St. Louis Cardinals vs New York Yankees Picks and Prediction for Wednesday August 5 2026
The St. Louis Cardinals will face the New York Yankees at Yankee Stadium in the Bronx, New York, on Wednesday evening. The first pitch is scheduled for 7:05 p.m. ET, with MLB.TV providing television coverage. St. Louis entered Tuesday with a 56-57 record, while New York stood at 63-50. At the time of this writing the odds were not released. Before placing your wagers, check out our free MLB picks for additional baseball predictions throughout the season.
Starting Pitchers
Andre Pallante is expected to start for St. Louis opposite New York right-hander Will Warren. Pallante enters with an 11-6 record and a 3.72 ERA, while Warren owns an 8-5 record with a 4.14 ERA. The Cardinals possess the slightly better starting-pitching profile based on those numbers. Pallante has recorded three more victories and owns an ERA more than four-tenths of a run lower than Warren’s mark.
St. Louis Attempts to Carry Its Power Through the Series
St. Louis entered Tuesday having won three of its previous five games. The Cardinals took one of three games in Toronto before opening this series with a 13-7 victory Monday night. St. Louis built an early 6-0 advantage, surrendered seven unanswered runs, and then responded with seven runs during the eighth inning. The Cardinals finished with five home runs and matched their highest home-run total in a game this season. The series-opening victory improved St. Louis to 56-57.
The Cardinals are averaging approximately 4.4 runs per game while batting .240 as a team. St. Louis has recorded 118 home runs and 67 stolen bases, giving the offense enough balance to create runs through both power and movement on the bases. The pitching staff carries a 4.16 ERA, while opposing hitters are batting .254. Those numbers reflect a team that has remained competitive but has struggled to establish consistent separation from its opponents.
St. Louis’ most important advantage Wednesday could come from Pallante’s stability. His 11 victories and 3.72 ERA give the Cardinals a dependable starter following a series opener in which both bullpens experienced considerable difficulty. St. Louis cannot expect another five-home-run performance, but its lineup should have opportunities against Warren’s 4.14 ERA. If Pallante limits New York during the first five or six innings, the visitors can put themselves in position to win another game at Yankee Stadium.
New York Looks for a Cleaner Pitching Performance
New York entered Tuesday having lost three of its previous five games. The Yankees won two of three contests against Chicago before suffering Monday’s 13-7 defeat. New York showed resilience by erasing a six-run deficit and taking a 7-6 advantage during the seventh inning, but the bullpen surrendered seven runs in the eighth. The Yankees finished with five home runs of their own, yet their pitching staff could not protect the comeback.
The Yankees average approximately 4.6 runs per game while batting .232. New York has produced 162 home runs and 108 stolen bases, comfortably exceeding St. Louis in both categories. The pitching staff owns an impressive 3.37 ERA and has limited opposing hitters to a .226 batting average. Those season-long numbers show why Monday’s 13-run performance from the Cardinals was such an unusual result.
The Yankees’ key will be receiving a longer and more effective appearance from Warren. Monday’s starter lasted only three innings, forcing New York to cover six innings with its bullpen. That workload became increasingly costly as the game progressed. Warren’s 4.14 ERA is respectable, but he must prevent the Cardinals from establishing another early lead. New York possesses enough power to challenge Pallante, especially at home, but its pitching staff needs to avoid the walks and misplaced pitches that fueled St. Louis’ offense Monday.
St. Louis Cardinals vs New York Yankees Picks and Prediction
- Pick: St. Louis Cardinals Moneyline
I am taking St. Louis on the moneyline. New York owns the stronger overall record, better season-long pitching numbers, and home-field advantage, but Pallante gives the Cardinals a narrow edge in Wednesday’s starting matchup. His 11-6 record and 3.72 ERA compare favorably with Warren’s 8-5 record and 4.14 ERA. St. Louis also entered Tuesday playing better recently and demonstrated Monday that it can generate power at Yankee Stadium. I expect a much closer game, but the Cardinals offer the better side behind Pallante.
- Pick: Over 8.5
I also favor Over 8.5 runs if that becomes the posted total. These teams combined for 20 runs and ten home runs Monday, showing the offensive potential available on both sides. Pallante and Warren should provide more stability than the pitching staffs delivered in the opener, but neither starter owns a dominant enough ERA to eliminate the possibility of several early runs. New York has hit 162 home runs, while St. Louis enters with increased confidence following its five-homer performance. I expect both teams to contribute enough offense to push the game over the target number.
This game preview was completed prior to game play on Tuesday.