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LA Clippers vs Memphis Grizzlies Prediction and Picks - December 5, 2025

By: Dean Whitaker Published 12/04/2025, 11:38 PM ET
Zach Edey looks to lead the Grizzlies over the Clippers

Friday night NBA action within the Western Conference, and we have an LA Clippers vs Memphis Grizzlies prediction locked and loaded for you. The Clippers enter this contest off a 115-92 road win over Atlanta to improve to 6-16 on the year. Memphis checks in off a 126-119 road loss to the Spurs, and they are now 9-13 on the season. These teams met back in November and the Grizzlies won that game on the road by a score of 112-107. Read on to see our Clippers vs Grizzlies prediction.

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Clippers Rout The Hawks On The Road

The Clippers’ most recent game was a 115–92 win over the Atlanta Hawks on December 3, their first victory after parting ways with Chris Paul. James Harden led the way with 27 points and nine assists, while Kawhi Leonard chipped in 21 points, six rebounds, and five assists. Ivica Zubac was a force inside, pulling down 17 rebounds, and the team looked energized in their first outing without CP3.

Offensively, the Clippers average 112.5 points per game (25th), shooting 47% from the field (16th) and 35.5% from three (18th). Harden has been the focal point, averaging nearly 27 points and eight assists per game, while Leonard continues to provide steady scoring and defensive versatility. Zubac’s rebounding presence has been critical, though the team ranks just 25th in boards at 41.7 per game, often struggling to control the glass against bigger lineups. Their free‑throw shooting has been elite at 84.3% (1st), which helps them stay competitive in close games.

Defensively, Los Angeles allows 117.6 points per game (20th) and opponents to shoot 47.5% from the field (21st). Their biggest weakness has been defending the perimeter, where they give up 39% from three (29th), one of the worst marks in the league. Despite that, they rank 8th in rebounds allowed (43 per game), showing some ability to limit second‑chance opportunities. With Chris Paul’s departure, the Clippers are leaning heavily on Harden and Leonard to stabilize the offense and defense, and their win in Atlanta was a step in the right direction.

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Grizzlies Fall To Spurs On The Road

Memphis’ last game was a 126–119 loss to the San Antonio Spurs on December 2, where Harrison Barnes scored 31 points for the Spurs, while Zach Edey led the Grizzlies with 19 points and 15 rebounds. Cam Spencer added 21 points, but Jaren Jackson Jr. was limited to just seven points in the defeat.

The Grizzlies average 113.7 points per game (23rd) while shooting 44.5% from the field (27th) and 33.7% from three (27th). Their offense has been inconsistent without Ja Morant, who remains day‑to‑day with a calf injury. Edey has been a bright spot, providing size and rebounding, while Spencer and Jaylen Wells have stepped up as perimeter threats. Memphis ranks 8th in rebounding at 46.5 per game, giving them second‑chance opportunities, and they’ve been strong at the free‑throw line, hitting 81.1% (7th).

Defensively, Memphis allows 117 points per game (18th) and opponents to shoot 47.5% from the field (20th). Their perimeter defense has been shaky, giving up 37.2% from three (25th), though they excel at limiting free‑throw attempts, ranking 5th in opponent FT% (77.4%). Jaren Jackson Jr. remains their defensive anchor, but the team has struggled to find consistency without Morant’s offensive spark. Against the Clippers, Memphis will look to lean on Edey’s rebounding and Jackson’s defense to slow Harden and Leonard, hoping to bounce back at home.

LA Clippers vs Memphis Grizzlies Pick

Clippers vs Grizzlies Spread Pick

  • LA Clippers -2 (5 Units)

The Clippers -2 feels like the right side because they’re coming off a convincing 115–92 win over Atlanta, where James Harden and Kawhi Leonard combined for 48 points and Ivica Zubac dominated the glass with 17 rebounds. That performance showed how quickly they’ve adjusted after parting ways with Chris Paul, leaning on Harden’s playmaking and Leonard’s two‑way impact to stabilize the lineup. Los Angeles may not be an elite scoring team overall (112.5 points per game, 25th), but their efficiency is solid at 47% from the field and they lead the league in free‑throw shooting (84.3%), which gives them an edge in tight games. Against a Memphis squad that’s still waiting on Ja Morant to return, the Clippers’ veteran core looks well‑positioned to control tempo and grind out another win.

Memphis has dropped three of their last four and just fell 126–119 to San Antonio, struggling to contain Zach Edey inside despite his own 19‑point, 15‑rebound effort. Without Morant, the Grizzlies’ offense has been inconsistent, shooting just 44.5% from the field (27th) and 33.7% from three (27th), and they’ve leaned heavily on Jaren Jackson Jr. and Cam Spencer to keep them afloat. Defensively, Memphis allows 117 points per game (18th) and opponents to shoot 47.5% (20th), which is a dangerous matchup against Harden and Leonard’s efficiency. The Clippers’ ability to exploit Memphis’ perimeter defense (37.2% allowed from three, 25th) and their own momentum from the Atlanta win make laying the -2 a strong angle, as Los Angeles has the veteran firepower to close late.

Clippers vs Grizzlies Over/Under Pick

  • Under 224 (4 Units)

The Under 224 looks sharp because both the Clippers and Grizzlies have struggled to generate consistent offensive firepower, and their defensive profiles point toward a slower, grind‑it‑out type of game. Los Angeles averages just 112.5 points per game (25th) and ranks near the bottom in rebounding, which limits second‑chance scoring opportunities, while Memphis sits at 113.7 points per game (23rd) with poor shooting efficiency (44.5% FG, 27th; 33.7% 3PT, 27th). Even though both defenses allow over 117 points per game, neither team plays at a breakneck pace, and the absence or limited status of Ja Morant further dampens Memphis’ offensive ceiling. With the Clippers leaning on Harden and Leonard to control tempo and the Grizzlies relying on Edey and Jackson inside, this matchup profiles more as a half‑court battle than a shootout, making the Under 224 the right angle.

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