St. Louis Cardinals vs. Chicago Cubs Picks and Prediction for Saturday, September 27, 2025
Use Code SSWC Our Cardinals vs. Cubs prediction sees the St. Louis Cardinals (78-82) getting ready to take on the Chicago Cubs (90-70) in National League Central action at Wrigley Field on Saturday afternoon in the second game of a three-game series. The Cubs opened the series with a 12-1 home win on Friday. Rookie right-hander Michael McGreevy gets the start for the Cardinals while veteran righty Jameson Taillon pitches for the Cubs. Today’s edge: MLB predictions for St. Louis Cardinals vs. Chicago Cubs built on form and matchups.
Cardinals Looking to End the Season Strong
The St. Louis Cardinals are looking to shake off their 12-1 road loss on Friday against the Chicago Cubs to begin their series. The lineup was able to go 5-for-32 with two walks and 14 strikeouts as a whole. The Cards were 2-for-6 with runners in scoring position and stranded six men on base. Miles Mikolas struggled in a loss as he allowed four runs in five innings of work.
Rookie right-hander Michael McGreevy is getting the start for the St. Louis Cardinals and has only pitched in 16 games (15 starts) this season. He is 8-3 with a 4.35 ERA and a 1.23 WHIP in 91.0 innings of work. He has been keeping the ball in the park as he has allowed 10 home runs so far. McGreevy faced the Cubs twice this season and is 1-0 in 10.2 innings and allowing five runs on 13 hits with two walks and four strikeouts.
Injury Report for St. Louis
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- First baseman Willson Contreras: Shoulder (OUT)
- Shortstop Masyn Winn: Knee (OUT)
- Pitcher Zack Thompson: Lat (OUT)
Cubs Ready for the Playoffs
The Chicago Cubs are coming off a 12-1 home win on Friday over the St. Louis Cardinals last time out. They also learned their wild card opponent, as they will be facing San Diego on Tuesday. The team was excellent offensively as they were able to go 12-for-36 with three walks and seven strikeouts as a whole, with Nico Hoerner, Pete Crow-Armstrong, Michael Busch, and Seiya Suzuki all hitting a homer while Dansby Swanson stole a base. Chicago was 6-for-10 with runners in scoring position and left four men on base. Colin Rea secured the win as he pitched 5.2 shutout innings.
The Cubs are going to be sending veteran right-hander Jameson Taillon to the mound and he is currently 10-7 with a 3.78 ERA and a 1.07 WHIP in 123.2 innings. He has been able to limit the number of hits against him, as he has a .228 batting average against. Taillon faced the Cardinals once this season in a loss as he gave up eight runs on eight hits with two walks and three strikeouts in four innings of work.
Injury Report for Chicago
- Pitcher Cade Horton: Back (Questionable)
- Right fielder Owen Caissie: Concussion (OUT)
- Pitcher Ryan Braiser: Groin (OUT)
- Catcher Miguel Amaya: Ankle (OUT)
- Pitcher Justin Steele: Elbow (OUT)
St. Louis Cardinals vs. Chicago Cubs Pick
Spread Pick for Cardinals vs. Cubs
- Chicago Cubs ML (5 units)
There is a clear difference with how these starters are pitching during September. Michael McGreevy is 2-1 with a 4.91 ERA and a 1.36 WHIP in 22.0 innings (four starts) while Jameson Taillon is 1-1 with a 1.56 ERA and a .206 batting average against in 17.1 innings (three starts) in the calendar month. Hitting with runners in scoring position shows a clear divide throughout the season as Chicago is fourth in MLB with a .791 team OPS in those at-bats, while St. Louis is down at 24th with a .708 team OPS in those chances. The Cubs won six of the last nine against the Cardinals so take the Chicago Cubs to record a win here.
Over/Under Pick for Cardinals vs. Cubs
- Over (4 units)
During the last 15 days, these teams are doing an incredible job in terms of BABIP as the Cardinals are second in that stretch with a .327 team batting average of balls in play, while the Cubs are eighth with a .304 team BABIP so far. In terms of strictly batting average, these teams are getting hits as St. Louis is 18th with a .246 team batting average, while Chicago is 14th in MLB with a .249 team batting average right now. The over has hit in five of the previous seven games against one another, so go with the over too.
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