Carolina Panthers vs. Green Bay Packers, Preview, Odds, Prediction and Picks, Monday, Nov. 24, 2025
Use Code SSWC Two NFC postseason hopefuls get on the Monday night stage and we’re getting you ready for prime-time action with our Panthers vs. 49ers predictions. Carolina (6-5 SU, 7-4 ATS) picked off a 30-27 win at Atlanta last Sunday as +3.5 underdogs. San Francisco (7-4 SU, 6-5 ATS) won at Arizona last weekend, 41-22, as -3.5 favorites. Kick off from Levi’s Stadium is scheduled for 8:15 EST and make sure to increase your bankroll with all of our NFL Picks!
Panthers claw way into the picture
A 1-3 SU team to start the season, the Panthers have been surging up the charts. After going 5-2 SU over their last seven games, they find themselves in ninth place overall in the NFC playoff picture and just a half game out of first place in the NFC South.
Carolina had their highest offensive output in five games last weekend. They are averaging just 18.8 points per game this season, 28th in the NFL. They rank 22nd in total offense, averaging 314.3 yards per game, with 187.2 passing yards and 127.1 rushing yards per game. Bryce Young had a career game and set a franchise record with 448 passing yards in the win over Atlanta. The third-year QB has completed 62.7% of his passes for 1,962 yards, 14 TDs, and 7 INTs. Tetairoa McMillan is tied for 15th in the league with 54 catches and his 748 receiving yards rank sixth overall. Rico Dowdle is fourth in the NFL with 833 rushing yards on 169 carries.
The Panthers’ scoring defense ranks 13th in the NFL, giving up an average of 22.6 points per game. They are 15th in total defense, yielding 325.9 yards each time out, on average. Against the pass, they give up 212.8 yards, and versus the run, 113.1 rushing yards per game. They have recorded 16 sacks and 7 interceptions. Christian Rozenboom leads the team and is tied for seventh in the league with 91 tackles, including 5 tackles for loss. Nic Scourton and Derrick Brown each have a team-high 3 sacks.
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Injury report for Panthers
- LB Christian Rozeboom (hip/hamstring) DNP
- LB Trevin Wallace (shoulder) DNP
- DT Tershawn Wharton (knee) full
- QB Bryce Young (ankle) full
- WR Tetairoa McMillan (ankle) full
- WR Xavier Legette (hip) full
- S Lathan Ransom (hand) full
- CB Akayleb Evans (ankle) limited
- C Cade Mays (ankle) full
Ebb and flow plaguing 49ers
Since their three-game win streak to open the season, the 49ers have alternated a loss with a win in every week. They are in third place in the NFC West and seventh place in the conference playoff race.
The San Francisco offense put up a season-high 41 points in their most recent effort. They rank 15th in scoring, averaging 23.7 points each game. Their 349.9 total yards per game ranks 10th overall, with 254.5 passing yards, second best in the game. The Niners also gain 94.8 rushing yards per game. Brock Purdy returned last week and threw for 200 yards and 3 TDs. In three games, he’s connected on 67.7% of his passes for 786 yards, 7 TDs, 4 INTs and he’s been sacked just three times. Christian McCaffrey leads the team in both rushing (707) and receiving yards (732). He has rushed for 6 TDs, caught 5 TDs and his 74 receptions are second most in the NFL.
On defense, the 49ers are allowing 22.9 points per game, 15th in the league. In the yardage department, opponents are averaging 352.9 per game against them. Against the pass, San Francisco is giving up 249.1 yards and versus the rush, 103.8 per game. They are tied for second-fewest interceptions with 3 and they’ve recorded a league-low 12 sacks. Dee Winters leads the club and ranks 24th in the league with 77 tackles, six of them for a loss. Bryce Huff also has 6 tackles for loss to go with a team-high 4 sacks.
Injury report for 49ers
- DE Robert Beal Jr. (concussion) DNP
- LB Tatum Bethune (ankle) DNP
- LB Luke Gifford (hip/neck) limited
- RB Christian McCaffrey (NIR-rest) full
- WR Ricky Pearsall (knee) full
- K Eddy Pineiro (hamstring) DNP
- QB Brock Purdy (toe) full
- LB Curtis Robinson (elbow) full
- OT Trent Williams (NIR-rest) full
- LB Dee Winters (knee) full
Panthers vs. 49ers Picks
Spread Pick for Panthers vs. 49ers
- Carolina -7 (5 units)
The last meeting between these two came back in 2022, a game the Niners won by 22 points a -6 favorite on the road. San Francisco’s offense looked great in Purdy’s return last week and will surely look to ride that momentum into this game. That effort came versus an Arizona defense that ranks in the bottom third of the league. Carolina will present a much tougher test for Purdy and company. The Panthers’ offense also had a big offensive effort last weekend, but they have a better chance of keeping that going with the Niners' lack of pressure up front. Giving Young time in the pocket could be trouble. Carolina started the season 0-3 SU in road games but won their last three away from home. San Francisco is just 2-2 SU at home this season. The Panthers are rolling, Young is coming off of the best game of his career and with the Niners winning last week, that puts them in line for a loss here, based on their current trend.
Take the Panthers getting the points.
Over/Under Pick for Panthers vs. 49ers
- Under 49.5 (5 units)
Each team averages under 24 points on the offensive end, but both are coming off of 30+ point performances. Carolina’s offense has been struggling mightily to score at times this season. Prior to their 30-point effort last weekend they scored 16 points or less in three straight games. The Niners have had their issues as well and are more than likely not going for 40 again. Their major offensive pieces always seem a hit away from missing a series of downs, or worse. While I do see some of that offensive momentum for both teams creeping into this game, it’s going to be a lot tighter in the long run.
Take the under.
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