Philadelphia 76ers vs Indiana Pacers Picks and Prediction for Wednesday October 28 2026

By: Eddie Kline Published 10/28/2026, 12:30 AM ET

In the first game of a Wednesday night NBA on ESPN doubleheader, the Philadelphia 76ers will visit the Indiana Pacers. Tipoff is scheduled for October 28, 2026 at 7:00 pm EST and the setting will be Gainbridge Fieldhouse. The 76ers are a small 2.5 point road favorite and the total is set at 238.5. Be ready for all of this season's NBA action with our free NBA picks.

Philadelphia off to a solid start

The Philadelphia 76ers have advanced to the second round of the playoffs in six of the previous nine years and are equipped to take the next step. The 76ers (3-1) acquired All-Star G Jaylen Brown in a trade that sent Paul George to Boston and signed four-time MVP LeBron James to a free agent deal. On Monday, Philadelphia trailed by 12 points after one quarter and never recovered during a 106-93 home loss versus Detroit.ย 

All-Star G Tyrese Maxey led all scorers with 29 points (11-24 FG) to go along with five rebounds and four assists. LeBron James scored 18 points on 8-for-15 shooting and dished out five assists. Jaylen Brown added 16 points (5-20 FG), four rebounds, and four assists for the 76ers.ย 

Last season, Philadelphia ranked in the bottom five of the league in effective field goal percentage. The 76ers currently rank in the bottom three of the league in offensive efficiency (101.1) and are averaging 110 points per contest. During Mondayโ€™s loss, Philadelphia missed 20 of 27 three-point attempts and shot 40 percent overall.

Indiana playing at a slower pace

The Indiana Pacers appeared in the NBA Finals in 2025, but could never gain any traction last season with G Tyrese Haliburton sidelined by an Achilles injury. The Pacers (2-2) dropped 30 of 41 home games and finished with the second worst overall record in the NBA. On Monday, Indiana was outscored by 19 points during the second half of a 110-102 road loss against Milwaukee.ย 

Tyrese Haliburton led five Indiana players in double figures with 22 points (4-10 3PT) and nine assists. Talented F Pascal Siakam scored 20 points on 8-for-17 shooting to go along with 13 rebounds and six assists. Obi Toppin added 14 points and six rebounds in a reserve role for the Pacers.ย 

Last season, Indiana was tied with Dallas for 27th with a 108.5 offensive efficiency rating and averaged 112.4 points per game. The Pacers are playing at the 18th fastest tempo and are a middle of the pack offensive unit. During Mondayโ€™s loss, Indiana missed 35 of 48 three-point attempts and shot just 41 percent overall.ย 

Philadelphia 76ers vs Indiana Pacers Picks and Prediction

Pick: Indiana Pacers +2.5

Indiana C suffered a left ankle injury on Sunday and will not play in this game. Philadelphia G V.J. Edgecombe (abdomen) and C Joel Embiid (foot) are listed as day-to-day after missing Mondayโ€™s loss. The 76ers swept the four game series against the Pacers a season ago by an average margin of 16.8 points. Indiana lost their only home game and will be energized. Take the Pacers to win outright as a small underdog.

Pick: Over 238.5

Philadelphia is playing at the second fastest tempo in the league, but they have not been efficient on the offensive end of the floor. Indiana is playing without their big man Zubac and will want to push the tempo on their home court. The Pacers rank 19th in the league in defensive efficiency, so they will have to rely on getting buckets to win. Take the over.ย 

Final Score Prediction: Indiana Pacers win 126-119

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