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Cleveland Cavaliers at San Antonio Spurs Predictions, Picks, Odds, and Line Movement for December 29 2025

By: Kyle Kargel Published 12/29/2025, 10:37 AM ET

Cavaliers vs Spurs picks headline this Monday NBA matchup, and I’m breaking down the betting angles using only market data, recent results, and situational context. This Cavaliers vs Spurs prediction focuses on line movement, ATS performance, and matchup-specific factors while aligning with my daily NBA picks process.

TLDR - Picks and Prediction

  • Spread Pick: Spurs +3
  • Total Pick: Under 242.5
  • Projected Final Score: Spurs 121, Cavaliers 118

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  • Cleveland has won six straight meetings against San Antonio, including a 13-point home win three weeks ago.
  • The Cavaliers are 9-24 against the spread this season.
  • Cleveland is just 4-10 ATS in road games.
  • San Antonio is coming off a home loss as a 13-point favorite against Utah.
  • Both teams are on equal rest after playing Saturday.
  • Victor Wembanyama has not played in the last three meetings with Cleveland.

Odds and Line Movement

Current Odds

Team Spread Total
Cleveland -3 (-110) Over 242.5 (-108)
San Antonio +3 (-110) Under 242.5 (-112)

Line Movement - Spread

Date Time Cleveland San Antonio
12/29 08:37 AM -3 (-110) +3 (-110)
12/29 08:31 AM -3 (-108) +3 (-112)
12/29 08:26 AM -3 (-114) +3 (-106)
12/29 01:38 AM -4 (-114) +4 (-106)
12/29 01:37 AM -4 (-112) +4 (-108)
12/29 01:37 AM -4 (-110) +4 (-110)
12/29 01:29 AM -4.5 (-110) +4.5 (-110)
12/29 01:26 AM -4 (-110) +4 (-110)
12/28 07:18 PM -4.5 (-110) +4.5 (-110)
12/28 07:00 PM -4.5 (-112) +4.5 (-108)
12/28 06:50 PM -4 (-106) +4 (-114)
12/28 06:19 PM -4 (-108) +4 (-112)
12/28 02:35 PM -4.5 (-110) +4.5 (-110)
12/28 12:53 PM -5 (-110) +5 (-110)
12/28 12:53 PM -5.5 (-115) +5.5 (-105)
12/28 11:54 AM -5.5 (-112) +5.5 (-108)
12/28 06:21 AM -5.5 (-110) +5.5 (-110)
12/28 01:14 AM -5 (-110) +5 (-110)

Line Movement - Total

Date Time Over Under
12/29 10:03 AM 242.5 (-108) 242.5 (-112)
12/29 10:02 AM 242.5 (-110) 242.5 (-110)
12/29 07:43 AM 241.5 (-110) 241.5 (-110)
12/28 09:14 PM 240.5 (-114) 240.5 (-106)
12/28 07:18 PM 242 (-106) 242 (-114)
12/28 02:35 PM 242 (-105) 242 (-115)
12/28 11:50 AM 242 (-115) 242 (-105)
12/28 01:14 AM 242.5 (-110) 242.5 (-110)

Cavaliers vs Spurs Game Preview and Analysis

Cleveland enters this matchup on a three-game skid and continues to struggle against the number. Even with six straight wins over San Antonio in the series, this spot is less appealing given the Cavaliers’ road ATS profile and mounting injuries.

San Antonio is coming off an embarrassing home loss to Utah as a 13-point favorite, but the market has shown steady support for the Spurs since opening night. The spread has dropped from Cleveland -5.5 down to -3, signaling resistance to laying points with a poor ATS team away from home.

De’Aaron Fox’s availability is critical. San Antonio looked disjointed without him against Utah, but if he plays, this offense is far more functional. With both teams on equal rest and Cleveland missing rotation pieces, I’m comfortable grabbing the points with the Spurs.

Key Injuries and Notes (CLE vs SA)

  • CLE: Larry Nance Jr. remains out.
  • CLE: Max Strus remains out.
  • SA: De’Aaron Fox is questionable.

Final Score Prediction

San Antonio 121, Cleveland 118

ATS and Total Picks

  • ATS: Spurs +3
  • Total: Under 242.5
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