Green Bay Packers vs. Arizona Cardinals Prediction and Picks for Sunday, October 19th, 2025
Use Code SSWC The NFL action continues on Sunday afternoon, and this should be an intriguing NFC showdown in the desert, as the Green Bay Packers (3-1-1) square off against the Arizona Cardinals (2-4) out west. We’ve got you covered with our Packers vs. Cardinals prediction. Kickoff is scheduled for 4:25 ET from State Farm Stadium in Glendale, AZ. Don’t get penalized! Increase your bankroll with our NFL Betting Picks!
Packers Take Care of Bengals, Sit at 3-1-1
The expectations are lofty for Coach Matt LaFleur and his Green Bay Packers this season. The team lived up to the hype in Week 1, hammering the Lions 27-13 in Green Bay. They botched a game in Cleveland and lost 13-10, and also drew even in a 40-40 draw against the Cowboys. The Pack seem to be finding their groove once again, as it bounced back with a solid 27-18 victory over the Bengals last weekend. At 3-1-1, they’re atop the NFC North standings. Green Bay is a -105 favorite to win the division. If you’re looking to take a long-term stake in the Packers, they’re as high as +800 to win the Super Bowl. As for the game-by-game betting numbers, they’ve gone 2-3 ATS and 3-2 to the under.
QB Jordan Love is the man under center in Green Bay, and he’s putting together a quality season. The signal caller has thrown for 1,259 yards on a 70.1% completion rate, adding nine touchdowns and two interceptions. TE Tucker Kraft (268 yards, 3 TD) and WR Romeo Doubs (234 yards, 4 TD) are the top targets in the passing attack. RB Josh Jacobs has spearheaded the ground game, gaining 359 yards and six touchdowns on 98 totes (3.7 YPC).
- Offensively, the Packers are scoring 26.2 points per game (eighth), while averaging 359.6 yards per week (ninth).
- Defensively, they are 10th in the NFL this year, conceding 20.4 points per game. They’re allowing 280.2 yards per contest, which is fifth.
- Injury Report: The Packers have a lengthy injury report, but the only players that did not practice (DNP) on Thursday were K Brandon McManus (quadricep), DL Lukas Van Ness (foot), and DL Devonte Wyatt (knee).
Cardinals Drop Fourth Straight Game
Meanwhile, the Arizona Cardinals were expected to take a step forward in 2025, but they’ve fallen flat on their faces so far. Following a 2-0 start, the Cardinals have dropped four straight games to the 49ers (16-15), Seahawks (23-20), Titans (22-21), and Colts (31-27), most recently. Their 2-4 start puts them in the cellar of the NFC West, but the good news is that the rest of the teams are all 4-2, so the gap isn’t insurmountable. The sports betting market disagrees, pricing Arizona at +6000 to win the NFC West. They’re also +1000 just to make the postseason.
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QB Kyler Murray (foot) missed the last game, and he has been limited in practice this week. If he is unable to go on Sunday, it’ll be Jacoby Brissett getting the start once again. He looked decent in the 31-27 loss to the Colts, throwing for 320 yards and a 2/1 TD/INT ratio on a 27-for-44 (61.4%) completion rate. WR Marvin Harrison Jr. (338 yards, 2 TD) is also dealing with a concussion injury. TE Trey McBride is the lead option in the passing game, and he has 37 receptions for 347 yards and two touchdowns. The running back room is also an infirmary, and RB Michael Carter (86 yards, 1 TD) is listed atop the depth chart heading into the week.
- Arizona’s offense has been stagnant this season, ranking 20th in scoring (21.7 PPG), while putting up 307.0 yards per game (22nd).
- On the defensive side, the Cardinals are 14th this season, allowing 21.2 points per game. In terms of yardage, they’re 24th, conceding 348.0 yards per contest.
- Injury Report: Arizona’s DNPs on Thursday include: RB Emari Demercado (ankle), WR Zay Jones (knee), and SAF Kitan Crawford (ankle). Both QB Kyler Murray (foot) and WR Marvin Harrison Jr. (concussion) were limited.
Packers vs. Cardinals Pick
Spread Pick for Packers vs. Cardinals
- Green Bay Packers -6.5 (-110) (5 units)
If I were to play the Cardinals at home in this spot, I’d need at least the full 7.0 points. I think this game ending 24-17 or 20-13 is a likely outcome. So, with that being said, I am going to ride with the Packers in this game while the line is inside of a touchdown.
For me, this pick really boils down to two factors. First, it’s the injuries that the Cardinals are dealing with. QB Kyler Murray has a foot injury (which is severe since he’s most dangerous on the move), WR Marvin Harrison is working through a concussion, and the running backs room has been absolutely plagued by injuries this season. This offense won’t be at full strength, and they'll be tasked with trying to keep pace with a very efficient Green Bay offense. The Packers don’t really run up the score on teams, but they do rank first in third-down offense (52.3%) and sixth in red-zone touchdown percentage (71.4%). All things considered, I like the Packers to win this game by 7 or 10 points and to cover.
Over/Under Pick for Packers vs. Cardinals
- Under 45.0 (-110) (5 units)
As I mentioned above, Green Bay doesn’t really run up the score on teams. It seems like they have the talent to do so, but they play a pretty conservative brand of football. They’re using 30.9 seconds per play, which is the fourth-slowest mark in the league. Arizona is the 10th-slowest in the same category (30.3). The Packers have only had 46+ combined points in one of their five games this year.
Green Bay has gone 4-2 to the under in its last six games. The under is 4-1 in the last five meetings between the teams, as well as 6-1 in the last seven meetings in Arizona. With neither offense really firing on all cylinders, I think this final score finishes under the number.
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