Memphis Grizzlies vs San Antonio Spurs Prediction, Picks and Odds Movement for December 2, 2025
The Memphis Grizzlies and San Antonio Spurs meet on Monday night in a Western Conference matchup where both teams enter on equal rest after playing on Sunday. With the Spurs returning home and the Grizzlies playing their best basketball of the season, this contest sets up as a competitive handicap. Below you’ll find our full breakdown, including odds movement, matchup analysis, and expert NBA predictions.
Quick Picks and Prediction
- Spread Pick: Grizzlies +5.5
- Total Pick: Under 231.5
- Projected Final Score: Spurs 112, Grizzlies 108
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Odds and Line Movement
Opening Odds
| Team | Spread | Total |
|---|---|---|
| Memphis | +5.5 | 231.5 |
| San Antonio | -5.5 | 231.5 |
| # | Handicapper | Profit |
|---|---|---|
| 1 |  Rob Vincilleti | +1,763.00 |
| 2 |  Pro Sports Picks | +1,400.00 |
| 3 |  David Delano | +492.00 |
| 4 |  Arthur Reyes | +375.00 |
| 5 |  Michael Briggs | +355.00 |
Current Odds
| Team | Spread | Total |
|---|---|---|
| Memphis | +5 (-110) | 231.5 (-110) |
| San Antonio | -5 (-110) | 231.5 (-110) |
Line Movement - Spread
| Date | Time | Memphis | San Antonio | Public ($, #) |
|---|---|---|---|---|
| 12/01 | 11:36:32pm | 5 (-110) | -5 (-110) | |
| 12/01 | 08:08:21pm | 5.5 (-114) | -5.5 (-106) | |
| 12/01 | 08:02:02pm | 5.5 (-110) | -5.5 (-110) | |
| 12/01 | 07:31:11pm | 5.5 (-114) | -5.5 (-106) | |
| 12/01 | 07:14:41pm | 5.5 (-110) | -5.5 (-110) | |
| 12/01 | 07:12:02pm | 5.5 (-112) | -5.5 (-108) | |
| 12/01 | 07:03:37pm | 5.5 (-114) | -5.5 (-106) |
Line Movement - Total
| Date | Time | Over | Under | Public ($, #) |
|---|---|---|---|---|
| 12/01 | 09:52:48pm | 231.5 (-106) | 231.5 (-114) | |
| 12/01 | 08:55:23pm | 232 (-110) | 232 (-110) | |
| 12/01 | 07:03:37pm | 231.5 (-110) | 231.5 (-110) |
Memphis vs Spurs Key Matchups and Handicap
San Antonio won the first meeting two weeks ago 111-101 as a six-point home favorite, but that game was close throughout — the ten-point margin was the largest lead either team held. Memphis actually led entering the fourth quarter before the Spurs pulled away late.
San Antonio returns home after a split four-game road trip, earning wins over Portland and Denver while dropping games to Phoenix and Minnesota. Before that trip, the Spurs had won-and-covered three straight home games.
Memphis enters this contest in its best form of the season. The Grizzlies are 5-1 straight-up and against the spread in their last six games, with seven of their last nine staying under the total. The recent surge coincides with Zach Edey’s return to the lineup — and Ja Morant being out. Over the last eight games, the Grizzlies rank top-10 in net rating and top-5 in defensive rating, a massive contrast from their early-season struggles.
This matchup should once again be competitive. The previous game was played entirely within single digits, and with Memphis defending at an elite level during this stretch, the Grizzlies appear primed to keep this within the number again.
Betting Trends (MEM vs SA)
- MEM is 5-1 ATS in its last six games.
- Seven of MEM’s last nine games have gone under.
- SA has won-and-covered three straight home games prior to their road trip.
- The previous matchup stayed under the total.
Key Injuries and Notes (MEM vs SA)
- Memphis: No major injuries noted; playing best basketball of season.
- San Antonio: Key players expected available.
ATS and Total Picks
- ATS Pick: Grizzlies +5.5
- Total Pick: Under 231.5
Final Score Prediction
Spurs 112, Grizzlies 108
Stats to Know for Memphis vs San Antonio
- Memphis is top-5 in defensive rating over the last eight games.
- San Antonio is 3-0 ATS in its most recent home stretch.
- Seven of the last nine Memphis games have finished under.
- The previous meeting was within single digits for 47 minutes.
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