Indianapolis Colts vs Jacksonville Jaguars Picks and Prediction for Sunday November 1, 2026
The Indianapolis Colts will travel to Jacksonville, Florida, Sunday afternoon for an AFC South matchup against the Jacksonville Jaguars inside EverBank Stadium. The game is scheduled to begin at 1 PM ET, with CBS coverage. Indianapolis comes into Sunday at 2-5 overall, looking to turn things around after a disappointing start to the season. Jacksonville returns home at 4-2 overall following its bye week. Jacksonville is a 9.5-point home favorite and a -500 on the money line. Indianapolis is a +380, and the total is set at 46.5 points. Keep up with our NFL Picks.
Colts desperate to end losing streak
Daniel Jones is leading the Indianapolis offense this season with 1,398 yards and four scores on 143 completions, along with 68 yards and one touchdown on 21 carries. Jonathan Taylor is the top ball carrier on the team with 587 yards and eight touchdowns on 140 carries, and Seth McGowan has added 134 yards on 32 carries this season. Josh Downs is the top receiver on the team with 307 yards on 26 catches. Keenan Allen has added 29 catches for 258 yards and one score, and Tyler Warren has chipped in 30 grabs for 213 yards and two touchdowns.
Offensively, Indianapolis struggled a week ago, scoring just 10 points, including none in the second half, on 218 total yards after turning the ball over one time in the game. Defensively, Indianapolis was outmatched, giving up 275 yards and 16 points. Daniel Jones led the way for the Indianapolis offense, completing 13 passes for 108 yards in the game. Jonathan Taylor led the way out of the backfield with 95 yards and one score on 18 carries. Keenan Allen was the top target against Minnesota with 31 yards on three catches.
Key Injury Report for Indianapolis:
- Bryce Boettcher (Questionable) - Groin
- Anthony Gould (Out) - Concussion
- Drew Ogletree (Questionable) - Knee
- Justin Walley (Out) - Knee
- Cam Taylor-Britt (IR) – Groin
Jacksonville tries to get back rolling
Trevor Lawrence is leading the Jacksonville offense this season with 1,480 yards and 14 scores on 120 completions. Bhayshul Tuten is the top ball carrier on the team with 388 yards and two scores on 94 carries, and Chris Rodriguez has added 39 carries for 168 yards and two scores. Parker Washington is the top receiver on the team with 416 yards and four touchdowns on 26 receptions. Jakobi Meyers has added 20 catches for 285 yards and two scores.
Defensively, Jacksonville was outmatched before their bye week, giving up 34 points on 426 total yards. Offensively, Jacksonville did move the ball well, scoring 31 points on 412 yards, but turned the ball over one time in the loss. Trevor Lawrence led the way for the Jacksonville offense, completing 24 passes for 306 yards and four scores. Chris Rodriguez was the top ball carrier with 55 yards on 11 carries. Jakobi Meyers led the team with 83 yards on five receptions. Bhayshul Tuten added 39 yards on 12 carries and 48 yards and two touchdowns on four grabs.
Key Injury Report for Jacksonville :
- Antonio Johnson (Out) - Ankle
- Jakobi Meyers (Questionable) - Hamstring
- Anton Harrison (IR) - Knee
- Caleb Ransaw (IR) - Knee
- NJ Green II (IR) - Elbow
Indianapolis vs Jacksonville Picks and Prediction
Pick: Jacksonville Jaguars -9.5
Jacksonville is the better team coming into this matchup, and the Jaguars should have enough offensive firepower to handle Indianapolis at home. Trevor Lawrence has played well this season, and Jacksonville should be able to move the football against a Colts team that has struggled to find consistency. Indianapolis will rely heavily on Jonathan Taylor, but Jacksonville should be able to limit the running game and force the Colts to throw the football. Look for the Jaguars to take control early and pull away in the second half for a comfortable home victory.
Total Pick: Under 46.5
Indianapolis could have problems consistently moving the football against Jacksonville, especially if the Jaguars can contain Jonathan Taylor. Jacksonville should be able to put points on the board, but the Jaguars may lean on their running game and control possession if they build an early lead. That would limit the number of opportunities for Indianapolis to respond. Expect Jacksonville to dictate the pace and keep the Colts from contributing enough offensively to push this game over the total.