St. Louis Cardinals vs Milwaukee Brewers Picks and Prediction for Sunday September 27 2026

The St. Louis Cardinals visit the Milwaukee Brewers at American Family Field in Milwaukee, Wisconsin, on Sunday, September 27, 2026. First pitch is scheduled for 3:10 PM ET with coverage on MLB.TV. St. Louis enters at 77-83 overall and 39-40 on the road, while Milwaukee owns the best record in the NL Central at 101-59 overall and is 53-26 at home. The Brewers lead the division by 13.5 games over Chicago, while St. Louis sits fourth, 24 games behind Milwaukee. The Brewers won Friday's series opener 8-4 for their third consecutive victory, while Saturday's game had not been completed when this preview was prepared and is excluded from the analysis. At the time of this writing the odds were not released. Be sure to check out our free MLB picks for more MLB predictions throughout the season.

Starting Pitchers

St. Louis is scheduled to start Andre Pallante, who enters at 12-8 with a 3.61 ERA and 1.24 WHIP through 157 innings. He has allowed 146 hits and only 11 home runs while recording 106 strikeouts against 49 walks. Milwaukee counters with Jacob Misiorowski, who has been dominant at 15-5 with a 1.86 ERA and 0.80 WHIP through 169.1 innings. He has surrendered only 94 hits and 14 home runs while striking out 247 and walking 42. Pallante has put together a solid season, but Milwaukee has an overwhelming advantage on paper. Misiorowski has the substantially lower ERA and WHIP and has recorded 141 more strikeouts while allowing 52 fewer hits despite throwing more innings.

Cardinals Face a Difficult Assignment in Milwaukee

St. Louis enters Sunday at 77-83 and has lost three of its last four completed games. The Cardinals fell 8-4 in Friday's series opener after losing 2-1 at Pittsburgh. St. Louis' lone victory during those three games was a 5-1 win over the Pirates, while the Cardinals were also shut out 2-0 earlier in that series. Their other victory across the last five was a 5-3 win over Washington. St. Louis has scored 15 runs across those five contests.

The Cardinals are batting .241 with 714 runs, 1,299 hits and 165 home runs. They own a .314 on-base percentage and .380 slugging percentage. The St. Louis pitching staff has produced a 4.26 ERA and 1.35 WHIP with 1,261 strikeouts against 558 walks while allowing opponents to hit .254.

The biggest concern for St. Louis is generating enough offense against Milwaukee's pitching. The Cardinals have been held to one run or fewer in three of their last four games entering the weekend, and their season-long .380 slugging percentage is relatively modest. St. Louis does have 13 more home runs than Milwaukee, but the Cardinals will need baserunners to capitalize on that power. That becomes difficult against a scheduled starter carrying a microscopic 0.80 WHIP.

Brewers Continue to Dominate the NL Central

Milwaukee enters Sunday at 101-59 and has won four of its last five completed games, including three straight. The Brewers defeated St. Louis 8-4 Friday after earning consecutive road victories over Philadelphia by scores of 5-1 and 4-1. Milwaukee's only defeat during its last five was a 6-4 loss to the Phillies, while the Brewers also shut out Baltimore 3-0.

The Brewers are batting .258 with 823 runs, 1,404 hits and 152 home runs. Milwaukee has produced an excellent .340 on-base percentage and .402 slugging percentage. Its pitching staff has been equally impressive, recording a 3.52 ERA and 1.18 WHIP with 1,521 strikeouts against 512 walks while limiting opponents to a .222 batting average.

Milwaukee holds major advantages on both sides of the matchup. The Brewers are batting 17 points higher than St. Louis, have scored 109 more runs and own a 26-point advantage in OBP. Their pitching staff also has an ERA 0.74 runs lower while allowing opponents to hit 32 points worse. Milwaukee has recorded 260 more strikeouts than St. Louis as well. The Cardinals have slightly more home-run power, but virtually every other significant full-season category favors the Brewers.

St. Louis Cardinals vs Milwaukee Brewers Picks and Prediction

Pick: Milwaukee Brewers -1.5

Milwaukee is the preferred side, and the statistical separation is large enough to move from the moneyline to the -1.5 run line if that number is available at a reasonable price. The Brewers are 53-26 at American Family Field and enter on a three-game winning streak, while St. Louis has lost three of four. More importantly, Milwaukee owns a huge starting-pitching advantage. The Brewers' scheduled starter enters with a 1.86 ERA, 0.80 WHIP and 247 strikeouts compared with a solid but clearly inferior 3.61 ERA, 1.24 WHIP and 106 strikeouts for St. Louis' starter. Milwaukee also has significant advantages in team batting average, runs scored, OBP, ERA, WHIP and opponent batting average. After winning Friday's opener 8-4, the Brewers are positioned to create another multi-run victory.

Pick: Under 8.0 or Higher

The under is the preferred total at 8.0 or higher, primarily because of Milwaukee's starting-pitching advantage. The Brewers' scheduled starter has allowed only 94 hits in 169.1 innings while producing a 0.80 WHIP and 247 strikeouts. St. Louis has scored one run or fewer in three of its last four games entering this series and carries only a .380 slugging percentage for the season. The Cardinals' scheduled starter is also capable of keeping the game competitive with a 3.61 ERA and only 11 home runs allowed through 157 innings. Milwaukee's offense is the primary threat to the under, especially after scoring eight Friday, but the two starting pitchers have enough run-prevention ability to make Under 8.0 or higher the preferred total.

Final Picks: Milwaukee Brewers -1.5 and Under 8.0 or Higher

This preview was completed on Saturday, September 26, 2026. Starting pitchers, betting lines and other game information are subject to change before the game begins.