facing the Rockies, who rank last in the Majors in team ERA. McGreevy pitched well in his last start and the Cardinals have won five of his last six starts, including his last three. He will pitch well in this game, facing the Giants and their lineup, which ranks 20th in the Majors in runs scored. Seymore is making his second start after being used as a reliever and was not sharp in his last one. He will give up some runs in this and not last long and unlike his last outing the San Fran bullpen, which ranks second in bullpen ERA, will pitch well. This may not be a pitcher’s duel, but it will also not be a high scoring affair, which is why the Under is the pick.
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