Detroit Lions vs. Baltimore Ravens Picks and Prediction - Monday, September 22, 2025
We have you covered on the final NFL game of the week with our Lions vs. Ravens predictions for Monday night. Detroit (1-1 SU, 1-1 ATS) had an offensive explosion last week, beating Chicago, 52-21, as -6.5 favorites at home. Baltimore (1-1 SU, 1-1 ATS) also won big in week 2, taking down Cleveland, 41-17, as -13.5 favorites at home. Kickoff from M&T Bank Stadium is scheduled for 8:15 EST and stay on top of all of the league action with our top free NFL Picks!
Lions offense gets team on track
After taking the L in their season opener against Green Bay, the Lions roared back with a 52-point performance, matching last season’s best offensive output and it came against the former offensive coordinator who was behind it. They scored at least 10 points in all four quarters, and the offense went for 511 total yards and 25 first downs. The defense gave up just seven second half points and allowed 339 total yards.
Following last week’s effort, the Detroit offense is averaging 378.5 total yards and 32.5 points per game. The passing attack has averaged 267 yards per game. Jared Goff was excellent last week, going 23-28 for 335 yards and 5 TDs. This season he’s connected on 80.6% of his passes for 559 yards, 6 TDs and one interception. Amon-Ra St. Brown has caught 13 of the 17 passes he’s been targeted on for 160 yards and 3 TDs. The Lions’ rushing game is averaging 111.5 yards per game. Jahmyr Gibbs has averaged 5.4 yards per carry and leads the team with 113 rushing yards and a touchdown. He also has 13 catches for 41 yards and two first downs.
On the defensive side, the Lions are giving up 24 points and 302.5 total yards per game. Opposition rushing attacks are averaging 106 yards and 4.1 yards per carry against them. Versus the pass, Detroit is allowing 196.5 yards per game. They’ve been able to sack the opposing QB four times and pick off one pass. Safety Brian Branch has been all over the place, picking up 11 tackles, three for a loss, a sack, a pass deflection and a forced fumble. Linebacker Jack Campbell leads the squad with 18 tackles, nine of them solo. He was limited in practice this week due to an ankle injury.
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Injury report
- DE Marcus Davenport (chest) out
- LB Jack Campbell (ankle) questionable
- S Kerby Joseph (knee) questionable
- CB D.J. Reed (knee) questionable
- T Taylor Decker (shoulder) questionable
Ravens still a bit off balance
The Ravens are just two points shy of being an undefeated team through two games as they fared quite while in making up for their week 1 loss against Buffalo. The defense held up well, holding Cleveland to 323 yards while forcing two turnovers, including a fumble return for a touchdown. The offense struggled a bit, gaining only 242 total yards and just 45 via the rush.
The defense, which was run over a bit by Buffalo in the season opener, is allowing 29 points and 409.5 total yards per game. They’ve had the second-worst passing defense, allowing 298.5 yards per game despite opponents averaging just 6.5 yards per pass against them. They have struggled to put pressure on, recording just three sacks and an interception. Against the run, they are giving up 111.5 yards per game and 4.2 yards per carry. Linebacker Roquan Smith leads the team and is fourth in the NFL with 25 tackles, including three for a loss. Defensive tackle Nnamdi Madubuike, who leads the team with two sacks, has been ruled out of this game with a neck injury.
The Ravens lead the league with an average of 40.5 points per game, but their offense is averaging only 33 total yards per game, 11th overall. Despite last week’s efforts, the run game is averaging 141.5 yards per game. On 29 carries, Derrick Henry picked up 192 yards and two touchdowns but also fumbled twice. Their passing attack ranks 22nd in the league, averaging 195.5 yards per game. Lamar Jackson has completed 68.8% of his passes for 434 yards and 6 TDs. He’s also rushed for 83 yards and a touchdown. Jackson has targeted Zay Flowers 20 times, connecting 14 times for 218 yards and a TD. The line has allowed five sacks.
Injury report
- TE Isaiah Likely (foot) questionable
- DT Nnamdi Madubuike (neck) out
- FB Patrick Ricard (calf) out
- MLB Kyle Van Noy (hamstring) out
- CB Nate Wiggins (groin) questionable
Lions vs. Ravens Picks
Spread Pick for Lions vs. Ravens
- Detroit +5 (5 units)
These two last met in 2023, a game Baltimore won by 32 points as -3 favorites at home. These two teams have had pretty similar starts to their seasons, dropping their season opener before putting up big numbers to capture their first wins in week 2. Both sides faced bad defenses last week, which allowed them to put up those numbers, so things should be a little tougher this week. The Ravens defense, which has already lacked pressure, will be without their top sacker, Madubuike. That should allow Goff a few more seconds here and there to find his targets. The Lions' two-headed rushing attack of Gibbs and David Montgomery is also going to keep the Baltimore defense on its heels, and I foresee the visitors having plenty of opportunities to put points on the board. Jackson hasn’t been all that accurate throwing the ball for Baltimore and Henry got absolutely stuffed by Chicago’s defense last week. I do expect both players to have better games here, and they should be able to stay in stride, keeping this game close down to the wire.
Take the Lions getting the points.
Over/Under Pick for Lions vs. Ravens
- Over 53 (4 units)
Last week, these two teams had a combined 93 points between them, though noted above, versus some lesser defenses. While both of these defenses should offer up a bit more resistance, they also both have some holes early on. Both are also banged up on the defensive front coming in. Even if we chip away some points from the totals of both teams’ efforts last week, we still have a good chunk of scoring. There are a ton of weapons on both sides. The Lions with Goff, Gibbs and Brown, among others, and Jackson and Henry might be the best QB-RB combo going. With the spotlight on, I think both teams get offensive in this matchup. The over is 3-2 in the last five games between the teams.
Take the over.
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