Seattle Mariners vs. Kansas City Royals Picks and Prediction, Wednesday, September 17, 2025
An AL matchup goes down on Wednesday, September 17 as the Seattle Mariners take on the Kansas City Royals at 7:40 p.m. ET, so continue reading for our Mariners vs Royals prediction. This is written before Tuesday's game has ended.
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Mariners Atop AL West
Seattle enters play on Tuesday with a record of 82-68 and is in first place in the AL West, being 0.5 games up on the Astros. The Mariners are hitting .244, which ranks 20th, while on the road, they are hitting .258. Against left-handers, Seattle is hitting .241. Against Ragans, Arozarena is 2-for-2, Crawford is 2-for-3 with a homer, Raley is 1-for-2, while Naylor and Suarez are 1-for-4.
The Mariners are set to start right-hander Bryce Miller, who's 4-5 with a 5.59 ERA. In his last outing, he went 5.2 innings, allowing four runs against the Angels. On the road this season, Miller is 2-3 with a 5.58 ERA. Miller is 0-0 with a 10.00 ERA in his career against the Royals. Seattle has a team ERA of 3.91, which ranks 14th.
Royals Starting Ragans
Kansas City is 75-75 and is coming off a series loss to the Philadelphia Phillies. The Royals are set to start left-hander Cole Ragans, who's 2-3 with a 5.18 ERA in 10 starts this season. Last time out, Ragans went 3 innings, allowing 5 runs against the Cardinals. In his career against the Mariners, he's 0-0 with a 1.29 ERA. Kansas City has a team ERA of 3.73, which ranks fourth.
The Royals are hitting .244, which ranks 19th, while at home, they are hitting .243. Against Miller, Yastrzemski is 1-for-1, Frazier is 3-for-6, Maile and Pasquantino are 1-for-2, Witt Jr. hits .400 in 5 at-bats, while Isbel and Perez are 1-for-4.
Mariners vs. Royals Pick
Money Line Pick for Mariners vs. Royals
- Mariners ML (4 Units)
Although Miller has struggled in his career against the Royals, this is still a good spot to take the Mariners on the ML. Seattle's offense has hit Ragans well, while the left-hander has been hit hard as of late, as he went just 3 innings, so expect the Mariners to get after him. Seattle's bullpen is also better, as the Mariners will be able to lock it down late to get a big win here.
Take Mariners ML.
Over/Under Pick for Mariners vs. Royals
- Over (5 Units)
The over is also a great spot here as Miller has struggled in his career against Kansas City, while Ragans has struggled as of late, which should lead to plenty of runs. This season, Seattle is 81-64-5 in hitting the over, which is the second-best over record in the majors. With how these starters have pitched as of late, the over is a great spot here.
Take the over.