Green Bay Packers vs. Detroit Lions Prediction and Picks – Thursday, November 27, 2025
The Green Bay Packers will visit the Detroit Lions for the first game of this year's Thanksgiving slate, and we'll preview the lines and odds in our Packers vs. Lions prediction. These teams played their first matchup of the season in Week 1–the Packers dominated the matchup, 27-13, securing their first win over the Lions in Green Bay since 2021. Kickoff is set for 1:00 PM ET on Thursday, November 27.
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Can Packers sweep Lions, pull ahead in NFC North race?
At 7-3-1, the Green Bay Packers enter Week 13 in the thick of a tightly-contested race for the NFC North. They're half a game behind the 8-3 Chicago Bears and half a game ahead of the 7-4 Lions. A win on Thursday would give the Packers a significant advantage in the standings–they'll have swept the Lions for the first time since 2020, and they'll have a 3-0 record in the division after last Sunday's 23-6 win over the Vikings.
The Packers weren't bad against the Vikings, but they didn't win the game nearly as much as the Vikings lost it. Green Bay punted on the first drive of the second half, but retook possession at the five-yard line after returner Myles Price failed to down the ball. Emanuel Wilson took two handoffs for the five yards needed to reach the endzone, putting Green Bay up 17-6. The Vikings' next drive ended in a punt after gaining only two yards; their next two drives each lost yards before ending in punts, while their last two drives of the game both ended in interceptions. The Packers' last five drives yielded a modest 116 total yards and two field goals–enough to win the day, or at least not lose it.
Offensively, the Packers rank 13th in total yards (338.9), 14th in passing yards (222.5), 15th in rushing yards (116.5), and 13th in points (23.9) per game. Defensively, they rank fourth in yards (278.7), fifth in passing yards (182.3), sixth in rushing yards (96.5), and fifth in points (18.4) allowed per game. The defense totaled seven tackles for loss, 10 quarterback hits, five sacks, and two interceptions in the win over the Vikings. Wilson led the offense, carrying the ball 28 times for 107 yards and both of the team's touchdowns.
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Key Injury Report for Packers:
- CB Kaisean Nixon (neck) is questionable.
- CB Nate Hobbs (knee) is questionable.
- DE Karlo Brooks (ankle) is questionable. DNP on Tuesday.
- RB Josh Jacobs (wknee) was limited in practice on Tuesday. Is questionbale.
- WR Matthew Golden (wrist) was limited. Is questionable.
Lions 7-4 after narrowly escaping with win against Giants
The Detroit Lions have alternated wins and losses over their past six games, falling to 7-4 after a 4-1 start to the season and dropping to third place in the NFC North. They're 2.5-point favorites at home against the Packers on Thursday, but they're half a game behind the Packers in the standings, are only 1-2 against divisional opponents this season, and already lost their season opener in Green Bay. The Lions' alternating win-loss pattern would have them losing on Thursday afternoon–if they do, it'll be a massive blow to their chances to win the NFC North.
The Lions spent Week 12 hosting the New York Giants, who took them to overtime before allowing the Lions to escape with a 34-27 win. Jahmyr Gibbs did most of the work–he took 15 carries for 219 yards and two touchdowns, including the deciding score in overtime, while also racking up 45 yards and a touchdown on 11 catches. Amon-Ra St. Brown was similarly involved after a quiet Week 11, hauling in nine of 13 targets for 149 yards and a touchdown. Little else went well for the Lions–Jared Goff completed 8 of 13 passes for 85 yards when targeting anybody else on the offense, failing to connect with Jameson Williams on any of three targets. The defense gave up 517 yards, 25 first downs, and eight third-down conversions to the Giants in Jameis Winston's second start as the team's quarterback and Mike Kafka's second game as interim head coach.
Offensively, the Lions rank fourth in total yards (378.5), eighth in passing yards (238.6), third in rushing yards (139.8), and second in points (29.6) per game. Defensively, they're 10th in total yards (312.3), 15th in passing yards (210.5), 11th in rushing yards (101.7), and 12th in points (22.1) allowed per game.
Key Injury Report for Lions:
- OT Penei Sewell (shoulder) and OT Taylor Decker are questionable.
- C Graham Glasgow (knee) is questionable.
- CB Terrion Arnold (concussion) is questionable.
Packers vs. Lions Team Pick
Spread Pick and Prediction for Packers vs. Lions
- Packers +2.5 (-102) (4 Units)
The Packers contained Gibbs when they hosted the Lions in Week 1, holding him to 19 yards on nine rushes and 31 yards on ten catches. Their defense might not look nearly as strong on Thursday as they did in September–or when they faced the Vikings days ago–but they're the unit in this matchup that deserves the most confidence ahead of kickoff. None of the Packers' four November opponents thus far have scored more than 20 points. Even if the Packers' offense looks conservative and uninspired on Thursday, it may very well be enough for them to win.
Over/Under Pick for Packers vs. Lions
- Under 49.0 (-110) (4 Units)
None of the Packers' last four games have totaled 49 points–their 27-20 win over the Giants two weeks ago is the highest-scoring game of the bunch. The Lions' offense has looked lethal at times this season, but they've spent several weeks either living on explosive plays from Jahmyr Gibbs or dying from a lack of them. They scored 13 points when the Packers bottled Gibbs up in Week 1, and they scored nine points when Gibbs only ran for 39 yards (and led the team through the air) against the Eagles two weeks ago.
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