Seattle Mariners vs Pittsburgh Pirates Picks and Prediction for Wednesday June 24 2026

The Seattle Mariners and Pittsburgh Pirates meet on Wednesday, June 24, 2026, at PNC Park in Pittsburgh, Pennsylvania. First pitch is scheduled for 6:40 PM ET, with coverage available on MLB.TV. At the time of this writing the odds were not released. Be sure to check out our free MLB picks.

Starting Pitchers Highlight This Interleague Matchup

Seattle is expected to start Bryan Woo in this contest. Woo enters with a 6-5 record, a 3.94 ERA, and a 1.00 WHIP across 89.0 innings. He has allowed 73 hits, recorded 88 strikeouts, issued 16 walks, and surrendered nine home runs. Pittsburgh is scheduled to counter with Braxton Ashcraft, who comes into the game with a 6-3 record, a 3.18 ERA, and a 1.10 WHIP in 90.2 innings. He has allowed 78 hits, struck out 97 batters, walked 22, and given up eight home runs.

Seattle Looking for Consistency on the Road

The Mariners enter this matchup with a 40-39 overall record and an 18-20 road record. Seattle has gone 2-3 over its last five games. The Mariners recently defeated Boston and Baltimore but also suffered losses to Boston twice and Baltimore during that stretch.

Seattle is batting .232 as a team with 326 runs scored, 606 hits, and 98 home runs. The Mariners own a .313 on-base percentage and a .387 slugging percentage. On the pitching side, they have posted a 3.62 ERA and a 1.18 WHIP while recording 692 strikeouts. Opponents are hitting .239 against Seattle this season.

The biggest strength for Seattle has been its pitching staff. The Mariners have the lower team ERA and WHIP in this matchup, and they have done a strong job limiting opposing hitters. Their 692 strikeouts also demonstrate an ability to generate outs without relying on balls in play.

Pittsburgh Hoping to Continue Strong Offensive Production

The Pirates come into this contest with a 39-39 overall record and a 20-19 home record. Pittsburgh has won three of its last five games, recently earning victories over Colorado and the Athletics twice while suffering losses to Colorado on two occasions.

Pittsburgh is hitting .255 as a team with 391 runs scored, 688 hits, and 94 home runs. The Pirates have also produced a .335 on-base percentage and a .409 slugging percentage. Their pitching staff owns a 4.17 ERA and a 1.31 WHIP while recording 711 strikeouts and allowing opponents to hit .236.

The strength of Pittsburgh has clearly been its offense. The Pirates hold advantages in batting average, runs scored, hits, on-base percentage, and slugging percentage. Those numbers have helped offset a pitching staff that has posted a higher ERA and WHIP than Seattle’s throughout the season.

Seattle Mariners vs Pittsburgh Pirates Picks and Prediction

Seattle Mariners vs Pittsburgh Pirates Pick

• Pick: Pittsburgh Pirates Moneyline

This matchup is extremely competitive, but Pittsburgh gets a slight edge. The Pirates have the advantage in the matchup predictor and bring a more productive offense into the game. While Seattle owns the better team pitching numbers, Pittsburgh counters with stronger offensive production and a projected starter who enters with a lower ERA and more strikeouts than his counterpart. Playing at home also works in the Pirates’ favor.

Seattle Mariners vs Pittsburgh Pirates Total Pick

• Take the under if the total is set at 8.

I would lean toward the under if the total is set at 8. Both projected starters enter with ERAs below 4.00, and Seattle’s pitching staff has been one of the better units in this matchup with a 3.62 ERA and 1.18 WHIP. Pittsburgh’s offense has been productive, but the overall pitching profiles suggest a game that could remain relatively controlled throughout the evening.

Final Score Prediction: Pittsburgh Pirates 4 – Seattle Mariners 3

This prediction was written before the completion of game play on Tuesday.