Arizona Cardinals vs. Dallas Cowboys, Preview, Odds, Picks and Prediction, Monday, November 3, 2025

By: Craig Forde Published 11/01/2025, 10:36 PM ET
Dallas QB Dak Prescott
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Underachieving NFC teams meet up on Monday night, and we’re getting you ready with our Cardinals vs. Cowboys predictions. Arizona (2-5 SU, 4-3 ATS) is coming off a bye week but lost a 27-23 tilt to Green Bay in their most recent action. Dallas (3-4-1 SU, 4-4 ATS) was a 44-24 loser at Denver last week as +4 underdogs. This matchup kicks off at 8:15 EST from AT&T Stadium in Arlington. If you are struggling to pick winners, you've come to the right place. We have the strongest NFL Predictions. 

Cardinals left to dwell on slump

The Cardinals had a week off to let their five-game losing streak marinate. In their loss against the Packers two weeks ago, the offense had 330 yards and 23 first downs while the defense allowed 262 yards and 19 first downs.

Arizona sits 19th in the league in scoring offense, averaging 21.9 points per game. They are gaining 310.3 total yards a week, 21st overall, and their passing game is producing 199.9 of those yards each game. The team announced on Saturday that Jacoby Brissett will get a third straight start under center as Kyler Murray continues to deal with a foot injury. Brissett threw for 599 yards, 4 TDs and an interception in those two games. Last week he was sacked six times. The team’s most active receiver has been tight end Trey McBride, who is ninth in the league with 47 catches. The Cardinals’ rushing game averages 110.4 yards per game. Their top two rushers – Murray and Trey Benson – are both injured and out.

The Cardinals’ scoring defense ranks 13th in the NFL, allowing 22 points per game. Opponents are averaging a total of 335.7 yards per game against them. Versus the pass, Arizona is giving up 234.9 yards and against the rush, 100.9 yards per game. Arizona has only 4 interceptions and their 12 sacks are the sixth fewest in the league. Mack Wilson Sr. leads the team with 53 tackles, with 3 tackles for loss and an interception. Josh Sweat has a team-high 5 sacks as part of his 7 tackles for loss.

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Injury report (with most recent practice availability)

  • OL Kelvin Beachum (NIR) full
  • S Kitan Crawford (ankle) limited
  • RB Emari Demercado (ankle) limited
  • WR Zay Jones (knee) limited
  • QB Kyler Murray (foot) limited
  • DL Watler Nolen (calf) limited
  • LB BJ Ojulari (knee) limited
  • CB Will Johnson (groin) limited

Consistency continues to elude Cowboys

The Cowboys have yet to string anything together, with alternating wins and losses in the four games since their tie. They allowed a season-high 44 points in their loss at Denver, the defense giving up 426 yards and 25 first downs while the offense mustered 339 yards and 24 first downs.

Dallas boasts the second-best scoring offense in the game, averaging 30.8 points per game. They are gaining 384.1 total yards each week, also second-best in the league, and their passing game is providing a league-best 263.8 yards per game. Dak Prescott is coming off of his worst game of the week, in which he threw for 188 yards and 2 INTs. On the year, the Dallas QB ranks third in the league with 2,069 passing yards, is tied for third with 16 TDs, and has been intercepted five times. Georgie Pickens caught 43 of 63 passes thrown his way for 685 yards and 6 TDs. On the ground, they are getting 120.4 yards a week. Javonte Wiliams is third in the NFL with 633 rushing yards, with 8 TDs, the third most in the league.

The Dallas defense sits on the opposite end of where their offense is, second-worst with an average of 31.3 points per game against them. They are giving up 404.6 yards each game, the second-highest average against. Their 258.6 passing yards per game allowed is the worst mark in the league, and the 146 rushing yards yielded each week is the fourth worst. They’ve managed to record just 15 sacks and 4 interceptions. Kenneth Murray Jr. has a team-high 58 tackles with a sack and 4 tackles for loss. Donovan Wilson has 36 tackles to go with his team-best 2 interceptions and 3 pass deflections.

Injury report

  • P Byran Anger (illness) DNP
  • S Alijah Clark (ribs) DNP
  • LB Jack Sanborn (groin) DNP
  • S Donovan Wilson (elbow/shoulder) DNP
  • OT Ajani Cornelius (knee) limited
  • LB DeMarvion Overshown (knee) limited
  • CB Shavon Revel Jr. (knee) limited
  • OT Tyler Smith (knee) limited
  • S Juanyeh Thomas (migraine) limited
  • DT Perrion Winfrey (back) limited
  • C Cooper Beebe (ankle) full
  • NT Kenny Clark (elbow) full
  • DE Marshawn Kneeland (ankle) full
  • DB Reddy Steward (thigh) full

Cardinals vs. Cowboys Picks

Spread Pick for Cardinals vs. Cowboys

  • Cardinals +3 (5 units)

These two teams last met in 2023 when the Cardinals won by 12 points at home. Both teams are having their own different disasters this season. Prescott is having a career year and leading one of the best offenses in the league, but the Dallas defense has been in shambles since trading Micah Parsons before the start of the season. It doesn’t look as if they are getting any closer to solving issues on that end, either, after allowing 44 points against Denver. Arizona has not been able to get enough offense weekly, losing each of its five games by four points or less. The Cardinals are at least closer and with a week off, they’ve had a chance to rest up, as well as study their opponent a bit closer. You could certainly find a lot worse backups than Brissett, who has been pretty solid in his two games. He should be able to move the ball well against this Cowboys’ defense, and this should be another tight one for Arizona. The Cardinals are 7-2 SU and ATS in their last nine games versus Dallas.

Take Arizona getting the points.

Over/Under Pick for Cardinals vs. Cowboys

  • Over 53.5 (5 units)

These two teams hit the over when they last met, combining to score 44 points versus a 43.5-point total. This game does feature the second-best scoring offense in the league, and while the Cowboys have been inconsistent, they are averaging 41.3 points per game at home this season. They’ve also followed up all of their poor offensive performances by scoring big in the next game. Arizona’s defense is good, but not great, and their lack of pressure will give Prescott time to set up. On the offensive side, the Cardinals should be able to move the ball and get into scoring position against this Dallas defense. The added week of preparation will help them find the right scheme. The over is 10-5 between the two teams this season.

Take the over.

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