Minnesota Timberwolves vs. Portland Trail Blazers Prediction and Picks for Wednesday, October 22nd, 2025
Use Code SSWC The NBA season is underway, and the action continues on Wednesday night with a Western Conference clash between the Minnesota Timberwolves (0-0) and the Portland Trail Blazers (0-0). Below I’ll get you primed with the necessary betting information for this season-opening contest, before wrapping up with our Timberwolves vs. Trail Blazers prediction and picks. Tip-off is scheduled for 10:00 ET from the Moda Center in Portland, OR. Read on for free NBA picks on this game, and check out that link for other game breakdowns.
Timberwolves Trending Upward
The Western Conference is loaded with talent, and one of the teams that’s often overlooked is the Minnesota Timberwolves. Well, Coach Chris Finch and his TWolves have left their mark on the West the last two seasons, making conference finals runs in both years. Last season’s team went 49-33 and earned the sixth seed in the West. As for the new campaign, Minnesota is priced as a sizable -600 favorite to make the playoffs, while sitting at +1400 to win the title.
In terms of personnel, it’s a very similar cast for Minnesota this season. Of course, SG Anthony Edwards will lead things up top, and he’s coming off of a year where he averaged 27.6 points per game. Mike Conley (8.2 PPG, 4.5 APG) rounds out the backcourt, while Julius Randle (18.7 PPG, 7.1 RPG) and Rudy Gobert (12.0 PPG, 10.9 RPG) will look to handle things down low.
- The Timberwolves scored 113.5 points per game last season, which was the 16th-most in the NBA.
- They posted a field goal rate of 46.7% (16th), while cashing 37.4% of their triples (fourth).
- Minnesota’s defense was sixth in 2024-25, allowing 108.6 points per 100 possessions.
- In terms of their betting numbers, they went 58-39 SU and 48-48-1 ATS.
Trail Blazers Looking to Take Step Forward
Coach Chauncey Billups is back for his fifth season as the lead man of the Portland Trail Blazers, and he’s still trying to help guide this franchise back to the postseason. They’ve missed the playoffs all four years under his leadership. Last year’s team made a late push towards the play-in tournament, but ultimately fell short and finished 36-46. That was good enough for 12th in the Western Conference. The expectations aren’t very high for the Blazers entering the year, as they’re sitting at +390 underdogs to make the playoffs and +80000 to win the NBA championship.
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It’s a new-look Portland squad that will feature Jrue Holiday (11.1 PPG, 3.9 APG) running things in the backcourt. He comes over from Boston in a trade that sent Anfernee Simons back east. Damian Lillard also inked a deal with the Trail Blazers, but he’s sidelined for the entirety of the season with an Achilles injury. Shaedon Sharpe (18.5 PPG, 4.8 APG) is slotted in as the top shooting guard, while Donovan Clingan (6.5 PPG, 7.9 RPG) will play center. It’s worth noting that PG Scoot Henderson (hamstring) and C Robert Williams III (knee) are both out to start the season.
- Portland averaged 110.9 points per game last season, which was the 22nd-most in the Association.
- The Blazers ranked 25th in field goal rate (45.0%) and 26th in three-point shooting (34.2%).
- Defensively, they were 17th in efficiency, conceding 111.9 points per 100 possessions.
- From a sports betting perspective, Portland went 36-46 SU and 46-35-1 ATS.
Timberwolves vs. Trail Blazers Pick
Spread Pick for Timberwolves vs. Trail Blazers
- Minnesota Timberwolves -4.5 (-110) (5 units)
I’m riding with the Timberwolves in this game. Minnesota has proven to be a legit contender in the Western Conference for several seasons now, and they’re fully healthy heading into the season with stars in both the front and backcourts. With Anthony Edwards blossoming into a superstar and Julius Randle also contributing solid scoring, I am no longer worried about laying multiple possessions' worth of points with this Timberwolves team. They finished last season ranked fourth in three-point shooting (37.4%), while also ranking fourth in average margin of victory (+4.6).
With Anfernee Simmons out of the picture and Scoot Henderson out to start the campaign, I have to wonder how the Trail Blazers will find enough offense to keep this game close – especially against a top-10 Timberwolves defense.
Over/Under Pick for Timberwolves vs. Trail Blazers
- Under 221.5 (-110) (5 units)
I was initially thinking of making a play on the over in this game, but once again, I just have to wonder where Portland is going to get its points from. They’re tasked with taking on a Minnesota defense that took a slight step back last season, but still ranked sixth in defensive efficiency (108.6). On that note, Portland’s defense, which was a respectable 17th in efficiency (111.9), should get better with the addition of Jrue Holiday.
Finally, it’s worth noting that neither of these teams was in a huge rush to move the ball up the floor last season. Portland was 16th in pace, using 101.6 possessions per game. Minnesota was 23rd (99.8). I think we stay comfortably under this number, and I won’t be surprised if Portland is held to a sub-100 total. I’ll predict a 112-98 final score in favor of the visitors.
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