Toronto Blue Jays vs Baltimore Orioles Picks and Prediction for Wednesday September 23 2026

The Toronto Blue Jays visit the Baltimore Orioles at Oriole Park at Camden Yards in Baltimore, Maryland, on Wednesday, September 23, 2026. First pitch is scheduled for 6:35 PM ET with coverage on MLB.TV. Toronto enters at 77-80 overall and 37-42 on the road, while Baltimore is 76-81 overall and 37-42 at home. The Orioles won Monday's series opener 4-3 and held a 1-0 advantage in the three-game series entering Tuesday's action. Toronto has dropped three of its five most recently completed games, while Baltimore snapped a three-game losing streak with Monday's victory. At the time of this writing the odds were not released. Be sure to check out our free MLB picks for more MLB predictions throughout the season.

Starting Pitchers

Neither Toronto nor Baltimore had a probable starting pitcher listed in the information available for Wednesday's series finale. That makes the pitching matchup an important variable to monitor before placing a wager. Toronto owns the stronger season-long pitching numbers with a 3.92 team ERA and 1.30 WHIP, compared with Baltimore's 4.11 ERA and 1.34 WHIP. Without confirmed starters, however, there is not enough information to make a pitcher-specific comparison or assume either team will have a meaningful starting-pitching advantage.

Toronto Looks to Turn Around Its Road Trip

Toronto enters Wednesday at 77-80 overall and 37-42 away from home. The Blue Jays lost Monday's series opener 4-3 after taking one of three games in Texas. Toronto is 2-3 across its five most recently completed games, with victories of 7-2 and 5-1 mixed around losses of 4-3, 6-2 and 7-1. The Blue Jays have scored 18 runs and allowed 20 over that stretch, reflecting how close their recent results have been outside of a couple of more decisive defeats.

The Blue Jays are batting .248 with 632 runs, 1,311 hits and 149 home runs. Toronto owns a .310 on-base percentage and .382 slugging percentage. Its pitching staff has been the stronger part of the statistical profile, carrying a 3.92 ERA and 1.30 WHIP while issuing 581 walks and recording 1,365 strikeouts. Opponents are batting only .236 against Toronto pitching, which is considerably better than Baltimore's .252 opponent batting average.

Toronto's challenge is turning its ability to reach base and collect hits into enough runs. The Blue Jays have 87 more hits than Baltimore and hold a 14-point advantage in batting average, yet they have scored 65 fewer runs. Toronto also trails Baltimore by 43 home runs. That lack of comparable power has limited the Blue Jays' offensive ceiling, making run prevention especially important when they are facing a Baltimore club capable of changing a game with one swing.

Baltimore Tries to Build on Series-Opening Victory

Baltimore comes into Wednesday at 76-81 overall and 37-42 at Camden Yards. The Orioles earned a 4-3 victory over Toronto on Monday after being swept in three games at home in their previous series. Baltimore is 2-3 over its five most recently completed games, scoring 16 runs while allowing 15. Three of those games were decided by one run, including Monday's win, showing how frequently the Orioles have been involved in close contests recently.

The Orioles are batting .234 with 697 runs, 1,224 hits and 192 home runs. They have a .314 on-base percentage and .395 slugging percentage. Baltimore's pitching staff owns a 4.11 ERA and 1.34 WHIP with 525 walks and 1,269 strikeouts. Opposing hitters are batting .252 against the Orioles. The most striking offensive comparison is Baltimore's ability to produce considerably more runs despite recording fewer hits than Toronto.

Power has been Baltimore's most significant statistical advantage in this matchup. The Orioles have hit 192 home runs compared with Toronto's 149, and their .395 slugging percentage also exceeds the Blue Jays' .382 mark. Baltimore's pitching numbers are not as strong, so the Orioles may need that power advantage again Wednesday. Monday's 4-3 victory showed they can win a tight game against Toronto, and the nearly identical overall and home-road records suggest there is very little separation between these teams outside of their different offensive profiles.

Toronto Blue Jays vs Baltimore Orioles Picks and Prediction

Pick: Baltimore Orioles Moneyline

Baltimore gets a slight lean in what projects as another competitive matchup. The Orioles have the more dangerous power profile with 192 home runs and 697 runs scored, compared with 149 homers and 632 runs for Toronto. Baltimore also took Monday's opener 4-3 and is playing at home, although its 37-42 home record prevents this from being a particularly strong home-field angle. Toronto has the better pitching numbers, so the absence of confirmed starters keeps this from being a high-confidence side. Based on the information currently available, Baltimore's superior run production and power make the Orioles the preferred moneyline side.

Pick: Under 9 or Higher

The under is the preferred total if sportsbooks post 9 or higher. Toronto has allowed only 20 runs over its last five completed games, while Baltimore has surrendered 15, and Monday's opener finished with seven combined runs. Toronto's season-long 3.92 ERA and .236 opponent batting average also provide support for a lower-scoring projection. Baltimore's power creates obvious risk, especially with neither starter confirmed, but Toronto has not consistently generated enough offense to force high totals. At 9 or better, there is enough margin to favor the under while waiting for the starting-pitching matchup to become official.

Final Picks: Baltimore Orioles Moneyline and Under 9 or Higher

This preview was completed on Tuesday, September 22, 2026. Starting pitchers, betting lines and other game information are subject to change before the game begins.