Buffalo Bills vs Las Vegas Raiders Picks and Prediction for Sunday October 18, 2026
The Buffalo Bills will travel to Las Vegas, Nevada, Sunday afternoon for an AFC matchup against the Las Vegas Raiders at Allegiant Stadium. Kickoff is scheduled for 4:25 PM, with national coverage available on CBS. Buffalo enters the week with a 4-1 overall record following their win Monday night against the Los Angeles Rams. The Bills will look to continue their offensive success against a Las Vegas team coming off a difficult performance. The Raiders enter the weekend with a 3-2 overall record following a disappointing 45-17 road loss against New England. The Bills are listed as a 6-point favorite, with the total set at 53.5 points. Buffalo is -285 on the moneyline, while Las Vegas comes in at +230. Stay in the news with our NFL Picks.
Buffalo looks to keep it rolling
Josh Allen is leading the Buffalo offense this season with 1249 yards and seven touchdowns on 91 completions, along with 239 yards and eight scores on 43 carries. James Cook III is leading Buffalo with 532 yards and five scores on 95 carries this season. Dalton Kincaid leads the team with 277 yards and one score on 16 catches. Khalil Shakir has added 256 yards on 18 catches, and Keon Coleman has chipped in heavily with 224 yards and two scores on 15 grabs.
Offensively, Buffalo was fantastic last week, scoring 37 points on 436 total yards. Defensively, Buffalo did have some issues, giving up 34 points on 454 yards but allowed only seven third-down conversions in the win. Josh Allen led the way for the Buffalo offense last week with 210 yards and one score on 12 completions, along with 121 yards and one touchdown on 10 carries. James Cook added 111 yards and two touchdowns on 25 carries. Khalil Shakir led the way with 80 yards on three receptions. Keon Coleman chipped in one catch for seven yards and a score.
Key Injury Report for Buffalo:
- Spencer Brown (Questionable ) - Back
- Landon Jackson (Inactive) - Knee
- Dee Alford (Inactive) - Ankle
- Joshua Palmer (Inactive) - Shoulder
- Ar'maj Reed-Adams (Inactive) - Coach's Decision
Raiders try to end skid
The Las Vegas Raiders defense was obliterated last week, giving up 45 points on 536 total yards. Offensively, Las Vegas did move the ball well, scoring 17 points on 306 total yards but turned the ball over one time and converted only five third downs in the loss. Kirk Cousins led the way for Las Vegas last week with 19 completions for 243 yards and one score. Ashton Jeanty was the top ball carrier with 27 yards on 10 carries and added 3 catches for 50 yards. Brock Bowers led all Las Vegas receivers with 110 yards and one touchdown on 8 receptions.
Kirk Cousins is leading the Las Vegas offense this season 1269 yards and 12 touchdowns on 110 completions. Ashton Jeanty is the top running back on the team with 291 yards on 88 carries. Mike Washington Jr. has added 25 carries for 125 yards and one score. Tight end Brock Bowers leads Las Vegas with 312 yards and three scores on 24 grabs. Tre Tucker has added 274 yards and one score on 19 catches, and Ashton Jeanty has chipped in 22 catches for 215 yards and two scores. Cody White has come up big for Las Vegas with 108 yards and three touchdowns on 7 catches.
Key Injury Report for Las Vegas:
- Tonka Hemingway (Questionable) - Concussion
- Jalen Nailor (Questionable) - Concussion
- Trey Zuhn III (Questionable) - Knee
- Patrick Johnson (Questionable)- Neck
- Dont'e Thornton Jr. (IR-R) - Hamstring
Buffalo Bills vs Las Vegas Raiders Picks and Prediction
Pick: Buffalo Bills -6
Buffalo is in a great spot to continue their winning streak Sunday afternoon against a Las Vegas team that struggled significantly in its previous outing. The Bills have one of the most dangerous offensive groups in football and should be able to create consistent scoring opportunities against the Raiders. Las Vegas has enough offensive talent to make things interesting but will need a much better defensive performance to keep pace with Buffalo. The Bills should be able to establish their offense early and force the Raiders into difficult situations throughout the game. Las Vegas will have the home crowd behind it, but Buffalo has the advantage in overall talent and offensive consistency. Take the Bills to get the job done on the road.
Pick: Over 53.5
Buffalo and Las Vegas have enough offensive firepower to produce a high-scoring matchup Sunday afternoon. The Bills have been effective moving the ball and should be able to create consistent scoring opportunities against a Raiders defense that struggled in its previous outing. Las Vegas has enough offensive weapons to contribute to the scoring and will look to establish an aggressive approach in front of its home crowd. Buffalo should be able to move the ball effectively throughout the game, while the Raiders could find themselves throwing more often if they fall behind early. Both teams have the potential to generate explosive plays, which could lead to several scoring opportunities. Expect Buffalo to establish the offensive pace and help push the combined score over the posted total.