Buffalo Bills vs Los Angeles Rams Picks and Prediction for Monday October 12 2026

All eyes will be on scenic SoFi Stadium, when Josh Allen and the Buffalo Bills square off against Matthew Stafford and the Los Angeles Rams. This will be the final game of the week five NFL schedule. Kickoff is scheduled for 8:15 pm EST on Monday October 12, 2026. The Rams are favored by three points and the total is set at 54.5. . Be sure to check out our free NFL picks for more NFL predictions throughout the season.

Buffalo Bills Flying High on Offense

The Buffalo Bills have reached the playoffs in seven consecutive seasons and are still in search of their first Super Bowl title in franchise history. The Bills (3-1) have scored at least 24 points in their first four games and hold a one-game lead over New England for the top spot in the AFC East Division. Last week, Buffalo gave up 405 yards of total offense during a 29-26 home loss versus the Patriots. 

James Cook III and Josh Allen scored rushing touchdowns in the first half to give Buffalo a 17-14 halftime advantage. Allen threw for 253 yards and connected with Keon Coleman for a 34-yard touchdown pass. Coleman finished with a game-high 116 receiving yards for the Bills, who possessed the ball for a little more than 26 minutes and committed a pair of turnovers. 

Buffalo ranks eighth in the NFL in total offense (386.3 ypg) and is the highest scoring team at a shade below 32 points per game. When the Bills enter the red zone, they are scoring touchdowns at a 69 percent clip. Buffalo must improve on the defensive side of the ball. The Bills are giving up 26.8 points per contest.

Los Angeles Loaded with Talent on Both Sides of the Ball

The Los Angeles Rams entered the season as the betting favorite to win Super Bowl LXI. The Rams (2-2) have stumbled out of the gate, but have won at least nine games in eight of the previous nine seasons. On Sunday, Los Angeles erased a ten point deficit in the final four minutes to escape with a 24-20 road victory against Philadelphia. 

Kyren Williams’ one-yard touchdown plunge capped a ten-play, 98 yard Los Angeles drive. Williams followed with a seven-yard touchdown with 70 seconds remaining to give the Rams the final margin. Veteran QB Matthew Stafford completed 32 of 51 passing attempts for 317 yards and was picked off twice. The Rams outgained the Eagles by a 415-172 margin.

Los Angeles ranks second behind Chicago in the NFL In total offense (417 ypg), but must clean up the turnovers. Through four games, the Rams have thrown six interceptions and lost a pair of fumbles. Despite playing without DE Myles Garrett, Los Angeles is the second best defensive unit and allows 20.8 points per contest.

Buffalo Bills vs Los Angeles Rams Picks and Prediction

Pick: Los Angeles Rams -3.5

Buffalo WR D.J. Moore is bothered by a shoulder injury and is listed as questionable for this game. With Josh Allen under center, the Bills are certainly good enough to win their first Super Bowl. However, the defense has been a bit leaky and the Rams will take full advantage. Los Angeles has the better defense and will cover at home.

Pick: Over 54.5

The roof will be closed, so conditions will be ideal for this game. In their first two victories, Buffalo was able to prevail despite surrendering 31 points each time. Los Angeles has an elite passing attack and will expose a Buffalo secondary that is allowing the sixth most passing yards. Take the over.

Final Score Prediction: Los Angeles Rams 34, Buffalo Bills 27