Indianapolis Colts vs Minnesota Vikings Picks and Prediction for Sunday October 25, 2026
The Indianapolis Colts will travel to Minneapolis, Minnesota, Sunday afternoon for a matchup against the undefeated Minnesota Vikings at U.S. Bank Stadium. Kickoff is scheduled for 1:00 PM Eastern, and coverage will be available on CBS. Indianapolis comes into Sunday with a 2-4 record following a disappointing 26-20 loss against Tennessee in its last outing. Minnesota is a perfect 5-0 this season and returns from its bye week following a 23-13 victory over New Orleans. The Vikings enter this matchup as 6.5-point home favorites at -290 on the moneyline. Indianapolis is +235 on the moneyline, and the total is set at 41.5 points. Stay in the action with our NFL Picks.
Colts Desperate to Right the Ship
Daniel Jones is leading the Indianapolis offense this season with 1,290 passing yards and four touchdowns on 130 completions. Jonathan Taylor is the top ball carrier on the team with 492 yards and seven scores on 122 carries. Josh Downs leads all Indianapolis receivers with 289 yards on 24 catches. Keenan Allen has 227 yards and one touchdown on 26 catches, while Tyler Warren has added 30 receptions for 213 yards and two scores.
The Indianapolis offense scored 20 points on 399 total yards last week but converted just seven third downs and turned the ball over three times in the loss. Defensively, Indianapolis allowed only 186 total yards, but Tennessee scored 26 points, including 20 in the fourth quarter, resulting in the Colts' loss. Daniel Jones completed 22 passes for 269 yards and one touchdown to lead Indianapolis but threw two interceptions as well. Jonathan Taylor led the way on the ground with 94 yards and one touchdown on 21 carries. Keenan Allen was the top target in the Indianapolis offense with 82 yards on eight receptions.
Key Injury Report for Indianapolis:
- Bryce Boettcher (Questionable) – Groin
- Sauce Gardner (Out) – Calf
- Tyler Warren (Out) – Groin
- Anthony Gould (Out) – Concussion
- CJ Allen (Questionable) – Ankle
Minnesota Looks to Keep It Rolling
The Minnesota Vikings offense is averaging 21.8 points per game this season through five games played. Defensively, Minnesota is allowing just 12.8 points per game. Kyler Murray is leading Minnesota this season with 662 passing yards and two touchdowns on 69 completions, along with 93 rushing yards on 20 carries. Aaron Jones Sr. is the top ball carrier on the team with 410 yards and two scores on 97 carries. Justin Jefferson leads all Minnesota receivers with 258 yards and three touchdowns on 19 catches. T.J. Hockenson has added 202 yards and one score on 23 catches, while Jordan Addison has chipped in 11 receptions for 163 yards and one touchdown.
The Minnesota defense held strong last week, giving up just 13 points on 142 total yards while forcing three turnovers. Offensively, Minnesota scored 23 points, including 17 in the second half, on 364 total yards. Kyler Murray led Minnesota last week, completing 24 passes for 229 yards and one touchdown while adding 51 rushing yards on ten carries. Aaron Jones Sr. led all ball carriers with 113 yards and one touchdown on 25 carries. Justin Jefferson posted a team-high 79 yards and one touchdown on six catches.
Key Injury Report for Minnesota:
- Jordan Mason (IR-R) – Thumb
- Donovan Jackson (IR) – Knee
- Josh Oliver (IR) – Biceps
- Nick Samac (IR) – Knee
- Tyler Batty (IR) – Knee
Indianapolis Colts vs Minnesota Vikings Picks and Prediction
Pick: Minnesota Vikings -6.5
Minnesota returns home Sunday afternoon looking to remain undefeated against an Indianapolis team that has struggled to find consistency on both sides of the football. The Vikings have been extremely effective defensively this season, using an aggressive pass rush to disrupt opposing quarterbacks and force mistakes. Indianapolis quarterback Daniel Jones has struggled with turnovers, and Minnesota's ability to create pressure should make it difficult for the Colts to establish a consistent passing attack. Jonathan Taylor will need to produce on the ground to keep Indianapolis competitive, but the Vikings have the defensive personnel to limit his opportunities and force Jones into difficult situations. Minnesota also has the advantage of coming off a bye week, giving the Vikings additional preparation time against a Colts team that has dropped consecutive games. Look for Minnesota to control the game defensively and cover the spread at home.
Pick: Under 41.5
Indianapolis and Minnesota could find themselves in a defensive battle Sunday afternoon, especially with the Vikings allowing fewer than 13 points per game through their first five outings. Minnesota has been extremely difficult to move the football against, and its ability to pressure opposing quarterbacks should limit the number of sustained scoring drives Indianapolis can put together. The Colts have struggled offensively during their recent losing streak, and facing one of the league's toughest defenses on the road will not make things any easier. Minnesota has enough offensive talent to move the football, but the Vikings have also been comfortable winning games without putting up huge scoring totals. Expect Minnesota to establish its running game, control possession, and put its defense in favorable situations throughout the afternoon. With Indianapolis likely struggling to generate consistent offensive production, the under looks like the stronger play.