Baltimore Ravens vs. Buffalo Bills Picks and Prediction, Sunday, September 7, 2025
The NFL season is underway, and we close out Sunday’s week one slate with a marquee Sunday Night Football matchup between the Baltimore Ravens (0-0) and the Buffalo Bills (0-0). These franchises met twice last season, with the Ravens winning 35-10 in week four and the Bills getting revenge in a 27-25 divisional round contest. Kickoff is scheduled for 8:20 ET from Highmark Stadium in Orchard Park, NY. Don’t get penalized! Increase your bankroll with our NCAAF Betting Picks!
Ravens Primed for a Huge Season
Just how big are the expectations for Coach John Harbaugh and the Baltimore Ravens this season? They’re a sizable favorite to win the AFC North (-150), while also owning the shortest odds to win the Super Bowl (+700). The Ravens, who went 12-5 during the 2024 regular season, are coming off of a divisional round exit last year, where they lost to the Bills in a 27-25 affair. Coach Harbaugh returns both Todd Monken and Zach Orr as his offensive and defensive coordinators.
It will be a similar cast of personnel offensively for the Ravens, starting with two-time MVP QB Lamar Jackson under center. He threw for 4,172 yards on a 66.7% completion rate last year, adding 41 touchdowns to just four interceptions. He logged 915 yards and four touchdowns on the ground. RB Derrick Henry turned in a monster season, going for 1,921 yards and 16 touchdowns. Out wide, WRs Zay Flowers (1,059 yards, 4 TD) and Rashod Bateman (756 yards, 9 TD) rejoin the team, while veteran WR DeAndre Hopkins (610 yards, 5 TD) joins the organization.
- The Ravens were a juggernaut offensively last season, ranking third in scoring (30.1 PPG) and first in yards per contest (426.5).
- Defensively, Baltimore was eighth in both defensive scoring (21.2 PAPG) and yards allowed (319.2).
- Injury Report: CB Jaire Alexander (knee), G Daniel Faalele (illness), TE Isaiah Likely (foot), and FB Patrick Ricard (calf) all have unspecified statuses for Sunday, but the former two players were full participants at practice on Thursday.
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Bills Make an AFC Championship Run
Meanwhile, the Buffalo Bills are set to be a force in the AFC once again this season. They share a price of +700 with the Ravens to win the Super Bowl this season. Buffalo made it to the AFC Championship following a 13-4 regular-season campaign, but they were taken out by the AFC boogeyman, Patrick Mahomes and Kansas City (32-29) in the conference title game. Sean McDermott returns as the head coach, and he’ll have Joe Brady (offensive) and Bobby Babich (defensive) as the coordinators underneath him.
Reigning MVP Josh Allen will lead the offense in 2025, and he’s coming off of a season where he threw for 3,731 yards, 28 touchdowns, and six interceptions. He gained 531 yards and 12 touchdowns on the ground. Leading rusher James Cook (1,009 yards, 16 TD) will spearhead the rushing attack. Out wide, WRs Khalil Shakir (821 yards, 4 TD) and Keon Coleman (556 yards, 4 TD) will be Allen’s top targets.
- Buffalo was a top-tier offensive unit in 2024, ranking second in scoring (30.6 PPG) and 10th in yards per contest (361.2).
- The Bills were a mediocre defense last season, coming in at 12th in defensive scoring (21.6 PAPG) and 16th in yards allowed per week (340.7).
- Injury Report: K Tyler Bass (hip, groin) and DT DeWayne Carter (achilles) are out for Sunday, while CB Tre’Davious White (groin) is doubtful. WRs Khalil Shakir (ankle), Elijah Moore (personal), Keon Coleman (groin), and CB Christian Benford (groin) were all full participants at practice on Friday.
Ravens vs. Bills Pick
Spread Pick for Ravens vs. Bills
- Baltimore Ravens -1.0 (-105) (5 units)
I cannot pass up on the Ravens in a pick ‘em spot on Sunday Night Football. Sure, the quarterbacking rooms are a wash in this matchup between Lamar Jackson and Josh Allen. But after that, I struggle to find an area where the Bills have an advantage. That’s not necessarily an anti-Buffalo statement, but more of a pro-Baltimore take. The Ravens are the most complete team in the NFL heading into week 1, and they have a veteran head coach and fantastic offensive coordinator leading them.
The two biggest areas of concern for Buffalo are their secondary and their receiving group. That’s not ideal in today’s NFL, which has become a very passer-friendly league. The Bills, per PFF, own the 14th-best secondary and 19th-best receiving group entering the year. As long as the Ravens play a clean game and don’t find themselves in a massive turnover deficit, they should win this game.
Over/Under Pick for Ravens vs. Bills
- Over 50.5 (-110) (5 units)
While I’m not too high on Buffalo’s offensive weaponry, they always find a way to make it work. No one really pops out at you on their depth chart, but perhaps that just speaks to how poised of a player Josh Allen is. I think we’re in for a back-and-forth barnburner between these two explosive offenses, so I’m not going to overthink this one – give me the over.
These teams ranked second and third in scoring last year, each putting up at least 30.0 points per game. Only the Lions (33.1 PPG) were better. On the defensive side, interestingly, both units were outside of the top-10 in red zone percentage last season. Baltimore was 12th (54.0% opposing RZ TD%), while Buffalo was 16th (57.4%). With two high-converting offenses, I anticipate us receiving the necessary touchdowns to clear this threshold.
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