St. Louis Cardinals vs Milwaukee Brewers Picks and Prediction for Friday, September 12, 2025
Our Cardinals vs. Brewers prediction sees the St. Louis Cardinals (72-75) getting ready to take on the Milwaukee Brewers (89-58) in National League Central action at American Family Field on Friday night in the opening game of a three-game series. Both teams had Thursday off, so they are going to be rested for this game. Young right-hander Andre Pallante gets the start for the Cardinals while young righty Quinn Priester pitches for the Brewers. From splits to bullpens, MLB predictions for St. Louis Cardinals vs the Milwaukee Brewers highlight the edge.
The Cardinals Wanting to Bounce Back
The St. Louis Cardinals are looking to recover from their 4-2 13-inning road loss on Wednesday against the Seattle Mariners to close out their series. The lineup was held to go 8-for-45 with one walk and 14 strikeouts as Ivan Herrera hit a home run while also him and Thomas Saggese stole a base. The team was a brutal 2-for-22 with runners in scoring position and stranded 13 on base. Michael McGreevy did not factor into the decision as he pitched six innings and allowed one run.
Young right-hander Andre Pallante will be getting the start for the St. Louis Cardinals and is struggling as he is 6-13 with a 5.28 ERA and a 1.43 WHIP in 150.0 innings (28 starts) so far. He has done a poor job in terms of keeping the ball in the park, as he has given up 20 home runs after allowing eight in 121.1 innings in 2024. Pallante did not factor into the decision in his only start this season against the Brewers as he pitched 4.1 innings and gave up four runs (three earned) on four hits with one hit by pitch, two walks, and seven strikeouts.
Injury Report for St. Louis
- Shortstop Masyn Winn: Knee (Questionable)
- Pitcher John King: Back (OUT)
- Second baseman Brendan Donovan: Groin (OUT)
- Third baseman Nolan Arenado: Shoulder (OUT)
- Pitcher Zack Thompson: Lat (OUT)
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Brewers Ready to Roll
The Milwaukee Brewers are coming off a 6-3 road loss on Wednesday against the Texas Rangers last time out. The team stepped up offensively as they were able to go 11-for-37 with one walk and 10 strikeouts as Brice Turang and Jackson Chourio each homered while Turang also stole a base. Milwaukee was 2-for-8 with runners in scoring position and left eight men on base. Freddy Peralta recorded the loss as he pitched 5.0 innings and allowed five runs.
The Brewers are going to be sending young right-hander Quinn Priester to the mound, and he is currently 12-2 with a 3.25 ERA and a 1.23 WHIP in 141.1 innings. He has limited the amount of hits against him as he has a .241 batting average against. Priester faced the Cardinals twice already this season as he is 1-0 in 11.0 innings and allowed six runs on 12 hits with one hit by pitch, three walks, and five strikeouts.
Injury Report for Milwaukee
- Pitcher Shelby Miller: Elbow (OUT)
- Pitcher Nick Mears: Back Tightness (OUT)
- Pitcher Trevor Megill: Flexor Strain (OUT)
- Pitcher Logan Henderson: Elbow (OUT)
- Pitcher DL Hall: Oblique (OUT)
- Pitcher Jordan Montgomery: Elbow (OUT)
- Center fielder Garrett Mitchell: Oblique (OUT)
- Pitcher Connor Thomas: Elbow (OUT)
St. Louis Cardinals vs. Milwaukee Brewers Pick
Spread Pick for St. Louis Cardinals vs. Milwaukee Brewers
- Milwaukee Brewers ML (5 units)
There is a significant difference between these two starting pitchers over the course of their previous seven starts. Andre Pallante is 0-6 with a 7.64 ERA and a 1.85 WHIP in 33.0 innings, while Quinn Priester is 3-0 with a 3.18 ERA and a 1.31 WHIP in 39.2 innings during that stretch. The team batting average of balls in play shows a significant difference as Milwaukee is second in MLB with a .305 team BABIP, while St. Louis is 13th with a .293 team BABIP up to this point. Milwaukee is 4-1 in their last five games against St. Louis, so go with the Milwaukee Brewers to secure the win.
Over/Under Pick for St. Louis Cardinals vs. Milwaukee Brewers
- Under (5 units)
These teams are not scoring too well in the last six games entering this matchup, as the Cardinals are scoring 2.67 runs per game while the Brewers are averaging 4.33 runs per game in that stretch. Neither team this season has been able to hit for too many home runs consistently as St. Louis is 28th with 35.75 at-bats per home run, while Milwaukee is 20th with a 31.87 at-bats per homer. All in all, go with the under as the better bet here.
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