St. Louis Cardinals vs Seattle Mariners Picks and Prediction for Sunday, September 8, 2025
In the first game of a three-game interleague series, the St. Louis Cardinals are taking on the Seattle Mariners inside T-Mobile Park on Monday night in our Cardinals vs. Mariners prediction. The Cardinals are coming off a 4-3 home win over the San Francisco Giants on Sunday, while the Mariners secured an 18-2 road win over the Atlanta Braves on Sunday. The Cardinals are fourth in the NL Central with a 72-72 record and are sending veteran right-hander Miles Mikolas to the mound. The Mariners are second in the AL West with a 75-68 record and have young righty Bryan Woo getting the ball. Today’s edge: MLB predictions for St. Louis Cardinals vs Seattle Mariners with form and matchup notes.
Cardinals Looking to Get Above .500
The St. Louis Cardinals are looking to continue playing well after their 4-3 home win against the San Francisco Giants on Sunday. The lineup was able to go 8-for-30 with six walks and 13 strikeouts on the day. St. Louis went just 2-for-11 with runners in scoring position and stranded eight men on base. Sonny Gray secured the win as he allowed three runs in 5.1 innings of work.
The Cardinals are going to be sending veteran righty Miles Mikolas to the mound and he is struggling as in 27 starts, he is 7-10 with a 4.89 ERA and a 1.33 WHIP in 136.1 innings of work. He has been giving up hits a bit too much as he has a .274 batting average against up to this point. Mikolas faced the Mariners once last season in a losing effort as he allowed seven runs (six earned) on nine hits with zero walks and three strikeouts in just two innings.
Injury Report for St. Louis
- First baseman Alec Burleson: Wrist (OUT)
- Pitcher John King: Back (OUT)
- Second baseman Brendan Donovan: Groin (OUT)
- Third baseman Nolan Arenado: Shoulder (OUT)
- Pitcher Zack Thompson: Lat (OUT)
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Mariners Slugging Lately
The Seattle Mariners are looking to continue playing well after Sunday’s 18-2 road win against the Atlanta Braves in their most recent game. The Mariners were able to go an outstanding 20-for-45 with three walks and seven strikeouts at the plate as Jorge Polanco, Josh Naylor, Eugenio Suarez (x2), and Cal Raleigh all hit a homer while Naylor and Julio Rodriguez each stole a base. Seattle was 8-for-14 with runners in scoring position while leaving six men on base. Luis Castillo looked sharp as he threw six innings of one-run ball in the victory.
Young right-hander Bryan Woo is going to be taking the mound for the Mariners in this game and has been stepping up as he is 12-7 with a 3.02 ERA and a 0.97 WHIP in 169.2 innings over 27 starts. He has struggled a bit in terms of keeping the ball in the park as he has given up 24 so far after allowing 14 in 121.1 innings last season. This will be Woo’s first career appearance against the Cardinals.
Injury Report for Seattle
- Pitcher Jackson Kowar: Shoulder (OUT)
- Pitcher Trent Thornton: Achilles (OUT)
- Pitcher Logan Evans: Elbow (OUT)
- Pitcher Gregory Santos: Knee (OUT)
- Second baseman Ryan Bliss: Biceps (OUT)
St. Louis Cardinals vs. Seattle Mariners Pick
Spread Pick for St. Louis Cardinals vs. Seattle Mariners
- Seattle Mariners -1.0 (5 units)
The road/home splits show a difference between these starting pitchers as Miles Mikolas is 3-6 with a 6.79 ERA and a .327 batting average against in 59.2 innings (13 road starts) while Bryan Woo is 8-2 with a 2.35 ERA and a 0.83 WHIP in 76.2 innings (12 home starts) right now. The offenses in the last week show a significant difference as Seattle is scoring 7.6 runs in their last five games, while St. Louis is averaging 3.2 runs in their previous five games. The Mariners are 4-2 in their previous six games against the Cardinals so take the Seattle Mariners to secure the win here.
Over/Under Pick for St. Louis Cardinals vs. Seattle Mariners
- Under (5 units)
When diving into the previous seven starts, these pitchers are holding their own as Miles Mikolas is 1-3 with a 4.72 ERA and a 1.43 WHIP in 34.1 innings while Bryan Woo is 4-2 with a 3.25 ERA and a 1.02 WHIP in 43.0 innings during that stretch. These bullpens are looking sharp as the Cardinals are sixth in the bigs with a 3.58 reliever ERA while the Mariners are 11th with a 3.85 bullpen ERA right now. All in all, go with the under as the better bet.
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