Detroit Lions vs Arizona Cardinals Picks and Predictions for Sunday, October 11, 2026

The Detroit Lions visit the Arizona Cardinals on Sunday at State Farm Stadium in Glendale, with kickoff scheduled for 4:25 PM ET and coverage on Fox. Detroit are third in the NFC North with a 2-2 record after losing 32-26 to Carolina. Arizona are fourth in the NFC West at 1-3 following a 36-24 defeat against the New York Giants. The Lions have split their first four games, while the Cardinals have lost three straight. Detroit are 5.5-point road favorites, with the total set at 54.5. Let's break down the matchup with our free NFL picks.

Detroit Lions Trying to Improve Their Road Record

Detroit has alternated wins and losses through four games, defeating New Orleans 31-30 in overtime and the New York Jets 31-24. The Lions lost 41-31 at Buffalo before their latest defeat against Carolina. Detroit has scored at least 26 points in every game but remains winless in two road appearances. Jared Goff has completed 67.7% of his passes for 303.5 yards per game, nine touchdowns and no interceptions. Amon-Ra St. Brown leads Detroit with 31 receptions, 303 receiving yards and five touchdowns.

The Lions average 303.5 passing yards and 102.0 rushing yards per game, with 14 offensive touchdowns. Jahmyr Gibbs leads the rushing attack with 353 yards and five rushing touchdowns, adding 187 receiving yards and two more scores. Detroit averages 29.8 points while allowing 31.8 per game. The defense has recorded 15 sacks and two interceptions, with Aidan Hutchinson contributing 3.5 sacks. Jack Campbell leads the team with 32 tackles. Detroit's offense has remained productive, but the defense has allowed at least 24 points in every game.

Injuries: Tyleik Williams (questionable), DJ Wonnum (questionable), Ben Bartch (questionable), Brian Branch (questionable), Cade Mays (out).

Arizona Cardinals Searching for Their Second Victory

Arizona opened the season with a 26-14 victory over the Los Angeles Chargers before losing three consecutive games. The Cardinals fell 31-7 against Seattle, 36-30 at San Francisco and 36-24 against the New York Giants. Arizona has allowed at least 31 points in each defeat. Jacoby Brissett has completed 67.8% of his passes for 204.5 yards per game, six touchdowns and four interceptions. Michael Wilson leads the receiving group with 25 catches and 258 yards, while Trey McBride has recorded 33 receptions, 242 yards and two touchdowns.

The Cardinals average 204.5 passing yards and 100.5 rushing yards per game, with nine offensive touchdowns. Jeremiyah Love leads Arizona with 223 rushing yards and one rushing touchdown, while Tyler Allgeier has added 112 yards and one score. Arizona averages 21.8 points while allowing 29.3 per game. The defense has recorded eight sacks and three interceptions, with Budda Baker contributing 25 tackles and one interception. Jack Gibbens leads Arizona with 32 tackles. The Cardinals have struggled to limit opposing offenses, particularly during their current losing streak.

Injuries: Walter Nolen III (questionable), Karson Sharar (questionable), Jeremiyah Love (questionable), Dadrion Taylor-Demerson (questionable), Andrew Wingard (questionable).

Key to the Game

Detroit's passing attack against Arizona's struggling defense is the central matchup. Goff averages 303.5 passing yards per game and has thrown nine touchdowns without an interception. Arizona have allowed 103 points across their last three games, including consecutive 36-point performances by San Francisco and the Giants. However, Detroit has also struggled defensively, conceding 31.8 points per contest. Brissett's four interceptions and Arizona's limited rushing production create additional concerns. Both defenses have allowed substantial scoring, placing greater importance on turnovers and red-zone execution.

Detroit Lions vs Arizona Cardinals Game Pick

• Detroit Lions -5.5 (-110)

Detroit are the pick against the 5.5-point spread after averaging 29.8 points per game through four contests. Goff has thrown nine touchdowns without an interception, while Gibbs has scored seven total touchdowns. Arizona has lost three consecutive games and allowed at least 31 points in each defeat. The Cardinals also average just 21.8 points, compared with Detroit's 29.8. Although the Lions have struggled defensively, their stronger passing attack and Arizona's recent defensive problems make a victory by at least six points a reasonable expectation this Sunday.

Detroit Lions vs Arizona Cardinals Over/Under Pick

• over 54.5 (-115)

Over 54.5 points is the pick, with Detroit averaging 29.8 points per game and allowing 31.8. Arizona has scored 21.8 points per contest while conceding 29.3, including at least 31 in three consecutive defeats. The Lions have scored 26 or more points in every game, while three of their four contests have produced at least 55 combined points. Arizona's last two games also finished above that mark. With both defenses struggling to limit scoring, another high-scoring matchup is likely at State Farm Stadium on Sunday.