Los Angeles Lakers vs Philadelphia 76ers Prediction and Picks - December 7, 2025
Sunday evening NBA action, and we have a Los Angeles Lakers vs Philadelphia 76ers prediction locked and loaded for you. The Lakers enter this contest off a 126-105 loss to the Celtics on the road to fall to 16-6 on the year. The Sixers enter this contest at 13-9 and they are off a 116-101 road win over Milwaukee. These teams split the two meetings a year ago. Read on to see our Lakers vs 76ers prediction.
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Lakers Fall Big To Boston
The Lakers’ most recent game was a 126–105 loss to the Boston Celtics on December 5, where Austin Reaves carried the offense with 36 points and eight assists, but the team was shorthanded without LeBron James and Luka Doncic. Gabe Vincent added 18 points, yet Boston’s barrage of 24 made threes buried Los Angeles early, and the Lakers never recovered from a 39–17 first quarter deficit.
Offensively, Los Angeles has been one of the league’s most efficient teams, averaging 118.6 points per game (10th) while shooting 50.9% from the field (2nd). Luka Doncic leads the NBA in scoring at 35.3 points per game, while Reaves has stepped up with 29.3 points per game over the last 10 contests. The Lakers hit 35.8% from three (17th) and are strong at the line (80.5% FT, 10th), but their rebounding has been a weakness at just 40.5 per game (27th). Depth scoring from Rui Hachimura and Nick Smith Jr. has helped, but the team’s ceiling depends on the availability of James and Doncic.
Defensively, the Lakers allow 116.5 points per game (17th) and opponents shoot 48.6% (25th), with particular struggles defending the perimeter (38.0% allowed, 25th). Deandre Ayton has provided rebounding and rim protection, but the team ranks just 2nd in fewest rebounds allowed (39.0), showing they can limit second‑chance opportunities even if their initial defense falters. With James and Doncic both listed day‑to‑day, the Lakers’ ability to cover gaps with Reaves’ scoring and Vincent’s perimeter shooting will be critical against Philadelphia’s balanced attack.
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Grimes Leads Sixers Over Bucks
The 76ers’ most recent game was a 116–101 win over the Milwaukee Bucks on December 5, where Quentin Grimes scored 22 points off the bench and Paul George added 20 points with five rebounds and five assists. Tyrese Maxey was held to just 12 points, but Philadelphia’s depth carried them, outscoring Milwaukee’s reserves 53–28 to secure their third straight victory.
Offensively, Philadelphia averages 117.4 points per game (16th) while shooting 46.1% from the field (20th) and 36.2% from three (14th). Maxey has been the star, averaging 31.6 points and 7.1 assists, while George’s return from injury has added another scoring option. Quentin Grimes has been hot, averaging 22 points over his last 10 games, and Jabari Walker has provided spacing with timely shooting. The Sixers rebound well at 44.5 per game (14th), giving them balance across the board.
Defensively, Philadelphia allows 116.4 points per game (15th) but holds opponents to 46.3% shooting (10th) and just 34.2% from three (7th), making them one of the better perimeter defenses in the league. Joel Embiid remains day‑to‑day with a knee issue, and Kelly Oubre Jr. is sidelined with a knee injury, but the Sixers have managed to stay competitive thanks to Maxey’s scoring and George’s two‑way play. With three straight wins and home‑court advantage, Philadelphia enters this matchup confident, though they’ll need Embiid’s presence to match the Lakers’ star power if James and Doncic return.
Los Angeles Lakers vs Philadelphia 76ers Pick
Lakers vs 76ers Spread Pick
- Philadelphia +4 (4 Units)
The Sixers +4 looks like a sharp play because they’re coming off a 116–101 win over Milwaukee on December 5, where Quentin Grimes poured in 22 points off the bench and Paul George added 20 with five rebounds and five assists. Even with Tyrese Maxey held to just 12 points, Philadelphia’s depth carried them, outscoring the Bucks’ reserves 53–28. That kind of balance is critical against a Lakers team that leans heavily on its stars, especially with LeBron James and Luka Doncic both dealing with injuries. The Sixers average 117.4 points per game and shoot 36.2% from three, giving them enough offensive firepower to keep pace even if Maxey isn’t at his best.
The other angle is Philadelphia’s defense, which ranks 7th in opponent three‑point percentage (34.2%) and has been strong at limiting perimeter looks. That’s a key matchup against a Lakers squad that just lost 126–105 to Boston, allowing 24 threes while struggling to defend the arc. Los Angeles has been efficient offensively all season (50.9% FG, 2nd in the NBA), but their defense has been shaky, giving up 116.5 points per game and ranking near the bottom in opponent shooting. With George back in rhythm, Grimes providing a spark, and Maxey capable of exploding at any time, the Sixers have the balance and defensive structure to cover the number, especially if the Lakers remain shorthanded.
Lakers vs 76ers Over/Under Pick
- Under 235.5 (5 Units)
The Under 235.5 looks like the right angle in Lakers–Sixers because both teams have leaned on defense and slower stretches despite their offensive talent. Philadelphia just held Milwaukee to 101 points in a 116–101 win, showing how effective they can be at limiting perimeter looks with their 7th‑ranked three‑point defense (34.2%). The Lakers, meanwhile, just lost 126–105 to Boston, but they’ve averaged 116.5 points allowed (17th) while struggling to defend the arc, and their offense has been inconsistent when LeBron James and Luka Doncic aren’t fully healthy. With the Sixers ranking top‑10 in opponent shooting and the Lakers ranking 2nd in field‑goal percentage but only 27th in rebounding, this matchup sets up more as a grind than a shootout, making the Under 235.5 the sharper play.
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