Cincinnati Bengals vs Buffalo Bills Prediction and Picks - December 7, 2025
Sunday afternoon National Football League action, and we have a Cincinnati Bengals vs Buffalo Bills prediction locked and loaded for you. The Bengals enter this game off a stunning 32-14 road win over the Ravens and they are now 4-8 on the year. Boffal comes in off a solid 26-7 road win over Pittsburgh and they have now gone 8-4 on the year. Read on to see our Bengals vs Bills prediction.
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Bengals Stun The Ravens On The Road
Cincinnati’s most recent game was a 32–14 win over the Baltimore Ravens on November 27, where Joe Burrow returned to form with 261 passing yards and two touchdowns, while Ja’Marr Chase hauled in seven catches for 110 yards. It was a much‑needed victory that snapped a four‑game losing streak and reminded everyone what this offense looks like when Burrow is healthy and in rhythm.
The Bengals’ offense has been uneven this season, ranking 22nd in total yards (313.3 per game) and dead last in rushing (88.5 yards per game). Burrow’s presence elevates the passing attack, which sits 11th at 224.8 yards per game, but turnovers have been costly — Cincinnati has committed 18 giveaways (27th). Chase remains the focal point with 971 receiving yards, while Chase Brown has added balance with 704 rushing yards despite the team’s overall struggles on the ground. Tee Higgins, who has been in concussion protocol, returned to practice this week and is listed as questionable, a potentially huge boost if he’s cleared.
Defensively, Cincinnati has been one of the league’s weakest units, ranking 32nd in total defense (410.0 yards allowed) and giving up a league‑worst 31.2 points per game. They’ve struggled against both the pass (256.8 yards allowed, 32nd) and the run (153.3 yards allowed, 31st). Injuries have compounded the issues: DE Trey Hendrickson (hip, out), LB Shaka Heyward (fibula, limited), and CB Cam Taylor‑Britt (foot, IR) headline the list. Safety Jordan Battle leads the team with 92 tackles, but the lack of consistent pass rush and coverage breakdowns have left the Bengals vulnerable. Against Buffalo’s balanced attack, Cincinnati’s defense will need to find ways to generate turnovers to stay competitive.
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Bills Dominate The Steelers
Buffalo’s most recent game was a 26–7 win over the Pittsburgh Steelers on November 30, where Josh Allen threw for 123 yards and a touchdown while James Cook gashed Pittsburgh for 144 rushing yards on 32 carries. The Bills dominated time of possession and leaned on their ground game to control the pace, moving to 8–4 and solidifying their playoff positioning.
Offensively, Buffalo has been one of the league’s most productive units, ranking 2nd in total yards (381.0 per game) and 5th in points scored (28.1 per game). They lead the NFL in rushing at 155.7 yards per game, with Cook already over 1,200 yards and eight touchdowns. Allen has thrown for 2,832 yards with 19 touchdowns, while also adding 11 rushing scores, making him one of the most dangerous dual‑threat quarterbacks in football. Khalil Shakir leads the receiving corps with 569 yards, and rookie Keon Coleman has emerged as a red‑zone target. The Bills have committed 17 turnovers (23rd), but their ability to sustain drives and finish in the red zone has kept them among the league’s elite offenses.
Defensively, Buffalo ranks 8th in total defense (304.5 yards allowed) and is the league’s best against the pass (163.2 yards allowed per game). They’ve been more vulnerable against the run (141.3 yards allowed, 30th), but overall they allow just 21.6 points per game (13th). Injuries are significant: DE Joey Bosa (hamstring/wrist, out), LB Terrel Bernard (elbow, out), and WR Joshua Palmer (knee/ankle, doubtful) are all sidelined, while OT Dion Dawkins (concussion, cleared) and OT Spencer Brown (shoulder, questionable) remain key storylines. Tight end Dalton Kincaid is also questionable with hamstring/knee issues, and his absence would limit Buffalo’s passing attack over the middle. Even with those concerns, the Bills’ defensive front and secondary give them a clear edge against Cincinnati’s struggling offensive line.
Cincinnati Bengals vs Buffalo Bills Pick
Bengals vs Bills Spread Pick
- Buffalo -6 (4 Units)
Buffalo -6 feels like the right side because the Bills are coming off a convincing 26–7 win over Pittsburgh, where Josh Allen managed the game efficiently and James Cook dominated on the ground with 144 rushing yards. That performance highlighted Buffalo’s balance, as they lead the league in rushing (155.7 yards per game) while still ranking top‑10 in passing. The offense averages 28.1 points per game (5th), and even with some injuries at receiver and tight end, Allen’s dual‑threat ability keeps defenses guessing. Against a Cincinnati team that has committed 18 turnovers (27th) and struggles to protect Burrow, Buffalo’s defensive front should be able to dictate the pace.
The other edge comes from Buffalo’s defense, which ranks 8th in total yards allowed (304.5) and is the NFL’s best against the pass (163.2 yards per game). That’s a nightmare matchup for a Bengals team that leans heavily on Joe Burrow and Ja’Marr Chase, especially with Tee Higgins still questionable. Cincinnati’s defense, meanwhile, has been a liability, giving up a league‑worst 31.2 points per game and ranking dead last in both passing and rushing yards allowed. Even if Burrow finds some success, the Bengals’ inability to stop anyone consistently makes it hard to see them keeping pace. With Buffalo’s ground game rolling and their defense built to shut down Cincinnati’s passing attack, laying the six points looks justified.
Bengals vs Bills Over/Under Pick
- Under 53 (4 Units)
The Under 53 makes a lot of sense in Bengals–Bills, especially with weather looming as a factor. Buffalo just leaned heavily on James Cook in their 26–7 win over Pittsburgh, piling up 144 rushing yards while Josh Allen threw for only 123, and that blueprint fits perfectly in a cold, windy December setting. Cincinnati, meanwhile, has been inconsistent offensively and still ranks 30th in rushing at just 88.5 yards per game, which makes sustaining drives tougher if conditions limit Burrow’s deep shots to Ja’Marr Chase. Add in the fact that Buffalo’s defense is elite against the pass (163.2 yards allowed, 1st in the NFL) and Cincinnati’s defense, while porous overall, has at least shown the ability to force opponents into longer possessions, and you’ve got the recipe for a slower, grind‑it‑out game. With both teams likely leaning on the run and weather tightening things further, the Under looks like the sharper angle.
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