Tampa Bay Rays vs Chicago White Sox Picks and Prediction, Wednesday, September 10, 2025
An AL Matchup goes down on Wednesday, September 10, as the Tampa Bay Rays are on the road to play the Chicago White Sox at 7:40 p.m. ET, so continue reading for our White Sox vs Rays prediction. This is written before Tuesday's game has ended.
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Rays Lose Series to Guardians
Tampa Bay is coming off losing three of four to the Cleveland Guardians to fall to under .500. The Rays are hitting .252, which ranks eighth, while in the month of September, after hitting .300. Tampa Bay is hitting .241 on the road, as well.
The Rays are expected to start right-hander Ryan Pepiot, who's 11-10 with a 3.59 ERA in 29 starts this season. Last time out, he went five scoreless innings against the Guardians. Pepiot has never faced the White Sox in his career. Tampa Bay has a team ERA of 3.85, which ranks eighth in the majors.
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White Sox Starting Cannon
Chicago is coming off a series win over the Detroit Tigers, but is 55-89 this season. The White Sox are set to start right-hander Jonathan Cannon, who's 4-9 with a 5.67 ERA in 20 games, including 17 starts. In his last outing, Cannon went 2.1 innings, allowing 5 runs against the Twins, and before that, he went 1.2 innings, allowing seven runs against the Mariners. Cannon has two appearances with the Rays with an 8.68 ERA as he's allowed 10 runs, 9 earned in 9.1 innings. Chicago has a team ERA of 4.23, which ranks 19th.
Offensively, the White Sox are hitting .236, which ranks 27th, while in the month of September, they are hitting .283. Against Tampa Bay, in three games this season, Chicago is slashing .262/.316/.458.
Rays vs White Sox Pick
- Rays ML
Tampa Bay struggled against Cleveland, but this is a good spot for the Rays to get the win here. Cannon has struggled mightily as of late, and the Rays' offense should be able to hit the right-hander hard and give Pepiot an early lead. Pepiot, meanwhile, has pitched well as of late, as he should be able to carve up the White Sox lineup, which has struggled this year.
Take the Rays ML.
Over/Under Pick for Rays vs White Sox
- Over
The over is also a great spot here with Cannon on the mound as he's been shelled in his recent outings, and that should continue here. Cannon has given up 5+ runs in all four of his recent innings, with the longest outing going 6 innings. This season, the White Sox are 38-29-5 in hitting the over at home, as their park has been a good over spot this season. Look for those trends to continue, so take the over here.
Take the over.
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