Detroit Pistons vs Indiana Pacers Predictions, Picks, Odds and Trends for November 24

By: Josh Collacchi Published 11/24/2025, 08:57 AM ET
Pistons star Cade Cunningham
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Looking for a Detroit Pistons vs Indiana Pacers prediction? We have you covered, including line movement history, key matchups, ATS and total picks, and a projected final score. For more NBA previews and analysis, check out our NBA predictions.

Quick Picks and Prediction: Detroit Pistons vs Indiana Pacers

  • Side: Detroit Pistons -9.5
  • Total: Over 235.0
  • Projected Final Score: Detroit Pistons 127, Indiana Pacers 116
  • Confidence (0–3): Side 1.5 / Total 1.5

Odds and Line Movement: DET vs IND

FanDuel lists Detroit as a sizeable road favorite with a total in the mid 230s. Below is the complete spread and total movement based on the latest available market updates.

Line Movement - Spread

Date Time Detroit Indiana Public ($, #)
11/23 10:54:09pm -9½ (-110) +9½ (-110)
11/23 09:37:09pm -10 (-110) +10 (-110)
11/23 09:33:59pm -9½ (-112) +9½ (-108)
11/23 08:53:05pm -9½ (-114) +9½ (-106)
11/23 07:18:44pm -9 (-110) +9 (-110)
11/23 06:49:58pm -8½ (-114) +8½ (-106)
11/23 06:47:27pm -8 (-110) +8 (-110)

Line Movement - Total

Date Time Over Under Public ($, #)
11/24 07:40:10am 235 o(-110) 235 u(-110)
11/23 06:53:20pm 234½ o(-110) 234½ u(-110)
11/23 06:47:27pm 233½ o(-110) 233½ u(-110)

Key Matchups and Handicap: Detroit Pistons vs Indiana Pacers

These teams just played last Monday when Detroit secured a 127-112 home win as an 8.5 point favorite. Prior to that result, Indiana had dominated the matchup, winning and covering seven of the previous eight meetings. The Pacers enter this rematch off a full weekend of rest, which should help them reset after the recent loss.

Detroit remains one of the hottest teams in the league, going 12-0 straight up and 10-2 against the spread over its last ten games. The Pistons offense has been rolling, and five of Detroit’s last six games have gone over the total. That scoring surge has come with improved health, and both teams appear close to full strength entering this matchup. The only injuries listed on the early report are the long term absences for Marcus Sasser, Obi Toppin, and Kam Jones.

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The interesting dynamic in this matchup is identity: Detroit continues to ride an up tempo rhythm on offense, while Indiana’s defense has struggled to contain explosive guards and transition scoring. With Detroit’s recent form and the Pacers still searching for consistency, the Pistons enter with both momentum and matchup advantages despite being on the road. Indiana should be fresher, but Detroit’s ten game heater cannot be ignored.

  • Detroit is 12-0 straight up in its last twelve games.
  • The Pistons are 10-2 against the spread in that stretch.
  • Five of Detroit’s last six games have gone over the total.
  • Prior to last week, Indiana had won and covered seven of the previous eight meetings.
  • Detroit won Monday’s meeting 127-112 as an 8.5 point favorite.

Key Injuries and Notes: DET vs IND

  • Detroit: Long term injuries only (Marcus Sasser, Obi Toppin, Kam Jones).
  • Indiana: No new injuries listed on the early report.

ATS and Total Picks: Detroit Pistons vs Indiana Pacers

Detroit’s form, offensive rhythm, and recent dominance push the handicap toward the Pistons once again, while the scoring profile points toward another high total.

Spread Pick — Pistons vs Pacers

  • Pick: Detroit Pistons -9.5
  • Why: Detroit is 12-0 straight up and 10-2 against the spread with strong offensive consistency, and already handled Indiana by 15 earlier this week.

Total Pick — Detroit vs Indiana

  • Pick: Over 235.0
  • Why: Five of the Pistons last six have gone over, and Indiana’s defense has struggled to contain Detroit’s tempo driven attacks.

Final Score Prediction: Detroit vs Indiana

Detroit Pistons 127, Indiana Pacers 116

Detroit’s winning streak and offensive momentum give them the edge in this rematch. Indiana should respond better with added rest, but the Pistons aggressive playmaking, pace, and shot creation create too many challenges for a Pacers defense still trying to stabilize. Expect long stretches of efficient offense from Detroit and another matchup that leans toward the higher side of the total.

How to Bet: Detroit Pistons vs Indiana Pacers

Pistons bettors should target spreads around -9.5 or better, while Indiana backers will want any upward movement above +10. On the total, over bettors should secure numbers in the 234.5 to 235 range before any further rise. Check updated odds and projections before tipoff.

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