Buffalo Bills vs. New York Jets Picks and Prediction for Sunday, September 14, 2025
Week 2 of the NFL season is upon us, and we have an intriguing divisional contest getting us started on Sunday between the Buffalo Bills (1-0) and the New York Jets (0-1). We’ve got you covered with our Bills vs. Jets prediction. Kickoff is scheduled for 1:00 ET from MetLife Stadium in East Rutherford, NJ. Don’t get penalized! Increase your bankroll with our NFL Betting Picks!
Bills Win Barnburner vs. Ravens
Coach Sean McDermott and his Buffalo Bills haven’t been able to get over the hump and make a run to the Super Bowl just yet. However, the Bills are the betting favorites (+550) to hoist the Lombardi this season, which would be their first in franchise history. Under McDermott, who’s 87-45 as coach of the Bills, he has Joe Brady and Bobby Babich running the offense and defense, respectively.
In terms of personnel, it’s none other than reigning MVP winner Josh Allen leading the charge. Allen put on a heroic effort in the come-from-behind week 1 victory over the Ravens (41-40), throwing for 394 yards and two touchdowns, while adding 30 yards and two touchdowns on the ground. RB James Cook will spearhead the rushing attack again in 2025, and he logged 44 yards and a touchdown against Baltimore in week 1. Out wide, WRs Keon Coleman (112 yards, 1 TD) and Khalil Shakir (64 yards) will be Allen’s top targets.
- The Bills put up 41 points in week 1, and they’re coming off of a season where they were second in scoring (30.6 PPG) and 10th in yards per game (361.2).
- Defensively, they allowed 21.6 points per game (12th) and 340.7 yards per contest (16th) in 2024.
- Injury Report: As of this writing (Friday afternoon), DT Ed Oliver (ankle) is the only player confirmed out for Sunday. CB Taron Johnson (quad), OLB Shaq Thompson (hamstring/hand), CB Tre’Davious White (groin), and DB Jordan Hancock (shoulder) are all questionable.
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Jets Edged Out at Home
It’s a new era for the New York Jets, as they’ve made replacements in key areas with Coach Aaron Glenn taking over the team and QB Justin Fields going under center. While the Jets dropped their home opener to the Steelers (34-32) in week 1, they did at least see their revamped offense light it up for 32 points. Fields threw for 218 yards and a touchdown, while adding 48 yards and two touchdowns on the ground. Breece Hall logged 107 yards on 19 totes (5.6 YPC).
Overall, the expectations still aren’t too high this season for New York. They sit at +2800 to win the AFC East, while owning an updated win total of just 5.5 (-155/+130).
- New York’s offense looked excellent last week, putting up 32 points. That’s a vast improvement from last season, when the Jets were 24th in scoring (19.9 PPG).
- On the defensive side, they were decent in 2024, ranking 19th in points against (23.8) and fifth in yards allowed per contest (313.8).
- Injury Report: The latest Jets injury report has no specific designations, but we do know that RB Kene Nwangwu (hamstring), DL Jay Tufele (illness), and WR Josh Reynolds (hamstring) didn’t practice on Thursday.
Bills vs. Jets Pick
Spread Pick for Bills vs. Jets
- Buffalo Bills -6.0 (-110) (5 units)
The Bills mounted that legendary comeback on Sunday Night Football, and they’re now entering a relatively easy stretch with games against the Jets, Dolphins, Saints, and Patriots. Even though Buffalo is on the road and without DT Ed Oliver (ankle), I still think they manage to win this game by 7+ points.
The disparity between the two offenses is just too much. Although Justin Fields looked serviceable in week 1, I do not trust him to keep a game close if he’s trailing and forced to pass. Even last weekend, the signal caller only threw for 218 yards. The Bills are coming off of a season where they were second in scoring (30.6 PPG), and considering they just put up 41 points on a top-tier Ravens defense, it’s safe to say they’re in midseason form. I’ll lock in Buffalo while they’re inside of touchdown favorites.
Over/Under Pick for Bills vs. Jets
- Over 46.5 (-110) (5 units)
If you read my articles often, then you’ll occasionally see me write, “‘Team X’ has a chance to clear this total by themselves.” I don’t anticipate Buffalo dropping a 50-burger on New York this weekend, but would anyone be surprised if they put up another 35-to-40 points on Sunday? The offense will be taking on a secondary that PFF ranked 11th entering the season, so Allen & Co. should be able to put up points against this mid-tier group.
These two dual-threat quarterbacks are also going to make life tough on the opposing defenses. In addition to Justin Fields’ running capabilities, the Jets are going to have a decent edge in the trenches. New York’s offensive line was ninth in the preseason PFF rankings, and they’ll be taking on the Ed Oliver-less front seven of Buffalo. I don’t think the Jets go nuclear offensively, but if they come within a couple of points of their team total (19.5), then that should be enough to help up get this final score over the total.
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